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Alexander Eggel
Alexander Eggel
Verified email at dbmr.unibe.ch
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Cited by
Year
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
SA Villeda, J Luo, KI Mosher, B Zou, M Britschgi, G Bieri, TM Stan, ...
Nature 477 (7362), 90-94, 2011
18372011
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
LK Smith, Y He, JS Park, G Bieri, CE Snethlage, K Lin, G Gontier, R Wabl, ...
Nature medicine 21 (8), 932-937, 2015
4532015
NADPH oxidase–independent formation of extracellular DNA traps by basophils
M Morshed, R Hlushchuk, D Simon, AF Walls, K Obata-Ninomiya, ...
The Journal of Immunology 192 (11), 5314-5323, 2014
1802014
The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab
P Gasser, SS Tarchevskaya, P Guntern, D Brigger, R Ruppli, N Zbären, ...
Nature communications 11 (1), 165, 2020
1542020
Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells
A Eggel, G Baravalle, G Hobi, B Kim, P Buschor, P Forrer, JS Shin, ...
Journal of allergy and clinical immunology 133 (6), 1709-1719. e8, 2014
1542014
Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor
B Kim, A Eggel, SS Tarchevskaya, M Vogel, H Prinz, TS Jardetzky
Nature 491 (7425), 613-617, 2012
1082012
Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
LF Pennington, S Tarchevskaya, D Brigger, K Sathiyamoorthy, ...
Nature communications 7 (1), 11610, 2016
1062016
A revival of parabiosis in biomedical research
A Eggel, T Wyss-Coray
Swiss medical weekly 144 (0506), w13914-w13914, 2014
842014
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age
D Brigger, C Riether, R van Brummelen, KI Mosher, A Shiu, Z Ding, ...
Nature metabolism 2 (8), 688-702, 2020
792020
DARPins as bispecific receptor antagonists analyzed for immunoglobulin E receptor blockage
A Eggel, MJ Baumann, P Amstutz, BM Stadler, M Vogel
Journal of molecular biology 393 (3), 598-607, 2009
702009
Inhibition of ongoing allergic reactions using a novel anti‐IgE DARPin‐Fc fusion protein
A Eggel, P Buschor, MJ Baumann, P Amstutz, BM Stadler, M Vogel
Allergy 66 (7), 961-968, 2011
612011
Past, present, and future of anti‐IgE biologics
P Guntern, A Eggel
Allergy 75 (10), 2491-2502, 2020
572020
DARPins against a functional IgE epitope
MJ Baumann, A Eggel, P Amstutz, BM Stadler, M Vogel
Immunology letters 133 (2), 78-84, 2010
542010
A novel bispecific DARP in targeting Fcγ RIIB and Fcε RI‐bound IgE inhibits allergic responses
F Zellweger, P Gasser, D Brigger, P Buschor, M Vogel, A Eggel
Allergy 72 (8), 1174-1183, 2017
522017
IgE‐associated allergic disorders: recent advances in etiology, diagnosis, and treatment
F Zellweger, A Eggel
Allergy 71 (12), 1652-1661, 2016
452016
Targeting IgE in allergic disease
P Gasser, A Eggel
Current opinion in immunology 54, 86-92, 2018
402018
Accuracy of serological testing for SARS‐CoV‐2 antibodies: first results of a large mixed‐method evaluation study
D Brigger, MP Horn, LF Pennington, AE Powell, D Siegrist, B Weber, ...
Allergy 76 (3), 853-865, 2021
362021
Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions
LF Pennington, P Gasser, D Brigger, P Guntern, A Eggel, TS Jardetzky
Journal of Allergy and Clinical Immunology 148 (4), 1049-1060, 2021
252021
A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E–receptor interactions
B Kim, SS Tarchevskaya, A Eggel, M Vogel, TS Jardetzky
Analytical biochemistry 431 (2), 84-89, 2012
252012
IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils
F Zellweger, P Buschor, G Hobi, D Brigger, CA Dahinden, PM Villiger, ...
Cell death & disease 9 (5), 510, 2018
242018
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