| Tacrine–trolox hybrids: a novel class of centrally active, nonhepatotoxic multi-target-directed ligands exerting anticholinesterase and antioxidant activities with low in vivo … E Nepovimova, J Korabecny, R Dolezal, K Babkova, A Ondrejicek, D Jun, ... Journal of Medicinal Chemistry 58 (22), 8985-9003, 2015 | 153 | 2015 |
| SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides L Gorecki, J Korabecny, K Musilek, D Malinak, E Nepovimova, R Dolezal, ... Archives of toxicology 90, 2831-2859, 2016 | 104 | 2016 |
| 7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies J Korabecny, R Dolezal, P Cabelova, A Horova, E Hruba, J Ricny, ... European journal of medicinal chemistry 82, 426-438, 2014 | 94 | 2014 |
| Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease K Chalupova, J Korabecny, M Bartolini, B Monti, D Lamba, R Caliandro, ... European journal of medicinal chemistry 168, 491-514, 2019 | 92 | 2019 |
| Multitarget tacrine hybrids with neuroprotective properties to confront Alzheimer’s disease K Spilovska, J Korabecny, E Nepovimova, R Dolezal, E Mezeiova, ... Current Topics in Medicinal Chemistry 17 (9), 1006-1026, 2017 | 89 | 2017 |
| From pyridinium-based to centrally active acetylcholinesterase reactivators J Korabecny, O Soukup, R Dolezal, K Spilovska, E Nepovimova, M Andrs, ... Mini Reviews in Medicinal Chemistry 14 (3), 215-221, 2014 | 68 | 2014 |
| The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease V Hepnarova, J Korabecny, L Matouskova, P Jost, L Muckova, ... European Journal of Medicinal Chemistry 150, 292-306, 2018 | 66 | 2018 |
| New antituberculotics originated from salicylanilides with promising in vitro activity against atypical mycobacterial strains A Imramovský, J Vinšová, JM Férriz, R Doležal, J Jampílek, J Kaustová, ... Bioorganic & medicinal chemistry 17 (10), 3572-3579, 2009 | 66 | 2009 |
| Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment L Hroch, P Guest, O Benek, O Soukup, J Janockova, R Dolezal, K Kuca, ... Bioorganic & Medicinal Chemistry 25 (3), 1143-1152, 2017 | 58 | 2017 |
| Profiling donepezil template into multipotent hybrids with antioxidant properties E Mezeiova, K Spilovska, E Nepovimova, L Gorecki, O Soukup, R Dolezal, ... Journal of enzyme inhibition and medicinal chemistry 33 (1), 583-606, 2018 | 52 | 2018 |
| Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies R Dolezal, O Soukup, D Malinak, RML Savedra, J Marek, M Dolezalova, ... European journal of medicinal chemistry 121, 699-711, 2016 | 51 | 2016 |
| Novel tacrine-scutellarin hybrids as multipotent anti-Alzheimer’s agents: Design, synthesis and biological evaluation K Spilovska, J Korabecny, V Sepsova, D Jun, M Hrabinova, P Jost, ... Molecules 22 (6), 1006, 2017 | 50 | 2017 |
| 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment J Korabecny, M Andrs, E Nepovimova, R Dolezal, K Babkova, A Horova, ... Molecules 20 (12), 22084-22101, 2015 | 50 | 2015 |
| Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study V Sepsova, JZ Karasova, J Korabecny, R Dolezal, F Zemek, BJ Bennion, ... International journal of molecular sciences 14 (8), 16882-16900, 2013 | 46 | 2013 |
| Orexin supplementation in narcolepsy treatment: a review E Nepovimova, J Janockova, J Misik, S Kubik, A Stuchlik, K Vales, ... Medicinal research reviews 39 (3), 961-975, 2019 | 45 | 2019 |
| 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity D Malinak, R Dolezal, J Marek, S Salajkova, O Soukup, M Vejsova, ... Bioorganic & medicinal chemistry letters 24 (22), 5238-5241, 2014 | 45 | 2014 |
| Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006–2016) L Gorecki, J Korabecny, K Musilek, E Nepovimova, D Malinak, T Kucera, ... Expert opinion on therapeutic patents 27 (9), 971-985, 2017 | 40 | 2017 |
| Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: A novel cholinesterase inhibitors for the treatment of Alzheimer’s disease K Spilovska, J Korabecny, A Horova, K Musilek, E Nepovimova, ... Medicinal Chemistry Research 24, 2645-2655, 2015 | 40 | 2015 |
| Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment L Hroch, O Benek, P Guest, L Aitken, O Soukup, J Janockova, K Musil, ... Bioorganic & medicinal chemistry letters 26 (15), 3675-3678, 2016 | 39 | 2016 |
| Synthesis and disinfection effect of the pyridine-4-aldoxime based salts J Marek, D Malinak, R Dolezal, O Soukup, M Pasdiorova, M Dolezal, ... Molecules 20 (3), 3681-3696, 2015 | 38 | 2015 |
