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| Disruption of IRS-2 causes type 2 diabetes in mice DJ Withers, JS Gutierrez, H Towery, DJ Burks, JM Ren, S Previs, Y Zhang, ... Nature 391 (6670), 900-904, 1998 | 2112 | 1998 |
| The insulin signaling system. MF White, CR Kahn Journal of Biological Chemistry 269 (1), 1-4, 1994 | 2102 | 1994 |
| Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein XJ Sun, P Rothenberg, CR Kahn, JM Backer, E Araki, PA Wilden, ... Nature 352 (6330), 73-77, 1991 | 2031 | 1991 |
| Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle C Yu, Y Chen, GW Cline, D Zhang, H Zong, Y Wang, R Bergeron, JK Kim, ... Journal of Biological Chemistry 277 (52), 50230-50236, 2002 | 1895 | 2002 |
| The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307 V Aguirre, T Uchida, L Yenush, R Davis, MF White Journal of Biological Chemistry 275 (12), 9047-9054, 2000 | 1888 | 2000 |
| Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, ... Diabetes 48 (6), 1270-1274, 1999 | 1654 | 1999 |
| IRS proteins and the common path to diabetes MF White American Journal of Physiology-Endocrinology and Metabolism 283 (3), E413-E422, 2002 | 1287 | 2002 |
| Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action V Aguirre, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White Journal of Biological Chemistry 277 (2), 1531-1537, 2002 | 1258 | 2002 |
| SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 L Rui, M Yuan, D Frantz, S Shoelson, MF White Journal of Biological Chemistry 277 (44), 42394-42398, 2002 | 1168 | 2002 |
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| Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 KD Copps, MF White Diabetologia 55, 2565-2582, 2012 | 1055 | 2012 |
| Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents K Morino, KF Petersen, S Dufour, D Befroy, J Frattini, N Shatzkes, ... The Journal of clinical investigation 115 (12), 3587-3593, 2005 | 1009 | 2005 |
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| Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats ZY Jiang, YW Lin, A Clemont, EP Feener, KD Hein, M Igarashi, ... The Journal of clinical investigation 104 (4), 447-457, 1999 | 761 | 1999 |
C. Ronald KahnJoslin Diabetes Center and Harvard Medical SchoolVerified email at joslin.harvard.edu
