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Rajarshi Guha
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Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
Y Yang, AL Shaffer III, NCT Emre, M Ceribelli, M Zhang, G Wright, W Xiao, ...
Cancer cell 21 (6), 723-737, 2012
5362012
Recent developments of the chemistry development kit (CDK)-an open-source java library for chemo-and bioinformatics
C Steinbeck, C Hoppe, S Kuhn, M Floris, R Guha, EL Willighagen
Current pharmaceutical design 12 (17), 2111-2120, 2006
5272006
The Blue Obelisk—interoperability in chemical informatics
R Guha, MT Howard, GR Hutchison, P Murray-Rust, H Rzepa, ...
Journal of chemical information and modeling 46 (3), 991-998, 2006
4872006
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
LA Mathews Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, ...
Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014
3662014
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
SA Hasson, LA Kane, K Yamano, CH Huang, DA Sliter, E Buehler, ...
Nature 504 (7479), 291-295, 2013
3382013
The Chemistry Development Kit (CDK) v2. 0: atom typing, depiction, molecular formulas, and substructure searching
EL Willighagen, JW Mayfield, J Alvarsson, A Berg, L Carlsson, ...
Journal of cheminformatics 9 (1), 1-19, 2017
3062017
Structure− activity landscape index: identifying and quantifying activity cliffs
R Guha, JH Van Drie
Journal of chemical information and modeling 48 (3), 646-658, 2008
3052008
Unexplored therapeutic opportunities in the human genome
TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ...
Nature reviews Drug discovery 17 (5), 317-332, 2018
2692018
Chemical informatics functionality in R
R Guha
Journal of Statistical Software 18, 1-16, 2007
2482007
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond
WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ...
PLoS Pathog 12 (7), e1005763, 2016
2402016
What are we ‘tweeting’about obesity? Mapping tweets with topic modeling and Geographic Information System
D Ghosh, R Guha
Cartography and geographic information science 40 (2), 90-102, 2013
2362013
RNA polymerase II regulates topoisomerase 1 activity to favor efficient transcription
L Baranello, D Wojtowicz, K Cui, BN Devaiah, HJ Chung, KY Chan-Salis, ...
Cell 165 (2), 357-371, 2016
2302016
Pharos: collating protein information to shed light on the druggable genome
DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, ...
Nucleic acids research 45 (D1), D995-D1002, 2017
2032017
PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain VulnerabilityPAX3–FOXO1 Establishes Super Enhancers and BRD4 Dependency
BE Gryder, ME Yohe, HC Chou, X Zhang, J Marques, M Wachtel, ...
Cancer Discovery 7 (8), 884-899, 2017
1962017
Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome
GW Rhyasen, L Bolanos, J Fang, A Jerez, M Wunderlich, C Rigolino, ...
Cancer cell 24 (1), 90-104, 2013
1872013
Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors
M Ceribelli, PN Kelly, AL Shaffer, GW Wright, W Xiao, Y Yang, ...
Proceedings of the National Academy of Sciences 111 (31), 11365-11370, 2014
1862014
Navigating structure–activity landscapes
J Bajorath, L Peltason, M Wawer, R Guha, MS Lajiness, JH Van Drie
Drug discovery today 14 (13-14), 698-705, 2009
1782009
PubChem as a source of polypharmacology
B Chen, D Wild, R Guha
Journal of chemical information and modeling 49 (9), 2044-2055, 2009
1602009
ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses
R Jossé, SE Martin, R Guha, P Ormanoglu, TD Pfister, PM Reaper, ...
Cancer research 74 (23), 6968-6979, 2014
1592014
Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives
KC Bulusu, R Guha, DJ Mason, RPI Lewis, E Muratov, YK Motamedi, ...
Drug discovery today 21 (2), 225-238, 2016
1572016
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