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Manikandan Periyasamy
Manikandan Periyasamy
Senior Research fellow
Dirección de correo verificada de imperial.ac.uk
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Año
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer
A Harrod, J Fulton, VTM Nguyen, M Periyasamy, L Ramos-Garcia, CF Lai, ...
Oncogene 36 (16), 2286-2296, 2017
1762017
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity
S Ali, DA Heathcote, SHB Kroll, AS Jogalekar, B Scheiper, H Patel, ...
Cancer research 69 (15), 6208-6215, 2009
1702009
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion
VTM Nguyen, I Barozzi, M Faronato, Y Lombardo, JH Steel, N Patel, ...
Nature communications 6 (1), 10044, 2015
1342015
miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts
L Pellegrino, J Stebbing, VM Braga, AE Frampton, J Jacob, L Buluwela, ...
Nucleic acids research 41 (10), 5400-5412, 2013
1342013
The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERα-positive breast cancer
NC Wortham, E Ahamed, SM Nicol, RS Thomas, M Periyasamy, J Jiang, ...
Oncogene 28 (46), 4053-4064, 2009
1342009
APOBEC3B-mediated cytidine deamination is required for estrogen receptor action in breast cancer
M Periyasamy, H Patel, CF Lai, VTM Nguyen, E Nevedomskaya, A Harrod, ...
Cell reports 13 (1), 108-121, 2015
1262015
ICEC0942, an orally bioavailable selective inhibitor of CDK7 for cancer treatment
H Patel, M Periyasamy, GP Sava, A Bondke, BW Slafer, SHB Kroll, ...
Molecular cancer therapeutics 17 (6), 1156-1166, 2018
1082018
A Novel Pyrazolo[1,5-a]pyrimidine Is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor …
DA Heathcote, H Patel, SHB Kroll, P Hazel, M Periyasamy, M Alikian, ...
Journal of medicinal chemistry 53 (24), 8508-8522, 2010
1052010
Expression of CDK7, cyclin H, and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor–positive breast cancer
H Patel, R Abduljabbar, CF Lai, M Periyasamy, A Harrod, C Gemma, ...
Clinical Cancer Research 22 (23), 5929-5938, 2016
922016
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
M Periyasamy, AK Singh, C Gemma, C Kranjec, R Farzan, DA Leach, ...
Nucleic acids research 45 (19), 11056-11069, 2017
862017
The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells
PTR Thiruchelvam, CF Lai, H Hua, RS Thomas, A Hurtado, W Hudson, ...
Breast cancer research and treatment 127, 385-396, 2011
812011
ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
J Lopez-Garcia, M Periyasamy, RS Thomas, M Christian, M Leao, P Jat, ...
Nucleic acids research 34 (21), 6126-6136, 2006
732006
Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo
Y Lombardo, A Filipović, G Molyneux, M Periyasamy, G Giamas, Y Hu, ...
Proceedings of the National Academy of Sciences 109 (41), 16558-16563, 2012
712012
LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner
HB Kramer, CF Lai, H Patel, M Periyasamy, ML Lin, SM Feller, ...
Nucleic acids research 44 (2), 582-594, 2016
572016
Low dose iron treatments induce a DNA damage response in human endothelial cells within minutes
IG Mollet, D Patel, FS Govani, A Giess, K Paschalaki, M Periyasamy, ...
PLoS One 11 (2), e0147990, 2016
562016
Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth
RS Tolhurst, RS Thomas, FJ Kyle, H Patel, M Periyasamy, A Photiou, ...
Breast cancer research and treatment 128, 357-368, 2011
402011
Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer
ML Lin, H Patel, J Remenyi, CRS Banerji, CF Lai, M Periyasamy, ...
Oncotarget 6 (25), 21685, 2015
302015
Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer
SC Baker, AS Mason, RG Slip, KT Skinner, A Macdonald, O Masood, ...
Oncogene 41 (15), 2139-2151, 2022
282022
Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB
M Periyasamy, AK Singh, C Gemma, R Farzan, RC Allsopp, JA Shaw, ...
Oncogene 40 (6), 1077-1090, 2021
252021
Endonuclease FEN1 Coregulates ERα activity and provides a novel drug Interface in Tamoxifen-resistant breast Cancer
KD Flach, M Periyasamy, A Jadhav, D Dorjsuren, JC Siefert, TE Hickey, ...
Cancer research 80 (10), 1914-1926, 2020
222020
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