Christian Heinis
Christian Heinis
Professor, EPFL
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An engineered protein tag for multiprotein labeling in living cells
A Gautier, A Juillerat, C Heinis, IR Corrêa, M Kindermann, F Beaufils, ...
Chemistry & biology 15 (2), 128-136, 2008
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
C Heinis, T Rutherford, S Freund, G Winter
Nature chemical biology 5 (7), 502-507, 2009
Cyclic peptide therapeutics: past, present and future
A Zorzi, K Deyle, C Heinis
Current opinion in chemical biology 38, 24-29, 2017
Bicyclic peptide inhibitor reveals large contact interface with a protease target
A Angelini, L Cendron, S Chen, J Touati, G Winter, G Zanotti, C Heinis
ACS chemical biology 7 (5), 817-821, 2012
Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling
T Gronemeyer, C Chidley, A Juillerat, C Heinis, K Johnsson
Protein Engineering, Design and Selection 19 (7), 309-316, 2006
Strategies to prolong the plasma residence time of peptide drugs
L Pollaro, C Heinis
MedChemComm 1 (5), 319-324, 2010
Phage selection of cyclic peptides for application in research and drug development
K Deyle, XD Kong, C Heinis
Accounts of chemical research 50 (8), 1866-1874, 2017
Cyclization of peptides with two chemical bridges affords large scaffold diversities
SS Kale, C Villequey, XD Kong, A Zorzi, K Deyle, C Heinis
Nature chemistry 10 (7), 715-723, 2018
Peptide ligands stabilized by small molecules
S Chen, D Bertoldo, A Angelini, F Pojer, C Heinis
Angewandte Chemie International Edition 53 (6), 1602-1606, 2014
Encoded libraries of chemically modified peptides
C Heinis, G Winter
Current opinion in chemical biology 26, 89-98, 2015
Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides
S Chen, J Morales‐Sanfrutos, A Angelini, B Cutting, C Heinis
ChemBioChem 13 (7), 1032-1038, 2012
Tools and rules for macrocycles
C Heinis
Nature chemical biology 10 (9), 696-698, 2014
Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
A Zorzi, SJ Middendorp, J Wilbs, K Deyle, C Heinis
Nature communications 8 (1), 16092, 2017
Engineering Substrate Specificity of O6‐Alkylguanine‐DNA Alkyltransferase for Specific Protein Labeling in Living Cells
A Juillerat, C Heinis, I Sielaff, J Barnikow, H Jaccard, B Kunz, A Terskikh, ...
ChemBioChem 6 (7), 1263-1269, 2005
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides
S Chen, R Gopalakrishnan, T Schaer, F Marger, R Hovius, D Bertrand, ...
Nature chemistry 6 (11), 1009-1016, 2014
Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries
S Chen, I Rentero Rebollo, SA Buth, J Morales-Sanfrutos, J Touati, ...
Journal of the American Chemical Society 135 (17), 6562-6569, 2013
Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides
I Rentero Rebollo, M Sabisz, V Baeriswyl, C Heinis
Nucleic acids research 42 (22), e169-e169, 2014
Measuring in vivo protein half-life
K Bojkowska, FS de Sio, I Barde, S Offner, S Verp, C Heinis, K Johnsson, ...
Chemistry & biology 18 (6), 805-815, 2011
Phage selection of photoswitchable peptide ligands
S Bellotto, S Chen, I Rentero Rebollo, HA Wegner, C Heinis
Journal of the American Chemical Society 136 (16), 5880-5883, 2014
Boosting the sensitivity of ligand–protein screening by NMR of long-lived states
N Salvi, R Buratto, A Bornet, S Ulzega, I Rentero Rebollo, A Angelini, ...
Journal of the American Chemical Society 134 (27), 11076-11079, 2012
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