David Ron
David Ron
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Signal integration in the endoplasmic reticulum unfolded protein response
D Ron, P Walter
Nature reviews Molecular cell biology 8 (7), 519-529, 2007
The unfolded protein response: from stress pathway to homeostatic regulation
P Walter, D Ron
science 334 (6059), 1081-1086, 2011
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
HP Harding, Y Zhang, D Ron
Nature 397 (6716), 271-274, 1999
Regulated translation initiation controls stress-induced gene expression in mammalian cells
HP Harding, I Novoa, Y Zhang, H Zeng, R Wek, M Schapira, D Ron
Molecular cell 6 (5), 1099-1108, 2000
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding, Y Zhang, H Zeng, I Novoa, PD Lu, M Calfon, N Sadri, C Yun, ...
Molecular cell 11 (3), 619-633, 2003
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
F Urano, XZ Wang, A Bertolotti, Y Zhang, P Chung, HP Harding, D Ron
science 287 (5453), 664-666, 2000
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
A Bertolotti, Y Zhang, LM Hendershot, HP Harding, D Ron
Nature cell biology 2 (6), 326-332, 2000
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon, H Zeng, F Urano, JH Till, SR Hubbard, HP Harding, SG Clark, ...
Nature 415 (6867), 92-96, 2002
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
I Tabas, D Ron
Nature cell biology 13 (3), 184-190, 2011
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
H Zinszner, M Kuroda, XZ Wang, N Batchvarova, RT Lightfoot, H Remotti, ...
Genes & development 12 (7), 982-995, 1998
Perk is essential for translational regulation and cell survival during the unfolded protein response
HP Harding, Y Zhang, A Bertolotti, H Zeng, D Ron
Molecular cell 5 (5), 897-904, 2000
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
SJ Marciniak, CY Yun, S Oyadomari, I Novoa, Y Zhang, R Jungreis, ...
Genes & development 18 (24), 3066-3077, 2004
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
J Nangalia, CE Massie, EJ Baxter, FL Nice, G Gundem, DC Wedge, ...
New England Journal of Medicine 369 (25), 2391-2405, 2013
A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress
M Boyce, KF Bryant, C Jousse, K Long, HP Harding, D Scheuner, ...
Science 307 (5711), 935-939, 2005
Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
I Novoa, H Zeng, HP Harding, D Ron
The Journal of cell biology 153 (5), 1011-1022, 2001
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene …
D Ron, JF Habener
Genes & development 6 (3), 439-453, 1992
Diabetes mellitus and exocrine pancreatic dysfunction in perk−/− mice reveals a role for translational control in secretory cell survival
HP Harding, H Zeng, Y Zhang, R Jungries, P Chung, H Plesken, ...
Molecular cell 7 (6), 1153-1163, 2001
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2, 3-dioxygenase
DH Munn, MD Sharma, B Baban, HP Harding, Y Zhang, D Ron, AL Mellor
Immunity 22 (5), 633-642, 2005
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Y Ye, Y Shibata, C Yun, D Ron, TA Rapoport
Nature 429 (6994), 841-847, 2004
Transcriptional and translational control in the mammalian unfolded protein response
HP Harding, M Calfon, F Urano, I Novoa, D Ron
Annual review of cell and developmental biology 18 (1), 575-599, 2002
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