Leticia G. Leon
Leticia G. Leon
Netherland Cancer Institute (NKI)
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MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
E Giovannetti, N Funel, GJ Peters, M Del Chiaro, LA Erozenci, E Vasile, ...
Cancer research 70 (11), 4528-4538, 2010
Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer
JH Hwang, J Voortman, E Giovannetti, SM Steinberg, LG Leon, YT Kim, ...
PloS one 5 (5), e10630, 2010
Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells
C Granchi, S Roy, C Giacomelli, M Macchia, T Tuccinardi, A Martinelli, ...
Journal of medicinal chemistry 54 (6), 1599-1612, 2011
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
M Maftouh, A Avan, R Sciarrillo, C Granchi, LG Leon, R Rani, N Funel, ...
British journal of cancer 110 (1), 172-182, 2014
High-Throughput MicroRNA (miRNAs) Arrays Unravel the Prognostic Role of MiR-211 in Pancreatic Cancer.
PGJ Giovannetti E, van der Velde A, Funel N, Vasile E
PloS One 7 (11), e49145, 2012
Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol
EL Bonifazi, C Ríos-Luci, LG León, G Burton, JM Padrón, RI Misico
Bioorganic & medicinal chemistry 18 (7), 2621-2630, 2010
Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer
D Massihnia, A Avan, N Funel, M Maftouh, A Van Krieken, C Granchi, ...
Journal of Hematology & Oncology 10, 1-17, 2017
Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines
IC Guerrero, LS Andrés, LG León, RP Machín, JM Padrón, JG Luis, ...
Journal of natural products 69 (12), 1803-1805, 2006
Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: A platform for drug testing
M Rovithi, A Avan, N Funel, LG Leon, VE Gomez, T Wurdinger, ...
Scientific reports 7 (1), 44686, 2017
Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients
C Tibaldi, E Giovannetti, M Tiseo, LG Leon, A D'incecco, N Loosekoot, ...
Annals of oncology 23 (3), 670-677, 2012
Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol
CR Pungitore, LG León, C García, VS Martín, CE Tonn, JM Padrón
Bioorganic & medicinal chemistry letters 17 (5), 1332-1335, 2007
Heterometallic platinum (II) compounds with β-aminoethylferrocenes: synthesis, electrochemical behaviour and anticancer activity
D Nieto, AM González-Vadillo, S Bruña, CJ Pastor, C Ríos-Luci, LG León, ...
Dalton Transactions 41 (2), 432-441, 2012
Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy
E Giovannetti, P Pacetti, M Reni, LG Leon, A Mambrini, E Vasile, ...
Pharmacogenomics 12 (12), 1641-1652, 2011
Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin
E Giovannetti, PA Zucali, YG Assaraf, LG Leon, K Smid, C Alecci, ...
British journal of cancer 105 (10), 1542-1553, 2011
Molecular simplification in bioactive molecules: formal synthesis of (+)-muconin
FR Pinacho Crisóstomo, R Carrillo, LG León, T Martín, JM Padrón, ...
The Journal of Organic Chemistry 71 (6), 2339-2345, 2006
Antiproliferative and structure activity relationships of Amaryllidaceae alkaloids
JC Cedrón, ÁG Ravelo, LG León, JM Padrón, A Estévez-Braun
Molecules 20 (8), 13854-13863, 2015
β-Lapachone analogs with enhanced antiproliferative activity
C Ríos-Luci, EL Bonifazi, LG Leon, JC Montero, G Burton, A Pandiella, ...
European journal of medicinal chemistry 53, 264-274, 2012
Reactivity and Biological Properties of a Series of Cytotoxic PtI2(amine)2 Complexes, Either cis or trans Configured
L Messori, L Cubo, C Gabbiani, A Alvarez-Valdes, E Michelucci, ...
Inorganic Chemistry 51 (3), 1717-1726, 2012
NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor
E Galvani, J Sun, LG Leon, R Sciarrillo, RS Narayan, RTT Sjin, K Lee, ...
Oncotarget 6 (40), 42717, 2015
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model
LJA Toonen, M Overzier, MM Evers, LG Leon, SAJ van der Zeeuw, H Mei, ...
Molecular Neurodegeneration 13, 1-18, 2018
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