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Glyn Hemsworth
Glyn Hemsworth
Verified email at leeds.ac.uk
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A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes
J Larsbrink, TE Rogers, GR Hemsworth, LS McKee, AS Tauzin, O Spadiut, ...
Nature 506 (7489), 498-502, 2014
4962014
Discovery and characterization of a new family of lytic polysaccharide monooxygenases
GR Hemsworth, B Henrissat, GJ Davies, PH Walton
Nature chemical biology 10 (2), 122-126, 2014
4262014
The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases
KEH Frandsen, TJ Simmons, P Dupree, JCN Poulsen, GR Hemsworth, ...
Nature chemical biology 12 (4), 298-303, 2016
3432016
Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase
L Lo Leggio, TJ Simmons, JCN Poulsen, KEH Frandsen, GR Hemsworth, ...
Nature communications 6 (1), 5961, 2015
3242015
Lytic polysaccharide monooxygenases in biomass conversion
GR Hemsworth, EM Johnston, GJ Davies, PH Walton
Trends in biotechnology 33 (12), 747-761, 2015
3182015
An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion
F Sabbadin, GR Hemsworth, L Ciano, B Henrissat, P Dupree, T Tryfona, ...
Nature communications 9 (1), 756, 2018
2552018
Recent insights into copper-containing lytic polysaccharide mono-oxygenases
GR Hemsworth, GJ Davies, PH Walton
Current opinion in structural biology 23 (5), 660-668, 2013
2432013
Spectroscopic and computational insight into the activation of O2 by the mononuclear Cu center in polysaccharide monooxygenases
CH Kjaergaard, MF Qayyum, SD Wong, F Xu, GR Hemsworth, DJ Walton, ...
Proceedings of the National Academy of Sciences 111 (24), 8797-8802, 2014
2382014
The copper active site of CBM33 polysaccharide oxygenases
GR Hemsworth, EJ Taylor, RQ Kim, RC Gregory, SJ Lewis, JP Turkenburg, ...
Journal of the American Chemical Society 135 (16), 6069-6077, 2013
2182013
Molecular mechanism by which prominent human gut bacteroidetes utilize mixed-linkage beta-glucans, major health-promoting cereal polysaccharides
K Tamura, GR Hemsworth, G Déjean, TE Rogers, NA Pudlo, K Urs, N Jain, ...
Cell reports 21 (2), 417-430, 2017
1412017
Structural and functional insight into human O-GlcNAcase
C Roth, S Chan, WA Offen, GR Hemsworth, LI Willems, DT King, ...
Nature chemical biology 13 (6), 610-612, 2017
1082017
Learning from microbial strategies for polysaccharide degradation
GR Hemsworth, G Dejean, GJ Davies, H Brumer
Biochemical Society Transactions 44 (1), 94-108, 2016
902016
Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody
B Carpenter, GR Hemsworth, Z Wu, M Maamra, CJ Strasburger, RJ Ross, ...
Structure 20 (3), 487-497, 2012
882012
Heterogeneity in the histidine-brace copper coordination sphere in auxiliary activity family 10 (AA10) lytic polysaccharide monooxygenases
AK Chaplin, MT Wilson, MA Hough, DA Svistunenko, GR Hemsworth, ...
Journal of Biological Chemistry 291 (24), 12838-12850, 2016
692016
Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut
GR Hemsworth, AJ Thompson, J Stepper, ŁF Sobala, T Coyle, J Larsbrink, ...
Open Biology 6 (7), 160142, 2016
592016
Activity, stability and 3-D structure of the Cu (II) form of a chitin-active lytic polysaccharide monooxygenase from Bacillus amyloliquefaciens
RC Gregory, GR Hemsworth, JP Turkenburg, SJ Hart, PH Walton, ...
Dalton Transactions 45 (42), 16904-16912, 2016
552016
Structural enzymology of Cellvibrio japonicus Agd31B protein reveals α-transglucosylase activity in glycoside hydrolase family 31
J Larsbrink, A Izumi, GR Hemsworth, GJ Davies, H Brumer
Journal of Biological Chemistry 287 (52), 43288-43299, 2012
532012
The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine
GR Hemsworth, OV Moroz, MJ Fogg, B Scott, C Bosch-Navarrete, ...
Journal of Biological Chemistry 286 (18), 16470-16481, 2011
442011
Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases
KEH Frandsen, M Tovborg, CI Jørgensen, N Spodsberg, MN Rosso, ...
Journal of Biological Chemistry 294 (45), 17117-17130, 2019
352019
Discovery, activity and characterisation of an AA10 lytic polysaccharide oxygenase from the shipworm symbiont Teredinibacter turnerae
CA Fowler, F Sabbadin, L Ciano, GR Hemsworth, L Elias, N Bruce, ...
Biotechnology for biofuels 12, 1-11, 2019
342019
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