Laura Heiser
Laura Heiser
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A community effort to assess and improve drug sensitivity prediction algorithms
JC Costello, LM Heiser, E Georgii, M Gönen, MP Menden, NJ Wang, ...
Nature biotechnology 32 (12), 1202-1212, 2014
Subtype and pathway specific responses to anticancer compounds in breast cancer
LM Heiser, A Sadanandam, WL Kuo, SC Benz, TC Goldstein, S Ng, ...
Proceedings of the National Academy of Sciences 109 (8), 2724-2729, 2012
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
OK Mirzoeva, D Das, LM Heiser, S Bhattacharya, D Siwak, R Gendelman, ...
Cancer research 69 (2), 565-572, 2009
The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ...
Cell systems 6 (1), 13-24, 2018
Metrics other than potency reveal systematic variation in responses to cancer drugs
M Fallahi-Sichani, S Honarnejad, LM Heiser, JW Gray, PK Sorger
Nature chemical biology 9 (11), 708, 2013
A central role for RAF→ MEK→ ERK signaling in the genesis of pancreatic ductal adenocarcinoma
EA Collisson, CL Trejo, JM Silva, S Gu, JE Korkola, LM Heiser, ...
Cancer discovery 2 (8), 685-693, 2012
How machine learning will transform biomedicine
J Goecks, V Jalili, LM Heiser, JW Gray
Cell 181 (1), 92-101, 2020
Modeling precision treatment of breast cancer
A Daemen, OL Griffith, LM Heiser, NJ Wang, OM Enache, Z Sanborn, ...
Genome biology 14 (10), R110, 2013
Tumor-derived Cell Lines as Molecular Models of Cancer Pharmacogenomics
A Goodspeed, LM Heiser, JW Gray, JC Costello
Molecular Cancer Research 14 (1), 3-13, 2016
A community computational challenge to predict the activity of pairs of compounds
M Bansal, J Yang, C Karan, MP Menden, JC Costello, H Tang, G Xiao, ...
Nature biotechnology 32 (12), 1213-1222, 2014
Inferring causal molecular networks: empirical assessment through a community-based effort
SM Hill, LM Heiser, T Cokelaer, M Unger, NK Nesser, DE Carlin, Y Zhang, ...
Nature methods 13 (4), 310-318, 2016
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
A Sehrawat, L Gao, Y Wang, A Bankhead, SK McWeeney, CJ King, ...
Proceedings of the National Academy of Sciences, 201719168, 2018
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
X Fu, R Jeselsohn, R Pereira, EF Hollingsworth, CJ Creighton, F Li, ...
Proceedings of the National Academy of Sciences, 201612835, 2016
Combating subclonal evolution of resistant cancer phenotypes
SW Brady, JA McQuerry, Y Qiao, SR Piccolo, G Shrestha, DF Jenkins, ...
Nature communications 8 (1), 1231, 2017
Bayesian inference of signaling network topology in a cancer cell line
SM Hill, Y Lu, J Molina, LM Heiser, PT Spellman, TP Speed, JW Gray, ...
Bioinformatics 28 (21), 2804-2810, 2012
Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with anti-HER2 therapy
M Giuliano, H Hu, YC Wang, X Fu, A Nardone, S Herrera, S Mao, ...
Clinical Cancer Research 21 (17), 3995-4003, 2015
A multi-center study on the reproducibility of drug-response assays in mammalian cell lines
M Niepel, M Hafner, CE Mills, K Subramanian, EH Williams, M Chung, ...
Cell systems 9 (1), 35-48. e5, 2019
HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer
X Xu, C De Angelis, KA Burke, A Nardone, H Hu, L Qin, J Veeraraghavan, ...
Clinical Cancer Research, clincanres. 2191.2016, 2017
Spatial updating in area LIP is independent of saccade direction
LM Heiser, CL Colby
Journal of neurophysiology 95 (5), 2751-2767, 2006
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance
AS Farrell, MM Joly, BL Allen-Petersen, PJ Worth, C Lanciault, D Sauer, ...
Nature Communications 8 (1), 1728, 2017
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