Seguir
Nathanael Gray
Nathanael Gray
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Dirección de correo verificada de dfci.harvard.edu
Título
Citado por
Citado por
Año
Targeting cancer with small molecule kinase inhibitors
J Zhang, PL Yang, NS Gray
Nature reviews cancer 9 (1), 28-39, 2009
29442009
Systematic identification of genomic markers of drug sensitivity in cancer cells
MJ Garnett, EJ Edelman, SJ Heidorn, CD Greenman, A Dastur, KW Lau, ...
Nature 483 (7391), 570-575, 2012
22592012
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ...
Journal of Biological Chemistry 284 (12), 8023-8032, 2009
18502009
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ...
Cell 171 (6), 1437-1452. e17, 2017
16512017
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
TR Peterson, M Laplante, CC Thoreen, Y Sancak, SA Kang, WM Kuehl, ...
Cell 137 (5), 873-886, 2009
13842009
A unifying model for mTORC1-mediated regulation of mRNA translation
CC Thoreen, L Chantranupong, HR Keys, T Wang, NS Gray, DM Sabatini
Nature 485 (7396), 109-113, 2012
13532012
A landscape of pharmacogenomic interactions in cancer
F Iorio, TA Knijnenburg, DJ Vis, GR Bignell, MP Menden, M Schubert, ...
Cell 166 (3), 740-754, 2016
12262016
Rational design of inhibitors that bind to inactive kinase conformations
Y Liu, NS Gray
Nature chemical biology 2 (7), 358-364, 2006
11852006
A chemical switch for inhibitor-sensitive alleles of any protein kinase
AC Bishop, JA Ubersax, DT Petsch, DP Matheos, NS Gray, J Blethrow, ...
nature 407 (6802), 395-401, 2000
11652000
EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer
JP Koivunen, C Mermel, K Zejnullahu, C Murphy, E Lifshits, AJ Holmes, ...
Clinical cancer research 14 (13), 4275-4283, 2008
11232008
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
NS Gray, L Wodicka, AMWH Thunnissen, TC Norman, S Kwon, ...
Science 281 (5376), 533-538, 1998
11191998
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
PP Hsu, SA Kang, J Rameseder, Y Zhang, KA Ottina, D Lim, TR Peterson, ...
Science 332 (6035), 1317-1322, 2011
10942011
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ...
Nature 462 (7276), 1070-1074, 2009
10662009
Activating mutations in ALK provide a therapeutic target in neuroblastoma
RE George, T Sanda, M Hanna, S Fröhling, WL Ii, J Zhang, Y Ahn, ...
Nature 455 (7215), 975-978, 2008
9162008
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
TW Theunissen, BE Powell, H Wang, M Mitalipova, DA Faddah, J Reddy, ...
Cell stem cell 15 (4), 471-487, 2014
7542014
MEK1 mutations confer resistance to MEK and B-RAF inhibition
CM Emery, KG Vijayendran, MC Zipser, AM Sawyer, L Niu, JJ Kim, ...
Proceedings of the National Academy of Sciences 106 (48), 20411-20416, 2009
7032009
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate
MG Sanna, J Liao, E Jo, C Alfonso, MY Ahn, MS Peterson, B Webb, ...
Journal of Biological Chemistry 279 (14), 13839-13848, 2004
6902004
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
6792015
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
N Kwiatkowski, T Zhang, PB Rahl, BJ Abraham, J Reddy, SB Ficarro, ...
Nature 511 (7511), 616-620, 2014
6492014
A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase InhibitorsResistance Mechanisms in ALK Kinase Inhibitors
T Sasaki, J Koivunen, A Ogino, M Yanagita, S Nikiforow, W Zheng, ...
Cancer research 71 (18), 6051-6060, 2011
6302011
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
Artículos 1–20