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Bernard Pirard
Bernard Pirard
Investigator III, Novartis
Dirección de correo verificada de novartis.com
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Structural basis for the highly selective inhibition of MMP-13
CK Engel, B Pirard, S Schimanski, R Kirsch, J Habermann, O Klingler, ...
Chemistry & biology 12 (2), 181-189, 2005
2602005
Molecular basis for Kv1. 5 channel block: conservation of drug binding sites among voltage-gated K+ channels
N Decher, B Pirard, F Bundis, S Peukert, KH Baringhaus, AE Busch, ...
Journal of Biological Chemistry 279 (1), 394-400, 2004
1592004
Classification of kinase inhibitors using BCUT descriptors
B Pirard, SD Pickett
Journal of Chemical Information and Computer Sciences 40 (6), 1431-1440, 2000
1282000
Computational approaches towards the rational design of drug-like compound libraries
H Matter, KH Barighaus, T Naumann, T Klabunde, B Pirard
Combinatorial chemistry & high throughput screening 4 (6), 453-475, 2001
1232001
Insight into the structural determinants for selective inhibition of matrix metalloproteinases
B Pirard
Drug discovery today 12 (15-16), 640-646, 2007
1192007
Binding site of a novel Kv1. 5 blocker: a “foot in the door” against atrial fibrillation
N Decher, P Kumar, T Gonzalez, B Pirard, MC Sanguinetti
Molecular pharmacology 70 (4), 1204-1211, 2006
1162006
Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1. 5
S Peukert, J Brendel, B Pirard, A Brüggemann, P Below, HW Kleemann, ...
Journal of medicinal chemistry 46 (4), 486-498, 2003
1082003
A structure-based design approach to the development of novel, reversible AChE inhibitors
C Doucet-Personeni, PD Bentley, RJ Fletcher, A Kinkaid, G Kryger, ...
Journal of Medicinal Chemistry 44 (20), 3203-3215, 2001
772001
Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1. 5 channel
S Peukert, J Brendel, B Pirard, C Strübing, HW Kleemann, T Böhme, ...
Bioorganic & medicinal chemistry letters 14 (11), 2823-2827, 2004
712004
Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis
B Pirard, H Matter
Journal of medicinal chemistry 49 (1), 51-69, 2006
652006
The discovery of Kv1. 5 blockers as a case study for the application of virtual screening approaches
B Pirard, J Brendel, S Peukert
Journal of chemical information and modeling 45 (2), 477-485, 2005
542005
A database study of intermolecular NH⋯ O hydrogen bonds for carboxylates, sulfonates and monohydrogen phosphonates
B Pirard, G Baudoux, F Durant
Acta Crystallographica Section B: Structural Science 51 (1), 103-107, 1995
531995
N-((6-amino-pyridin-3-yl) methyl)-heteroaryl-carboxamides
T Brandl, S Flohr, S Kopec, J Lachal, C Markert, K Namoto, P Nganga, ...
US Patent 9,290,485, 2016
412016
New pyrazolo [1, 5a] pyrimidines as orally active inhibitors of Lck
N Gommermann, P Buehlmayer, A Von Matt, W Breitenstein, K Masuya, ...
Bioorganic & medicinal chemistry letters 20 (12), 3628-3631, 2010
312010
Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis
B Pirard
Journal of computer-aided molecular design 17 (11), 785-796, 2003
312003
5-Membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
S Flohr, C Markert, K Namoto, B Pirard
US Patent App. 14/371,457, 2014
252014
Computational methods for the identification and optimisation of high quality leads
B Pirard
Combinatorial Chemistry & High Throughput Screening 7 (4), 271-280, 2004
252004
The quest for novel chemical matter and the contribution of computer-aided de novo design
B Pirard
Expert Opinion on Drug Discovery 6 (3), 225-231, 2011
222011
CAVIAR: a method for automatic cavity detection, description and decomposition into subcavities
JR Marchand, B Pirard, P Ertl, F Sirockin
Journal of Computer-Aided Molecular Design 35 (6), 737-750, 2021
202021
3-Benzo [b] furyl-and 3-benzo [b] thienylaminobutyric acids as GABAB ligands. Synthesis and structure-activity relationship studies
M Ansar, S Al Akoum Ebriki, R Mouhoub, P Berthelot, C Vaccher, ...
European journal of medicinal chemistry 31 (6), 449-460, 1996
191996
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