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Irwin McLean
Irwin McLean
Emeritus Professor of Genetic Medicine, University of Dundee
Verified email at dundee.ac.uk - Homepage
Title
Cited by
Cited by
Year
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
CNA Palmer, AD Irvine, A Terron-Kwiatkowski, Y Zhao, H Liao, SP Lee, ...
Nature genetics 38 (4), 441-446, 2006
36042006
Filaggrin mutations associated with skin and allergic diseases
AD Irvine, WHI McLean, DYM Leung
New England Journal of Medicine 365 (14), 1315-1327, 2011
14062011
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
FJD Smith, AD Irvine, A Terron-Kwiatkowski, A Sandilands, LE Campbell, ...
Nature genetics 38 (3), 337-342, 2006
13022006
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
LC Tsoi, SL Spain, J Knight, E Ellinghaus, PE Stuart, F Capon, J Ding, ...
Nature genetics 44 (12), 1341-1348, 2012
10452012
Filaggrin in the frontline: role in skin barrier function and disease
A Sandilands, C Sutherland, AD Irvine, WHI McLean
Journal of cell science 122 (9), 1285-1294, 2009
10242009
Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
A Strange, F Capon, CCA Spencer, J Knight, ME Weale, MH Allen, ...
Nature genetics 42 (11), 985, 2010
10142010
Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
EL Simpson, JR Chalmers, JM Hanifin, KS Thomas, MJ Cork, ...
Journal of Allergy and Clinical Immunology 134 (4), 818-823, 2014
8612014
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
A Sandilands, A Terron-Kwiatkowski, PR Hull, GM O'Regan, TH Clayton, ...
Nature genetics 39 (5), 650-654, 2007
7902007
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
S Weidinger, T Illig, H Baurecht, AD Irvine, E Rodriguez, A Diaz-Lacava, ...
Journal of Allergy and Clinical Immunology 118 (1), 214-219, 2006
7562006
Filaggrin in atopic dermatitis
GM O'Regan, A Sandilands, WHI McLean, AD Irvine
Journal of Allergy and Clinical Immunology 122 (4), 689-693, 2008
6702008
One remarkable molecule: filaggrin
SJ Brown, WHI McLean
Journal of Investigative Dermatology 132 (3), 751-762, 2012
6672012
Intermediate filament proteins and their associated diseases
MB Omary, PA Coulombe, WHI McLean
New England Journal of Medicine 351 (20), 2087-2100, 2004
5852004
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
JS Ried, J Li, XB Zuo, XD Zheng, XY Yin, LD Sun, MA McAleer, ...
Nature genetics 47 (12), 1449-1456, 2015
5832015
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming
PG Fallon, T Sasaki, A Sandilands, LE Campbell, SP Saunders, ...
Nature genetics 41 (5), 602-608, 2009
5502009
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
SJ Brown, Y Asai, HJ Cordell, LE Campbell, Y Zhao, H Liao, K Northstone, ...
Journal of allergy and clinical immunology 127 (3), 661-667, 2011
5342011
Filaggrin mutations, atopic eczema, hay fever, and asthma in children
S Weidinger, M O'Sullivan, T Illig, H Baurecht, M Depner, E Rodriguez, ...
Journal of Allergy and Clinical Immunology 121 (5), 1203-1209. e1, 2008
5142008
Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype–genotype correlation
AD Irvine, WHI McLean
British Journal of Dermatology 140 (5), 815-828, 1999
4661999
Plectin deficiency results in muscular dystrophy with epidermolysis bullosa
FJD Smith, RAJ Eady, IM Leigh, JR McMillan, EL Rugg, DP Kelsell, ...
Nature genetics 13 (4), 450-457, 1996
4581996
Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood
JNWN Barker, CNA Palmer, Y Zhao, H Liao, PR Hull, SP Lee, MH Allen, ...
Journal of Investigative Dermatology 127 (3), 564-567, 2007
4362007
The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study
J Henderson, K Northstone, SP Lee, H Liao, Y Zhao, M Pembrey, ...
Journal of Allergy and Clinical Immunology 121 (4), 872-877. e9, 2008
4292008
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