| HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, JM Asara, ... Science 292 (5516), 464-468, 2001 | 5678 | 2001 |
| Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein M Ohh, CW Park, M Ivan, MA Hoffman, TY Kim, LE Huang, N Pavletich, ... Nature cell biology 2 (7), 423-427, 2000 | 1905 | 2000 |
| A microRNA signature of hypoxia R Kulshreshtha, M Ferracin, SE Wojcik, R Garzon, H Alder, ... Molecular and cellular biology 27 (5), 1859-1867, 2007 | 1288 | 2007 |
| Structure of an HIF-1α-pVHL complex: hydroxyproline recognition in signaling J Min, H Yang, M Ivan, F Gertler, WG Kaelin Jr, NP Pavletich Science 296 (5574), 1886-1889, 2002 | 913 | 2002 |
| Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor M Ivan, T Haberberger, DC Gervasi, KS Michelson, V Günzler, K Kondo, ... Proceedings of the National Academy of Sciences 99 (21), 13459-13464, 2002 | 703 | 2002 |
| MicroRNA regulation of DNA repair gene expression in hypoxic stress ME Crosby, R Kulshreshtha, M Ivan, PM Glazer Cancer research 69 (3), 1221-1229, 2009 | 507 | 2009 |
| von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF MA Hoffman, M Ohh, H Yang, JM Klco, M Ivan, WG Kaelin Jr Human molecular genetics 10 (10), 1019-1027, 2001 | 449 | 2001 |
| MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways X Rao, G Di Leva, M Li, F Fang, C Devlin, C Hartman-Frey, ME Burow, ... Oncogene 30 (9), 1082-1097, 2011 | 405 | 2011 |
| MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU E Favaro, A Ramachandran, R McCormick, H Gee, C Blancher, M Crosby, ... PloS one 5 (4), e10345, 2010 | 350 | 2010 |
| A microRNA component of the hypoxic response R Kulshreshtha, RV Davuluri, GA Calin, M Ivan Cell Death & Differentiation 15 (4), 667-671, 2008 | 322 | 2008 |
| miR‐210: More than a silent player in hypoxia C Devlin, S Greco, F Martelli, M Ivan IUBMB life 63 (2), 94-100, 2011 | 315 | 2011 |
| An integrated approach for experimental target identification of hypoxia-induced miR-210 P Fasanaro, S Greco, M Lorenzi, M Pescatori, M Brioschi, R Kulshreshtha, ... Journal of Biological Chemistry 284 (50), 35134-35143, 2009 | 315 | 2009 |
| Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock CR Mantel, HA O’Leary, BR Chitteti, XX Huang, S Cooper, G Hangoc, ... Cell 161 (7), 1553-1565, 2015 | 284 | 2015 |
| The von Hippel–Lindau tumor suppressor protein M Ivan, WG Kaelin Jr Current opinion in genetics & development 11 (1), 27-34, 2001 | 279 | 2001 |
| Hypoxia response and microRNAs: no longer two separate worlds M Ivan, AL Harris, F Martelli, R Kulshreshtha Journal of cellular and molecular medicine 12 (5a), 1426-1431, 2008 | 248 | 2008 |
| microRNA: emerging therapeutic targets in acute ischemic diseases P Fasanaro, S Greco, M Ivan, MC Capogrossi, F Martelli Pharmacology & therapeutics 125 (1), 92-104, 2010 | 231 | 2010 |
| Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER T Van Den Beucken, E Koch, K Chu, R Rupaimoole, P Prickaerts, ... Nature communications 5 (1), 5203, 2014 | 222 | 2014 |
| The EGLN-HIF O2-sensing system: multiple inputs and feedbacks M Ivan, WG Kaelin Molecular cell 66 (6), 772-779, 2017 | 215 | 2017 |
| Regulatory mechanisms of microRNAs involvement in cancer: the strange case of Dr Jekyll and Mr Hyde M Fabbri, M Ivan, A Cimmino, M Negrini, GA Calin Expert opinion on biological therapy 7 (7), 1009-1019, 2007 | 205 | 2007 |
| Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells M Ivan, JA Bond, M Prat, PM Comoglio, D Wynford-Thomas Oncogene 14 (20), 2417-2423, 1997 | 201 | 1997 |
Ramana V DavuluriProfessor of Biomedical Informatics, State University of New York at Stony Brook, Stony Brook, NYVerified email at stonybrookmedicine.edu
