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Nicholas Holmes
Nicholas Holmes
Research Fellow, University of Leeds
Dirección de correo verificada de leeds.ac.uk
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Machine learning meets continuous flow chemistry: Automated optimization towards the Pareto front of multiple objectives
AM Schweidtmann, AD Clayton, N Holmes, E Bradford, RA Bourne, ...
Chemical Engineering Journal 352, 277-282, 2018
2992018
Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors
N Holmes, GR Akien, RJD Savage, C Stanetty, IR Baxendale, AJ Blacker, ...
Reaction Chemistry & Engineering 1 (1), 96-100, 2016
1322016
Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor
N Holmes, GR Akien, AJ Blacker, RL Woodward, RE Meadows, ...
Reaction Chemistry & Engineering 1 (4), 366-371, 2016
1162016
Rapid multistep kinetic model generation from transient flow data
CA Hone, N Holmes, GR Akien, RA Bourne, FL Muller
Reaction chemistry & engineering 2 (2), 103-108, 2017
932017
Enhanced process development using automated continuous reactors by self-optimisation algorithms and statistical empirical modelling
MI Jeraal, N Holmes, GR Akien, RA Bourne
Tetrahedron 74 (25), 3158-3164, 2018
442018
Efficient and selective oxidation of sulfides in batch and continuous flow using styrene-based polymer immobilised ionic liquid phase supported peroxotungstates
S Doherty, JG Knight, MA Carroll, AR Clemmet, JR Ellison, T Backhouse, ...
RSC advances 6 (77), 73118-73131, 2016
302016
Analysis and Optimisation of Continuous Processes
N HOLMES, RA BOURNE
Chemical Processes for a Sustainable Future, 28, 2014
22014
Self-Optimisation of Automated Continuous Reactors
N Holmes
University of Leeds, 2017
2017
Self-optimizing flow reactors in pharmaceutical development for rapid process optimization
N Holmes, R Bourne, J Blacker, R Meadows, R Woodward
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
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