Chuan-Hsiang Bear Huang
Chuan-Hsiang Bear Huang
Associate Professor, Johns Hopkins University
Verified email at - Homepage
Cited by
Cited by
The Structure of a Human p110 {alpha}/p85 {alpha} Complex Elucidates the Effects of Oncogenic PI3K {alpha} Mutations
CH Huang, D Mandelker, O Schmidt-Kittler, Y Samuels, VE Velculescu, ...
Science 318 (5857), 1744, 2007
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
KF Swaney*, CH Huang*, PN Devreotes
Annual review of biophysics 39, 265-289, 2010
A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane
D Mandelker, SB Gabelli, O Schmidt-Kittler, J Zhu, I Cheong, CH Huang, ...
Proceedings of the National Academy of Sciences 106 (40), 16996-17001, 2009
Cells navigate with a local-excitation, global-inhibition-biased excitable network
Y Xiong, CH Huang, PA Iglesias, PN Devreotes
Proceedings of the National Academy of Sciences 107 (40), 17079-17086, 2010
An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration
CH Huang, M Tang, C Shi, PA Iglesias, PN Devreotes
Nature cell biology 15 (11), 1307-1316, 2013
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells
C Shi, CH Huang, PN Devreotes, PA Iglesias
PLoS computational biology 9 (7), e1003122, 2013
Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope
CH Huang, S Peng, L He, YC Tsai, DAK Boyd, TH Hansen, TC Wu, ...
Gene therapy 12 (15), 1180-1186, 2005
Structural comparisons of class I phosphoinositide 3-kinases
LM Amzel*, CH Huang*, D Mandelker, C Lengauer, SB Gabelli, ...
Nature Reviews Cancer 8 (9), 665-669, 2008
Insights into the oncogenic effects of/PIK3CA/mutations from the structure of p110α/p85α
CH Huang, D Mandelker, SB Gabelli, LM Amzel
Cell Cycle 7 (9), 1151-1156, 2008
Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis
M Tang, M Wang, C Shi, PA Iglesias, PN Devreotes, CH Huang
Nature communications 5, 5175, 2014
NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin
P Schiapparelli, H Guerrero-Cazares, R Magaņa-Maldonado, SM Hamilla, ...
EBioMedicine 21, 94-103, 2017
An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells
H Zhan, S Bhattacharya, H Cai, PA Iglesias, CH Huang*, PN Devreotes*
Developmental Cell, 2020
Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
JM Yang, S Bhattacharya, H West-Foyle, CF Hung, TC Wu, PA Iglesias, ...
Nature Communications 9 (1), 4673, 2018
Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 …
S Peng, L Ferrall, S Gaillard, C Wang, WY Chi, CH Huang, RBS Roden, ...
Mbio 12 (1), 2021
Binding of nitrogen‐containing bisphosphonates (N‐BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer
CH Huang, SB Gabelli, E Oldfield, LM Amzel
Proteins: Structure, Function, and Bioinformatics 78 (4), 888-899, 2010
Gβ regulates coupling between actin oscillators for cell polarity and directional migration
O Hoeller, JE Toettcher, H Cai, Y Sun, CH Huang, M Freyre, M Zhao, ...
PLoS biology 14 (2), e1002381, 2016
Analysis of chemotaxis in Dictyostelium
H Cai, CH Huang, PN Devreotes, M Iijima
Integrin and Cell Adhesion Molecules: Methods and Protocols, 451-468, 2012
Deciphering cell signaling networks with massively multiplexed biosensor barcoding
JM Yang, WY Chi, J Liang, S Takayanagi, PA Iglesias, CH Huang
Cell, 2021
Structural effects of oncogenic PI3Kα mutations
SB Gabelli, CH Huang, D Mandelker, O Schmidt-Kittler, B Vogelstein, ...
Phosphoinositide 3-kinase in Health and Disease, 43-53, 2010
Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway
Y Yu, YS Rahmanto, MH Lee, PH Wu, JM Phillip, CH Huang, MI Vitolo, ...
Oncogene, 1, 2018
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Articles 1–20