Christian Hundhausen, PhD
Christian Hundhausen, PhD
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The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
C Hundhausen, D Misztela, TA Berkhout, N Broadway, P Saftig, K Reiss, ...
Blood 102 (4), 1186-1195, 2003
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
V Matthews, B Schuster, S Schütze, I Bussmeyer, A Ludwig, ...
Journal of biological chemistry 278 (40), 38829-38839, 2003
The transmembrane CXC-chemokine ligand 16 is induced by IFN-γ and TNF-α and shed by the activity of the disintegrin-like metalloproteinase ADAM10
S Abel, C Hundhausen, R Mentlein, A Schulte, TA Berkhout, N Broadway, ...
The Journal of Immunology 172 (10), 6362-6372, 2004
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell …
A Ludwig, C Hundhausen, MH Lambert, N Broadway, RC Andrews, ...
Combinatorial chemistry & high throughput screening 8 (2), 161-171, 2005
Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis
U Laggner, P Di Meglio, GK Perera, C Hundhausen, KE Lacy, N Ali, ...
The Journal of Immunology 187 (5), 2783-2793, 2011
Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes
C Hundhausen, A Schulte, B Schulz, MG Andrzejewski, N Schwarz, ...
The Journal of Immunology 178 (12), 8064-8072, 2007
Progress in understanding the immunopathogenesis of psoriasis
RKH Mak, C Hundhausen, FO Nestle
Actas dermo-sifiliograficas 100, 2-13, 2009
Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells
A Ludwig, A Schulte, C Schnack, C Hundhausen, K Reiss, N Brodway, ...
Journal of neurochemistry 93 (5), 1293-1303, 2005
Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by α-and γ-secretases
A Schulte, B Schulz, MG Andrzejewski, C Hundhausen, S Mletzko, ...
Biochemical and biophysical research communications 358 (1), 233-240, 2007
The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity
JA Gorman, C Hundhausen, JS Errett, AE Stone, EJ Allenspach, Y Ge, ...
Nature immunology 18 (7), 744-752, 2017
Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression
C Hundhausen, A Roth, E Whalen, J Chen, A Schneider, SA Long, S Wei, ...
Science translational medicine 8 (356), 356ra119-356ra119, 2016
Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin
F Scholz, A Schulte, F Adamski, C Hundhausen, J Mittag, A Schwarz, ...
Journal of Investigative Dermatology 127 (6), 1444-1455, 2007
A systems model for immune cell interactions unravels the mechanism of inflammation in human skin
NV Valeyev, C Hundhausen, Y Umezawa, NV Kotov, G Williams, A Clop, ...
PLoS computational biology 6 (12), e1001024, 2010
An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element
A Clop, A Bertoni, SL Spain, MA Simpson, V Pullabhatla, R Tonda, ...
PLoS One 8 (8), e71690, 2013
Integrative biology approach identifies cytokine targeting strategies for psoriasis
GK Perera, C Ainali, E Semenova, C Hundhausen, G Barinaga, D Kassen, ...
Science translational medicine 6 (223), 223ra22-223ra22, 2014
Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis
C Hundhausen, A Bertoni, RK Mak, E Botti, P Di Meglio, A Clop, ...
Journal of investigative dermatology 132 (3), 635-641, 2012
Abatacept targets T follicular helper and regulatory T cells, disrupting molecular pathways that regulate their proliferation and maintenance
S Glatigny, B Höllbacher, SJ Motley, C Tan, C Hundhausen, JH Buckner, ...
The Journal of Immunology 202 (5), 1373-1382, 2019
The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets
JA Gorman, C Hundhausen, M Kinsman, T Arkatkar, EJ Allenspach, ...
Frontiers in immunology 10, 44, 2019
Computational modelling elucidates the mechanism of ciliary regulation in health and disease
NV Kotov, DG Bates, AN Gizatullina, B Gilaziev, RN Khairullin, MZQ Chen, ...
BMC Systems Biology 5 (1), 1-26, 2011
Endothelial hyaluronan synthase 3 augments postischemic arteriogenesis through CD44/eNOS signaling
R Schneckmann, T Suvorava, C Hundhausen, D Schuler, C Lorenz, ...
Arteriosclerosis, Thrombosis, and Vascular Biology 41 (10), 2551-2562, 2021
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