John Asara

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Lewis CantleyDana Farber Cancer Center and Harvard Medical SchoolVerified email at med.cornell.edu
Costas LyssiotisAssociate Professor of Physiology, University of MichiganVerified email at lyssiotis.com
Brendan D. ManningHarvard UniversityVerified email at hsph.harvard.edu
Jason LocasaleDuke UniversityVerified email at alum.mit.edu
William S. LaneHarvard University, MSPRL Director (Mass Spectrometry & Proteomics Resource Lab)Verified email at harvard.edu
Wenyi WeiProfessor, Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolVerified email at bidmc.harvard.edu
Issam Ben-SahraNorthwestern UniversityVerified email at northwestern.edu
Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
Alex TokerVerified email at bidmc.harvard.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineVerified email at med.cornell.edu
Pengda LiuUniversity of North Carolina at Chapel HillVerified email at med.unc.edu
Reuben ShawThe Salk Institute of Biological StudiesVerified email at salk.edu
Gerburg WulfAssociate Professor in Medicine, Harvard Medical SchoolVerified email at bidmc.harvard.edu
Shyh-Chang, NgInstitute of Zoology (IOZ), Institute of Stem cells & Regeneration (ISCR), UCAS, CASVerified email at ioz.ac.cn
Bin ZhengCedars-Sinai Medical CenterVerified email at cshs.org
David J. KwiatkowskiProfessor of Medicine, Harvard Medical SchoolVerified email at rics.bwh.harvard.edu
Mary Higby SchweitzerProfessor, Department of Biological Sciences, North Carolina State UniversityVerified email at ncsu.edu
Atsuo T. SasakiUniversity of Cincinnati, College of MedicineVerified email at uc.edu
Mircea IvanIndiana UniversityVerified email at iu.edu
Elizabeth P HenskeProfessor of Medicine, Harvard Medical SchoolVerified email at bwh.harvard.edu

John Asara

Associate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical Center

Verified email at bidmc.harvard.edu

Metabolomics Lipidomics Proteomics Mass Spectrometry Biochemistry


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HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, JM Asara, ... Science 292 (5516), 464-468, 2001	5678	2001
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy DF Egan, DB Shackelford, MM Mihaylova, S Gelino, RA Kohnz, W Mair, ... Science 331 (6016), 456-461, 2011	2582	2011
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ... Cell 149 (3), 656-670, 2012	1897	2012
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ... Nature 496 (7443), 101-105, 2013	1824	2013
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis VS LeBleu, JT O’Connell, KN Gonzalez Herrera, H Wikman, K Pantel, ... Nature cell biology 16 (10), 992-1003, 2014	1263	2014
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation H Sano, S Kane, E Sano, CP Mı̂inea, JM Asara, WS Lane, CW Garner, ... Journal of Biological Chemistry 278 (17), 14599-14602, 2003	1219	2003
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ... Science 334 (6060), 1278-1283, 2011	1181	2011
Pyruvate kinase M2 is a phosphotyrosine-binding protein HR Christofk, MG Vander Heiden, N Wu, JM Asara, LC Cantley Nature 452 (7184), 181-186, 2008	1138	2008
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function A Viale, P Pettazzoni, CA Lyssiotis, H Ying, N Sánchez, M Marchesini, ... Nature 514 (7524), 628-632, 2014	1131	2014
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ... Nature genetics 43 (9), 869-874, 2011	1109	2011
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion CM Sousa, DE Biancur, X Wang, CJ Halbrook, MH Sherman, L Zhang, ... Nature 536 (7617), 479-483, 2016	932	2016
A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue M Yuan, SB Breitkopf, X Yang, JM Asara Nature protocols 7 (5), 872-881, 2012	914	2012
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ... Science 350 (6266), 1391-1396, 2015	833	2015
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1 I Ben-Sahra, JJ Howell, JM Asara, BD Manning Science 339 (6125), 1323-1328, 2013	756	2013
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012	743	2012
Evidence for an alternative glycolytic pathway in rapidly proliferating cells MG Vander Heiden, JW Locasale, KD Swanson, H Sharfi, GJ Heffron, ... Science 329 (5998), 1492-1499, 2010	723	2010
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning Science 351 (6274), 728-733, 2016	685	2016
A method to identify serine kinase substrates: Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain S Kane, H Sano, SCH Liu, JM Asara, WS Lane, CC Garner, GE Lienhard Journal of Biological Chemistry 277 (25), 22115-22118, 2002	674	2002
An inhibitor of oxidative phosphorylation exploits cancer vulnerability JR Molina, Y Sun, M Protopopova, S Gera, M Bandi, C Bristow, T McAfoos, ... Nature medicine 24 (7), 1036-1046, 2018	661	2018
Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates DF Egan, MGH Chun, M Vamos, H Zou, J Rong, CJ Miller, HJ Lou, ... Molecular cell 59 (2), 285-297, 2015	640	2015

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