| Unexplored therapeutic opportunities in the human genome TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ... Nature reviews Drug discovery 17 (5), 317-332, 2018 | 360 | 2018 |
| Rare variant contribution to human disease in 281,104 UK Biobank exomes Q Wang, RS Dhindsa, K Carss, AR Harper, A Nag, I Tachmazidou, ... Nature 597 (7877), 527-532, 2021 | 245 | 2021 |
| Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications D Muthas, A Reznichenko, CA Balendran, G Böttcher, IG Clausen, ... Scandinavian journal of gastroenterology 52 (2), 125-135, 2017 | 163 | 2017 |
| Functionalized 3-amino-imidazo [1, 2-a] pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors LR Odell, MT Nilsson, J Gising, O Lagerlund, D Muthas, A Nordqvist, ... Bioorganic & Medicinal Chemistry Letters 19 (16), 4790-4793, 2009 | 128 | 2009 |
| DrugPred: a structure-based approach to predict protein druggability developed using an extensive nonredundant data set A Krasowski, D Muthas, A Sarkar, S Schmitt, R Brenk Journal of chemical information and modeling 51 (11), 2829-2842, 2011 | 98 | 2011 |
| Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes H Garside, KF Marcoe, J Chesnut-Speelman, AJ Foster, D Muthas, ... Toxicology in Vitro 28 (2), 171-181, 2014 | 94 | 2014 |
| Scope and limitations of Baird's theory on triplet state aromaticity: application to the tuning of singlet–triplet energy gaps in fulvenes H Ottosson, K Kilså, K Chajara, MC Piqueras, R Crespo, H Kato, ... Chemistry–A European Journal 13 (24), 6998-7005, 2007 | 90 | 2007 |
| Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients C Winkler, T Hochdörfer, E Israelsson, A Hasselberg, A Cavallin, K Thörn, ... Journal of Allergy and Clinical Immunology 144 (1), 61-69. e7, 2019 | 80 | 2019 |
| Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering? An investigation of the advantages and pitfalls of post-filtering D Muthas, YA Sabnis, M Lundborg, A Karlén Journal of Molecular Graphics and Modelling 26 (8), 1237-1251, 2008 | 69 | 2008 |
| Synthesis, biological evaluation and X-ray crystallographic studies of imidazo [1, 2-a] pyridine-based Mycobacterium tuberculosis glutamine synthetase inhibitors A Nordqvist, MT Nilsson, O Lagerlund, D Muthas, J Gising, S Yahiaoui, ... MedChemComm 3 (5), 620-626, 2012 | 48 | 2012 |
| Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II D Muthas, D Nöteberg, YA Sabnis, E Hamelink, L Vrang, B Samuelsson, ... Bioorganic & medicinal chemistry 13 (18), 5371-5390, 2005 | 48 | 2005 |
| A critical assessment of modeling safety-related drug attrition D Muthas, S Boyer, C Hasselgren MedChemComm 4 (7), 1058-1065, 2013 | 41 | 2013 |
| Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase J Nurbo, AK Roos, D Muthas, E Wahlström, DJ Ericsson, T Lundstedt, ... Journal of peptide science: an official publication of the European Peptide …, 2007 | 40 | 2007 |
| Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis RS Dhindsa, J Mattsson, A Nag, Q Wang, LV Wain, R Allen, EM Wigmore, ... Communications biology 4 (1), 392, 2021 | 38 | 2021 |
| Fungal dysbiosis and intestinal inflammation in children with beta-cell autoimmunity J Honkanen, A Vuorela, D Muthas, L Orivuori, K Luopajärvi, MVG Tejesvi, ... Frontiers in Immunology 11, 468, 2020 | 31 | 2020 |
| Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes R Riise, L Odqvist, J Mattsson, S Monkley, SM Abdillahi, C Tyrchan, ... Scientific Reports 9 (1), 20407, 2019 | 29 | 2019 |
| Dysregulation of COVID-19 related gene expression in the COPD lung A Watson, L Öberg, B Angermann, CM Spalluto, M Hühn, H Burke, ... Respiratory research 22 (1), 164, 2021 | 25 | 2021 |
| Application of data mining and visualization techniques for the prediction of drug-induced nausea in man J Parkinson, D Muthas, M Clark, S Boyer, JP Valentin, L Ewart Toxicological Sciences 126 (1), 275-284, 2012 | 23 | 2012 |
| Focused hierarchical design of peptide libraries—follow the lead D Muthas, PM Lek, J Nurbo, A Karlén, T Lundstedt Journal of Chemometrics: A Journal of the Chemometrics Society 21 (10‐11 …, 2007 | 19 | 2007 |
| MODifieR: an ensemble R package for inference of disease modules from transcriptomics networks HA de Weerd, TVS Badam, D Martínez-Enguita, J Åkesson, D Muthas, ... Bioinformatics 36 (12), 3918-3919, 2020 | 17 | 2020 |
