Richard T Eastman
Richard T Eastman
Novartis Institutes for BioMedical Research- Global Health
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Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19
RT Eastman, JS Roth, KR Brimacombe, A Simeonov, M Shen, S Patnaik, ...
ACS central Science 6 (5), 672-683, 2020
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
RT Eastman, DA Fidock
Nature Reviews Microbiology 7 (12), 864-874, 2009
Drug-resistant malaria: molecular mechanisms and implications for public health
I Petersen, R Eastman, M Lanzer
FEBS letters 585 (11), 1551-1562, 2011
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
SH Adjalley, GL Johnston, T Li, RT Eastman, EH Ekland, AG Eappen, ...
Proceedings of the National Academy of Sciences 108 (47), E1214-E1223, 2011
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics
MH Gelb, WC Van Voorhis, FS Buckner, K Yokoyama, R Eastman, ...
Molecular and biochemical parasitology 126 (2), 155-163, 2003
Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-Pressured Plasmodium falciparum Parasites
RT Eastman, NV Dharia, EA Winzeler, DA Fidock
Antimicrobial agents and chemotherapy 55 (8), 3908-3916, 2011
Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation
RT Eastman, FS Buckner, K Yokoyama, MH Gelb, WC Van Voorhis
Journal of lipid research 47 (2), 233-240, 2006
Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate
AM Lisewski, JP Quiros, CL Ng, AK Adikesavan, K Miura, N Putluri, ...
Cell 158 (4), 916-928, 2014
Recent highlights in antimalarial drug resistance and chemotherapy research
DA Fidock, RT Eastman, SA Ward, SR Meshnick
Trends in parasitology 24 (12), 537-544, 2008
Deep learning identifies synergistic drug combinations for treating COVID-19
W Jin, JM Stokes, RT Eastman, Z Itkin, AV Zakharov, JJ Collins, ...
Proceedings of the National Academy of Sciences 118 (39), e2105070118, 2021
High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations
BT Mott, RT Eastman, R Guha, KS Sherlach, A Siriwardana, P Shinn, ...
Scientific reports 5 (1), 13891, 2015
A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation
KK Ojo, RT Eastman, RSR Vidadala, Z Zhang, KL Rivas, R Choi, JD Lutz, ...
The Journal of infectious diseases 209 (2), 275-284, 2014
Trypanosoma cruzi Inactivation in Human Platelet Concentrates and Plasma by a Psoralen (Amotosalen HCl) and Long-Wavelength UV
WC Van Voorhis, LK Barrett, RT Eastman, R Alfonso, K Dupuis
Antimicrobial agents and chemotherapy 47 (2), 475-479, 2003
The Candida albicans Lanosterol 14-α-Demethylase (ERG11) Gene Promoter Is Maximally Induced after Prolonged Growth with Antifungal Drugs
JL Song, JB Harry, RT Eastman, BG Oliver, TC White
Antimicrobial agents and chemotherapy 48 (4), 1136-1144, 2004
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum
RT Eastman, J White, O Hucke, K Bauer, K Yokoyama, L Nallan, ...
Journal of Biological Chemistry 280 (14), 13554-13559, 2005
Drug repurposing screen for compounds inhibiting the cytopathic effect of SARS-CoV-2
CZ Chen, P Shinn, Z Itkin, RT Eastman, R Bostwick, L Rasmussen, ...
Frontiers in Pharmacology 11, 592737, 2021
Synergistic and antagonistic drug combinations against SARS-CoV-2
T Bobrowski, L Chen, RT Eastman, Z Itkin, P Shinn, CZ Chen, H Guo, ...
Molecular Therapy 29 (2), 873-885, 2021
Targeting ACE2–RBD interaction as a platform for COVID-19 therapeutics: Development and drug-repurposing screen of an AlphaLISA proximity assay
QM Hanson, KM Wilson, M Shen, Z Itkin, RT Eastman, P Shinn, MD Hall
ACS Pharmacology & Translational Science 3 (6), 1352-1360, 2020
An OpenData portal to share COVID-19 drug repurposing data in real time
KR Brimacombe, T Zhao, RT Eastman, X Hu, K Wang, M Backus, ...
BioRxiv, 2020
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents
J Ohkanda, FS Buckner, JW Lockman, K Yokoyama, D Carrico, ...
Journal of medicinal chemistry 47 (2), 432-445, 2004
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