| On the rate and extent of drug delivery to the brain M Hammarlund-Udenaes, M Fridén, S Syvänen, A Gupta Pharmaceutical research 25, 1737-1750, 2008 | 515 | 2008 |
| Structure− brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids M Fridén, S Winiwarter, G Jerndal, O Bengtsson, H Wan, U Bredberg, ... Journal of medicinal chemistry 52 (20), 6233-6243, 2009 | 228 | 2009 |
| In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids M Friden, A Gupta, M Antonsson, U Bredberg, M Hammarlund-Udenaes Drug metabolism and disposition 35 (9), 1711-1719, 2007 | 208 | 2007 |
| Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods M Fridén, F Bergström, H Wan, M Rehngren, G Ahlin, ... Drug Metabolism and Disposition 39 (3), 353-362, 2011 | 176 | 2011 |
| Development of a high-throughput brain slice method for studying drug distribution in the central nervous system M Friden, F Ducrozet, B Middleton, M Antonsson, U Bredberg, ... Drug metabolism and disposition 37 (6), 1226-1233, 2009 | 146 | 2009 |
| Improved measurement of drug exposure in the brain using drug-specific correction for residual blood M Fridén, H Ljungqvist, B Middleton, U Bredberg, ... Journal of Cerebral Blood Flow & Metabolism 30 (1), 150-161, 2010 | 116 | 2010 |
| The brain slice method for studying drug distribution in the CNS I Loryan, M Fridén, M Hammarlund-Udenaes Fluids and Barriers of the CNS 10, 1-9, 2013 | 90 | 2013 |
| Methodologies to assess brain drug delivery in lead optimization M Hammarlund-Udenaes, U Bredberg, M Fridén Current topics in medicinal chemistry 9 (2), 148-162, 2009 | 82 | 2009 |
| Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs E Boger, N Evans, M Chappell, A Lundqvist, P Ewing, A Wigenborg, ... CPT: pharmacometrics & systems pharmacology 5 (4), 201-210, 2016 | 76 | 2016 |
| In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms H Chen, S Winiwarter, M Fridén, M Antonsson, O Engkvist Journal of Molecular Graphics and Modelling 29 (8), 985-995, 2011 | 67 | 2011 |
| Physiologically based pharmacokinetic/pharmacodynamic modeling accurately predicts the better bronchodilatory effect of inhaled versus oral salbutamol dosage forms E Boger, M Fridén Journal of aerosol medicine and pulmonary drug delivery 32 (1), 1-12, 2019 | 49 | 2019 |
| Development of a novel lung slice methodology for profiling of inhaled compounds E Bäckström, A Lundqvist, E Boger, P Svanberg, P Ewing, ... Journal of pharmaceutical sciences 105 (2), 838-845, 2016 | 45 | 2016 |
| Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the first workshop on drug transporters in the lungs C Ehrhardt, P Bäckman, W Couet, C Edwards, B Forbes, M Fridén, ... Journal of Pharmaceutical Sciences 106 (9), 2234-2244, 2017 | 44 | 2017 |
| Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development I Loryan, A Reichel, B Feng, C Bundgaard, C Shaffer, C Kalvass, ... Pharmaceutical research 39 (7), 1321-1341, 2022 | 38 | 2022 |
| Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation S Varadharajan, S Winiwarter, L Carlsson, O Engkvist, A Anantha, ... Journal of Pharmaceutical Sciences 104 (3), 1197-1206, 2015 | 37 | 2015 |
| Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators R Hendrickx, E Lamm Bergström, DLI Janzén, M Fridén, U Eriksson, ... CPT: pharmacometrics & systems pharmacology 7 (3), 147-157, 2018 | 36 | 2018 |
| Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain M Fridén, M Wennerberg, M Antonsson, M Sandberg-Ställ, L Farde, ... EJNMMI research 4, 1-8, 2014 | 36 | 2014 |
| Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations A Lindqvist, M Fridén, M Hammarlund-Udenaes European Journal of Pharmaceutical Sciences 92, 173-182, 2016 | 28 | 2016 |
| C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats S Stridh, J Sällström, M Fridén, P Hansell, L Nordquist, F Palm Oxygen transport to tissue xxx, 219-225, 2009 | 28 | 2009 |
| Lung retention by lysosomal trapping of inhaled drugs can be predicted in vitro with lung slices E Bäckström, E Boger, A Lundqvist, M Hammarlund-Udenaes, M Fridén Journal of pharmaceutical sciences 105 (11), 3432-3439, 2016 | 27 | 2016 |
