| IDH mutation impairs histone demethylation and results in a block to cell differentiation C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ... Nature 483 (7390), 474-478, 2012 | 1834 | 2012 |
| A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma DM O’Rourke, MLP Nasrallah, A Desai, JJ Melenhorst, K Mansfield, ... Science translational medicine 9 (399), eaaa0984, 2017 | 1022 | 2017 |
| Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial M Weller, N Butowski, DD Tran, LD Recht, M Lim, H Hirte, L Ashby, ... The Lancet Oncology 18 (10), 1373-1385, 2017 | 662 | 2017 |
| A patient-derived glioblastoma organoid model and biobank recapitulates inter-and intra-tumoral heterogeneity F Jacob, RD Salinas, DY Zhang, PTT Nguyen, JG Schnoll, SZH Wong, ... Cell 180 (1), 188-204. e22, 2020 | 337 | 2020 |
| Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving … A Maity, N Pore, J Lee, D Solomon, DM O’Rourke Cancer research 60 (20), 5879-5886, 2000 | 326 | 2000 |
| Induction of ischemic tolerance following brief focal ischemia in rat brain SS Glazier, DM O'Rourke, DI Graham, FA Welsh Journal of Cerebral Blood Flow & Metabolism 14 (4), 545-553, 1994 | 286 | 1994 |
| Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1–independent mechanism N Pore, S Liu, HK Shu, B Li, D Haas-Kogan, D Stokoe, J Milanini-Mongiat, ... Molecular biology of the cell 15 (11), 4841-4853, 2004 | 276 | 2004 |
| Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo BW Park, HT Zhang, C Wu, A Berezov, X Zhang, R Dua, Q Wang, G Kao, ... Nature biotechnology 18 (2), 194-198, 2000 | 253 | 2000 |
| Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques L Macyszyn, H Akbari, JM Pisapia, X Da, M Attiah, V Pigrish, Y Bi, S Pal, ... Neuro-oncology 18 (3), 417-425, 2015 | 241 | 2015 |
| Intraaxial Brain Masses: MR Imaging–based Diagnostic Strategy—Initial Experience1 RN Al-Okaili, J Krejza, JH Woo, RL Wolf, DM O'Rourke, KD Judy, ... Radiology 243 (2), 539-550, 2007 | 216 | 2007 |
| PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating … N Pore, S Liu, DA Haas-Kogan, DM O’Rourke, A Maity Cancer research 63 (1), 236-241, 2003 | 203 | 2003 |
| Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla RL Wolf, J Wang, S Wang, ER Melhem, DM O'Rourke, KD Judy, JA Detre Journal of Magnetic Resonance Imaging: An Official Journal of the …, 2005 | 196 | 2005 |
| Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging S Wang, S Kim, S Chawla, RL Wolf, DE Knipp, A Vossough, DM O'Rourke, ... American Journal of Neuroradiology 32 (3), 507-514, 2011 | 179 | 2011 |
| Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging S Wang, S Kim, S Chawla, RL Wolf, WG Zhang, DM O'Rourke, KD Judy, ... Neuroimage 44 (3), 653-660, 2009 | 169 | 2009 |
| The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors CJ Wu, DM O'Rourke, GS Feng, GR Johnson, Q Wang, MI Greene Oncogene 20 (42), 6018-6025, 2001 | 166 | 2001 |
| Constitutive EGFR signaling confers a motile phenotype to neural stem cells JA Boockvar, D Kapitonov, G Kapoor, J Schouten, GJ Counelis, O Bogler, ... Molecular and Cellular Neuroscience 24 (4), 1116-1130, 2003 | 148 | 2003 |
| Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells A Ayuso-Sacido, JA Moliterno, S Kratovac, GS Kapoor, DM O’Rourke, ... Journal of neuro-oncology 97 (3), 323-337, 2010 | 144 | 2010 |
| CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges SJ Bagley, AS Desai, GP Linette, CH June, DM O’Rourke Neuro-oncology 20 (11), 1429-1438, 2018 | 143 | 2018 |
| Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters β-tubulin isotype expression RB Montgomery, J Guzman, DM O'Rourke, WL Stahl Journal of Biological chemistry 275 (23), 17358-17363, 2000 | 135 | 2000 |
| Compositions and methods of treating tumors MI Greene, DM O'rourke, R Murali, BW Park US Patent 6,417,168, 2002 | 131* | 2002 |
Christos DavatzikosDirector, Center for Biomedical Image Computing and Analytics, Professor of Radiology, andDirección de correo verificada de pennmedicine.upenn.edu
