John Asara
John Asara
Associate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical Center
Verified email at
Cited by
Cited by
HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, JM Asara, ...
Science 292 (5516), 464-468, 2001
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
DF Egan, DB Shackelford, MM Mihaylova, S Gelino, RA Kohnz, W Mair, ...
Science 331 (6016), 456-461, 2011
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ...
Cell 149 (3), 656-670, 2012
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ...
Nature 496 (7443), 101-105, 2013
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
VS LeBleu, JT O’Connell, KN Gonzalez Herrera, H Wikman, K Pantel, ...
Nature cell biology 16 (10), 992-1003, 2014
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
H Sano, S Kane, E Sano, CP Mı̂inea, JM Asara, WS Lane, CW Garner, ...
Journal of Biological Chemistry 278 (17), 14599-14602, 2003
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ...
Science 334 (6060), 1278-1283, 2011
Pyruvate kinase M2 is a phosphotyrosine-binding protein
HR Christofk, MG Vander Heiden, N Wu, JM Asara, LC Cantley
Nature 452 (7184), 181-186, 2008
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
A Viale, P Pettazzoni, CA Lyssiotis, H Ying, N Sánchez, M Marchesini, ...
Nature 514 (7524), 628-632, 2014
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ...
Nature genetics 43 (9), 869-874, 2011
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
CM Sousa, DE Biancur, X Wang, CJ Halbrook, MH Sherman, L Zhang, ...
Nature 536 (7617), 479-483, 2016
A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue
M Yuan, SB Breitkopf, X Yang, JM Asara
Nature protocols 7 (5), 872-881, 2012
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ...
Science 350 (6266), 1391-1396, 2015
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
I Ben-Sahra, JJ Howell, JM Asara, BD Manning
Science 339 (6125), 1323-1328, 2013
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
MG Vander Heiden, JW Locasale, KD Swanson, H Sharfi, GJ Heffron, ...
Science 329 (5998), 1492-1499, 2010
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning
Science 351 (6274), 728-733, 2016
A method to identify serine kinase substrates: Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
S Kane, H Sano, SCH Liu, JM Asara, WS Lane, CC Garner, GE Lienhard
Journal of Biological Chemistry 277 (25), 22115-22118, 2002
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
JR Molina, Y Sun, M Protopopova, S Gera, M Bandi, C Bristow, T McAfoos, ...
Nature medicine 24 (7), 1036-1046, 2018
Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates
DF Egan, MGH Chun, M Vamos, H Zou, J Rong, CJ Miller, HJ Lou, ...
Molecular cell 59 (2), 285-297, 2015
The system can't perform the operation now. Try again later.
Articles 1–20