| A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ... Cell, 2020 | 259 | 2020 |
| Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ... Nature Communications 10 (1), 3468, 2019 | 146 | 2019 |
| A smart “off–on” gate for the in situ detection of hydrogen sulphide with Cu (II)-assisted europium emission Z Liang, TH Tsoi, CF Chan, L Dai, Y Wu, G Du, L Zhu, CS Lee, WT Wong, ... Chemical Science 7 (3), 2151-2156, 2016 | 63 | 2016 |
| Selective degradation of GSPT1 by cereblon modulators identified via a focused combinatorial library CE Powell, G Du, J Che, Z He, KA Donovan, H Yue, ES Wang, RP Nowak, ... ACS Chemical Biology 15 (10), 2722-2730, 2020 | 58 | 2020 |
| Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth The Journal of Clinical Investigation, 2018 | 58 | 2018 |
| Construction of the Tricyclic Furanochroman Skeleton of Phomactin A via the Prins/Conia-Ene Cascade Cyclization Approach S Huang, G Du, CS Lee The Journal of organic chemistry 76 (16), 6534-6541, 2011 | 49 | 2011 |
| Leveraging compound promiscuity to identify targetable cysteines within the kinome S Rao, D Gurbani, G Du, RA Everley, CM Browne, A Chaikuad, L Tan, ... Cell chemical biology 26 (6), 818-829. e9, 2019 | 45 | 2019 |
| Exploring the target scope of KEAP1 E3 ligase-based PROTACs G Du, J Jiang, NJ Henning, N Safaee, E Koide, RP Nowak, KA Donovan, ... Cell Chemical Biology 29 (10), 1470-1481. e31, 2022 | 37 | 2022 |
| Structure-guided development of covalent TAK1 inhibitors L Tan, D Gurbani, EL Weisberg, JC Hunter, L Li, DS Jones, SB Ficarro, ... Bioorganic & medicinal chemistry 25 (3), 838-846, 2017 | 33 | 2017 |
| Bioinspired total synthesis of (±)-Yezo’otogirin C S He, W Yang, L Zhu, G Du, CS Lee Organic letters 16 (2), 496-499, 2014 | 32 | 2014 |
| Discovery of a potent degrader for fibroblast growth factor receptor 1/2 G Du, J Jiang, Q Wu, NJ Henning, KA Donovan, H Yue, J Che, W Lu, ... Angewandte Chemie 133 (29), 16041-16047, 2021 | 29 | 2021 |
| Structure-based design of a potent and selective covalent inhibitor for SRC kinase that targets a P-loop cysteine G Du, S Rao, D Gurbani, NJ Henning, J Jiang, J Che, A Yang, SB Ficarro, ... Journal of Medicinal Chemistry 63 (4), 1624-1641, 2020 | 24 | 2020 |
| Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors L Tan, D Gurbani, EL Weisberg, DS Jones, S Rao, WD Singer, ... Bioorganic & medicinal chemistry 25 (4), 1320-1328, 2017 | 21 | 2017 |
| A Bifunctional Lewis Acid Induced Cascade Cyclization to the Tricyclic Core of ent-Kaurenoids and Its Application to the Formal Synthesis of (±)-Platensimycin L Zhu, Y Han, G Du, CS Lee Organic letters 15 (3), 524-527, 2013 | 21 | 2013 |
| Structure and Characterization of a Covalent Inhibitor of Src Kinase D Gurbani, G Du, NJ Henning, S Rao, AK Bera, T Zhang, NS Gray, ... Frontiers in Molecular Biosciences 7, 81, 2020 | 19 | 2020 |
| Selective degradation-inducing probes for studying cereblon (CRBN) biology CE Powell, G Du, JW Bushman, Z He, T Zhang, ES Fischer, NS Gray RSC Medicinal Chemistry 12 (8), 1381-1390, 2021 | 18 | 2021 |
| Syntheses of diverse natural products via dual-mode Lewis acid induced cascade cyclization reactions G Du, G Wang, W Ma, Q Yang, W Bao, X Liang, L Zhu, CS Lee Synlett 28 (12), 1394-1406, 2017 | 18 | 2017 |
| Peptide-based covalent inhibitors of MALT1 paracaspase JM Hatcher, G Du, L Fontán, I Us, Q Qiao, S Chennamadhavuni, J Shao, ... Bioorganic & medicinal chemistry letters 29 (11), 1336-1339, 2019 | 17 | 2019 |
| Formal Synthesis of (+)-Phomactin A J Huang, W Bao, S Huang, W Yang, Z Lizhi, G Du, CS Lee Organic letters 20 (23), 7466-7469, 2018 | 17 | 2018 |
| Quinoline and thiazolopyridine allosteric inhibitors of MALT1 DA Scott, JM Hatcher, H Liu, M Fu, G Du, L Fontán, I Us, G Casalena, ... Bioorganic & medicinal chemistry letters 29 (14), 1694-1698, 2019 | 16 | 2019 |
Katherine A DonovanDana-Farber Cancer Institute, Harvard Medical SchoolDirección de correo verificada de crystal.harvard.edu
