| Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design AL Ferguson, JK Mann, S Omarjee, T Ndung’u, BD Walker, ... Immunity 38 (3), 606-617, 2013 | 248 | 2013 |
| The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing JK Mann, JP Barton, AL Ferguson, S Omarjee, BD Walker, A Chakraborty, ... PLoS computational biology 10 (8), e1003776, 2014 | 158 | 2014 |
| Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence R Payne, M Muenchhoff, J Mann, HE Roberts, P Matthews, E Adland, ... Proceedings of the National Academy of Sciences 111 (50), E5393-E5400, 2014 | 110 | 2014 |
| Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes JK Mann, H Byakwaga, XT Kuang, AQ Le, CJ Brumme, P Mwimanzi, ... Retrovirology 10, 1-16, 2013 | 88 | 2013 |
| Selection of an HLA-C* 03: 04-restricted HIV-1 p24 gag sequence variant is associated with viral escape from KIR2DL3+ natural killer cells: data from an observational cohort in … A Hölzemer, CF Thobakgale, CA Jimenez Cruz, WF Garcia-Beltran, ... PLoS medicine 12 (11), e1001900, 2015 | 77 | 2015 |
| Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection DM Muema, NA Akilimali, OC Ndumnego, SS Rasehlo, R Durgiah, ... BMC medicine 18, 1-17, 2020 | 74 | 2020 |
| HIV-1 vaccine immunogen design strategies JK Mann, T Ndung’u Virology journal 12, 1-11, 2015 | 72 | 2015 |
| The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19 JK Mann, T Ndung'u Future Virology 15 (9), 609-624, 2020 | 52 | 2020 |
| Subtype-specific differences in Gag-protease-driven replication capacity are consistent with intersubtype differences in HIV-1 disease progression MW Kiguoya, JK Mann, D Chopera, K Gounder, GQ Lee, PW Hunt, ... Journal of virology 91 (13), 10.1128/jvi. 00253-17, 2017 | 40 | 2017 |
| Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure JK Mann, D Chopera, S Omarjee, XT Kuang, AQ Le, G Anmole, R Danroth, ... Virology 468, 214-225, 2014 | 34 | 2014 |
| Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5 SW Jin, FM Mwimanzi, JK Mann, MB Bwana, GQ Lee, CJ Brumme, ... PLoS pathogens 16 (9), e1008813, 2020 | 26 | 2020 |
| High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection K Gounder, N Padayachi, JK Mann, M Radebe, M Mokgoro, ... PloS one 10 (3), e0119886, 2015 | 20 | 2015 |
| Dual HLA B* 42 and B* 81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants F Ogunshola, G Anmole, RL Miller, E Goering, T Nkosi, D Muema, J Mann, ... Nature communications 9 (1), 5023, 2018 | 14 | 2018 |
| Pol-driven replicative capacity impacts disease progression in HIV-1 subtype C infection DBA Ojwach, D MacMillan, T Reddy, V Novitsky, ZL Brumme, ... Journal of virology 92 (19), 10.1128/jvi. 00811-18, 2018 | 14 | 2018 |
| Mother-to-child HIV transmission bottleneck selects for consensus virus with lower gag-protease-driven replication capacity VL Naidoo, JK Mann, C Noble, E Adland, JM Carlson, J Thomas, ... Journal of virology 91 (17), 10.1128/jvi. 00518-17, 2017 | 14 | 2017 |
| No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial DR Chopera, JK Mann, P Mwimanzi, S Omarjee, XT Kuang, N Ndabambi, ... PloS one 8 (8), e71758, 2013 | 14 | 2013 |
| Resistance of major histocompatibility complex class B (MHC-B) to Nef-mediated downregulation relative to that of MHC-A is conserved among primate lentiviruses and influences … F Mwimanzi, M Toyoda, M Mahiti, JK Mann, JN Martin, D Bangsberg, ... Journal of virology 92 (1), 10.1128/jvi. 01409-17, 2018 | 13 | 2018 |
| Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C JK Mann, S Omarjee, P Khumalo, T Ndung’u Virology journal 12, 1-8, 2015 | 12 | 2015 |
| Modelling and in vitro testing of the HIV-1 Nef fitness landscape JP Barton, E Rajkoomar, JK Mann, DK Murakowski, M Toyoda, M Mahiti, ... Virus evolution 5 (2), vez029, 2019 | 11 | 2019 |
| Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness DR Chopera, LA Cotton, A Zawaira, JK Mann, NK Ngandu, R Ntale, ... Journal of virology 86 (24), 13423-13433, 2012 | 11 | 2012 |
