| Insights into protein–protein binding by binding free energy calculation and free energy decomposition for the Ras–Raf and Ras–RalGDS complexes H Gohlke, C Kiel, DA Case Journal of molecular biology 330 (4), 891-913, 2003 | 1279 | 2003 |
| Network pharmacology: curing causal mechanisms instead of treating symptoms C Nogales, ZM Mamdouh, M List, C Kiel, AI Casas, HHHW Schmidt Trends in pharmacological sciences, 2021 | 366 | 2021 |
| Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network G Markson, C Kiel, R Hyde, S Brown, P Charalabous, A Bremm, J Semple, ... Genome research 19 (10), 1905-1911, 2009 | 210 | 2009 |
| Recognizing and defining true Ras binding domains I: biochemical analysis S Wohlgemuth, C Kiel, A Krämer, L Serrano, F Wittinghofer, C Herrmann Journal of molecular biology 348 (3), 741-758, 2005 | 210 | 2005 |
| Engineering signal transduction pathways C Kiel, E Yus, L Serrano Cell 140 (1), 33-47, 2010 | 157 | 2010 |
| Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations C Kiel, S Wohlgemuth, F Rousseau, J Schymkowitz, J Ferkinghoff-Borg, ... Journal of molecular biology 348 (3), 759-775, 2005 | 132 | 2005 |
| Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex C Kiel, T Selzer, Y Shaul, G Schreiber, C Herrmann Proceedings of the National Academy of Sciences 101 (25), 9223-9228, 2004 | 131 | 2004 |
| Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain G Piccoli, F Onofri, MD Cirnaru, CJO Kaiser, P Jagtap, A Kastenmüller, ... Molecular and cellular biology 34 (12), 2147-2161, 2014 | 121 | 2014 |
| Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculations EP Rakoczy, C Kiel, R McKeone, F Stricher, L Serrano Journal of molecular biology 405 (2), 584-606, 2011 | 112 | 2011 |
| A detailed thermodynamic analysis of ras/effector complex interfaces C Kiel, L Serrano, C Herrmann Journal of molecular biology 340 (5), 1039-1058, 2004 | 109 | 2004 |
| Analyzing protein interaction networks using structural information C Kiel, P Beltrao, L Serrano Annu. Rev. Biochem. 77, 415-441, 2008 | 104 | 2008 |
| The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopes C Kiel, L Serrano Journal of molecular biology 355 (4), 821-844, 2006 | 101 | 2006 |
| Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP MR Ahmadian, C Kiel, P Stege, K Scheffzek Journal of molecular biology 329 (4), 699-710, 2003 | 81 | 2003 |
| Cell type–specific importance of Ras–c-Raf complex association rate constants for MAPK signaling C Kiel, L Serrano Science signaling 2 (81), ra38-ra38, 2009 | 78 | 2009 |
| Structure‐energy‐based predictions and network modelling of RAS opathy and cancer missense mutations C Kiel, L Serrano Molecular systems biology 10 (5), 727, 2014 | 75 | 2014 |
| Structures in systems biology P Beltrao, C Kiel, L Serrano Current opinion in structural biology 17 (3), 378-384, 2007 | 73 | 2007 |
| Integration of protein abundance and structure data reveals competition in the ErbB signaling network C Kiel, E Verschueren, JS Yang, L Serrano Science signaling 6 (306), ra109-ra109, 2013 | 57 | 2013 |
| Improved binding of Raf to Ras· GDP is correlated with biological activity C Kiel, D Filchtinski, M Spoerner, G Schreiber, HR Kalbitzer, C Herrmann Journal of Biological Chemistry 284 (46), 31893-31902, 2009 | 53 | 2009 |
| The Activation of RalGDS Can Be Achieved Independently of Its Ras Binding Domain: IMPLICATIONS OF AN ACTIVATION MECHANISM IN Ras EFFECTOR SPECIFICITY AND SIGNAL DISTRIBUTION* 210 T Linnemann, C Kiel, P Herter, C Herrmann Journal of Biological Chemistry 277 (10), 7831-7837, 2002 | 52 | 2002 |
| Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D SA Kennedy, MA Jarboui, S Srihari, C Raso, K Bryan, L Dernayka, ... Nature communications 11 (1), 1-14, 2020 | 51 | 2020 |
