| Structural basis for the activation of PPARγ by oxidized fatty acids T Itoh, L Fairall, K Amin, Y Inaba, A Szanto, BL Balint, L Nagy, ... Nature structural & molecular biology 15 (9), 924-931, 2008 | 516 | 2008 |
| 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor γ agonist alleviates the symptoms of DSS-induced colitis K Yamamoto, Y Ninomiya, M Iseki, Y Nakachi, Y Kanesaki-Yatsuka, ... Biochemical and Biophysical Research Communications 367 (3), 566-572, 2008 | 160 | 2008 |
| Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents K Yamamoto, T Itoh, D Abe, M Shimizu, T Kanda, T Koyama, M Nishikawa, ... Bioorganic & medicinal chemistry letters 15 (3), 517-522, 2005 | 99 | 2005 |
| Selective inhibition of methoxyflavonoids on human CYP1B1 activity H Takemura, T Itoh, K Yamamoto, H Sakakibara, K Shimoi Bioorganic & medicinal chemistry 18 (17), 6310-6315, 2010 | 92 | 2010 |
| asymmetric synthesis of (−)-adaline T Itoh, N Yamazaki, C Kibayashi Organic Letters 4 (15), 2469-2472, 2002 | 80 | 2002 |
| Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis M Choi, K Yamamoto, T Itoh, M Makishima, DJ Mangelsdorf, D Moras, ... Chemistry & biology 10 (3), 261-270, 2003 | 71 | 2003 |
| Peroxisome proliferator activated receptor γ and oxidized docosahexaenoic acids as new class of ligand T Itoh, K Yamamoto Naunyn-Schmiedeberg's archives of pharmacology 377, 541-547, 2008 | 69 | 2008 |
| Synthesis of docosahexaenoic acid derivatives designed as novel PPARγ agonists and antidiabetic agents T Itoh, I Murota, K Yoshikai, S Yamada, K Yamamoto Bioorganic & medicinal chemistry 14 (1), 98-108, 2006 | 66 | 2006 |
| Asymmetric Synthesis of (−)-Indolizidines 167B and 209D Based on Stereocontrolled Allylation of a Chiral Tricyclic N-Acyl-N,O-acetal N Yamazaki, T Ito, C Kibayashi Organic Letters 2 (4), 465-467, 2000 | 65 | 2000 |
| Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting T Itoh, L Fairall, FW Muskett, CP Milano, PJ Watson, N Arnaudo, A Saleh, ... Nucleic Acids Research 43 (4), 2033-2044, 2015 | 62 | 2015 |
| Total synthesis of the coccinellid alkaloid (−)-adalinine and the assignment of its absolute configuration N Yamazaki, T Ito, C Kibayashi Tetrahedron letters 40 (4), 739-742, 1999 | 57 | 1999 |
| Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls H Inui, T Itoh, K Yamamoto, SI Ikushiro, T Sakaki International journal of molecular sciences 15 (8), 14044-14057, 2014 | 53 | 2014 |
| Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3, 3′, 4, 4′, 5-pentachlorobiphenyl K Yamazaki, M Suzuki, T Itoh, K Yamamoto, M Kanemitsu, C Matsumura, ... The journal of biochemistry 149 (4), 487-494, 2011 | 53 | 2011 |
| Biomimetic Total Synthesis of (±)-8-Oxoerymelanthine Y Yoshida, K Mohri, K Isobe, T Itoh, K Yamamoto The Journal of Organic Chemistry 74 (16), 6010-6015, 2009 | 50 | 2009 |
| A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22 R … Y Anami, T Itoh, D Egawa, N Yoshimoto, K Yamamoto Journal of medicinal chemistry 57 (10), 4351-4367, 2014 | 45 | 2014 |
| PPARα ligand-binding domain structures with endogenous fatty acids and fibrates S Kamata, T Oyama, K Saito, A Honda, Y Yamamoto, K Suda, R Ishikawa, ... Iscience 23 (11), 2020 | 43 | 2020 |
| A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol T Itoh, H Takemura, K Shimoi, K Yamamoto Journal of chemical information and modeling 50 (6), 1173-1178, 2010 | 42 | 2010 |
| 17-OxoDHA is a PPARα/γ dual covalent modifier and agonist D Egawa, T Itoh, Y Akiyama, T Saito, K Yamamoto ACS Chemical Biology 11 (9), 2447-2455, 2016 | 36 | 2016 |
| Apo-and antagonist-binding structures of vitamin D receptor ligand-binding domain revealed by hybrid approach combining small-angle X-ray scattering and molecular dynamics Y Anami, N Shimizu, T Ekimoto, D Egawa, T Itoh, M Ikeguchi, ... Journal of Medicinal Chemistry 59 (17), 7888-7900, 2016 | 35 | 2016 |
| Substitution at carbon 2 of 19-nor-1α, 25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells D Iglesias-Gato, S Zheng, JN Flanagan, L Jiang, A Kittaka, T Sakaki, ... The Journal of steroid biochemistry and molecular biology 127 (3-5), 269-275, 2011 | 35 | 2011 |
