David H. Spencer
David H. Spencer
Assistant Professor, Division of Oncology, Department of Medicine, Washington University
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
CK Stover, XQ Pham, AL Erwin, SD Mizoguchi, P Warrener, MJ Hickey, ...
Nature 406 (6799), 959-964, 2000
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Cancer Genome Atlas Research Network
New England Journal of Medicine 368 (22), 2059-2074, 2013
Comprehensive transposon mutant library of Pseudomonas aeruginosa
MA Jacobs, A Alwood, I Thaipisuttikul, D Spencer, E Haugen, S Ernst, ...
Proceedings of the National Academy of Sciences 100 (24), 14339-14344, 2003
CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
M Griffith, NC Spies, K Krysiak, JF McMichael, AC Coffman, AM Danos, ...
Nature genetics 49 (2), 170-174, 2017
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
DA Russler-Germain, DH Spencer, MA Young, TL Lamprecht, CA Miller, ...
Cancer cell 25 (4), 442-454, 2014
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients
DA D'Argenio, M Wu, LR Hoffman, HD Kulasekara, E Déziel, EE Smith, ...
Molecular microbiology 64 (2), 512-533, 2007
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia
JM Klco, DH Spencer, CA Miller, M Griffith, TL Lamprecht, M O’Laughlin, ...
Cancer cell 25 (3), 379-392, 2014
Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia
JM Klco, CA Miller, M Griffith, A Petti, DH Spencer, S Ketkar-Kulkarni, ...
Jama 314 (8), 811-822, 2015
Whole-Genome Sequence Variation among Multiple Isolates of Pseudomonas aeruginosa
DH Spencer, A Kas, EE Smith, CK Raymond, EH Sims, M Hastings, ...
Journal of bacteriology 185 (4), 1316-1325, 2003
Clinical next‐generation sequencing in patients with non–small cell lung cancer
IS Hagemann, S Devarakonda, CM Lockwood, DH Spencer, K Guebert, ...
Cancer 121 (4), 631-639, 2015
Genetic Variation at the O-Antigen Biosynthetic Locus in Pseudomonas aeruginosa
CK Raymond, EH Sims, A Kas, DH Spencer, TV Kutyavin, RG Ivey, ...
Journal of bacteriology 184 (13), 3614-3622, 2002
Evidence for Diversifying Selection at the Pyoverdine Locus of Pseudomonas aeruginosa
EE Smith, EH Sims, DH Spencer, R Kaul, MV Olson
Journal of bacteriology 187 (6), 2138-2147, 2005
Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens
DH Spencer, JK Sehn, HJ Abel, MA Watson, JD Pfeifer, EJ Duncavage
The Journal of molecular diagnostics 15 (5), 623-633, 2013
Validation of a next-generation sequencing assay for clinical molecular oncology
CE Cottrell, H Al-Kateb, AJ Bredemeyer, EJ Duncavage, DH Spencer, ...
The Journal of molecular diagnostics 16 (1), 89-105, 2014
CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression
DH Spencer, DA Russler-Germain, S Ketkar, NM Helton, TL Lamprecht, ...
Cell 168 (5), 801-816. e13, 2017
Genomic impact of transient low-dose decitabine treatment on primary AML cells
JM Klco, DH Spencer, TL Lamprecht, SM Sarkaria, T Wylie, V Magrini, ...
Blood, The Journal of the American Society of Hematology 121 (9), 1633-1643, 2013
Performance of common analysis methods for detecting low-frequency single nucleotide variants in targeted next-generation sequence data
DH Spencer, M Tyagi, F Vallania, AJ Bredemeyer, JD Pfeifer, RD Mitra, ...
The Journal of Molecular Diagnostics 16 (1), 75-88, 2014
Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data
DH Spencer, HJ Abel, CM Lockwood, JE Payton, P Szankasi, TW Kelley, ...
The Journal of molecular diagnostics 15 (1), 81-93, 2013
Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis
RK Ernst, DA D′ Argenio, JK Ichikawa, MG Bangera, S Selgrade, ...
Environmental microbiology 5 (12), 1341-1349, 2003
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells
DH Spencer, MA Young, TL Lamprecht, NM Helton, R Fulton, ...
Leukemia 29 (6), 1279-1289, 2015
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Artículos 1–20