Modelling Myc inhibition as a cancer therapy L Soucek, J Whitfield, CP Martins, AJ Finch, DJ Murphy, NM Sodir, ... Nature 455 (7213), 679-683, 2008 | 955 | 2008 |
Drugging the'undruggable'cancer targets CV Dang, EP Reddy, KM Shokat, L Soucek Nature Reviews Cancer 17 (8), 502-508, 2017 | 761 | 2017 |
Interrogating open issues in cancer precision medicine with patient-derived xenografts AT Byrne, DG Alférez, F Amant, D Annibali, J Arribas, AV Biankin, A Bruna, ... Nature Reviews Cancer 17 (4), 254-268, 2017 | 657 | 2017 |
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors L Soucek, ER Lawlor, D Soto, K Shchors, LB Swigart, GI Evan Nature medicine 13 (10), 1211-1218, 2007 | 580 | 2007 |
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology OM Pello, M De Pizzol, M Mirolo, L Soucek, L Zammataro, A Amabile, ... Blood, The Journal of the American Society of Hematology 119 (2), 411-421, 2012 | 373 | 2012 |
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice L Soucek, JR Whitfield, NM Sodir, D Massó-Vallés, E Serrano, ... Genes & development 27 (5), 504-513, 2013 | 350 | 2013 |
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead WH Goodson III, L Lowe, DO Carpenter, M Gilbertson, A Manaf Ali, ... Carcinogenesis 36 (Suppl_1), S254-S296, 2015 | 340 | 2015 |
Strategies to inhibit Myc and their clinical applicability JR Whitfield, ME Beaulieu, L Soucek Frontiers in cell and developmental biology 5, 10, 2017 | 311 | 2017 |
Design and properties of a Myc derivative that efficiently homodimerizes L Soucek, M Helmer-Citterich, A Sacco, R Jucker, G Cesareni, S Nasi Oncogene 17 (19), 2463-2472, 1998 | 237 | 1998 |
c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis S Kanazawa, L Soucek, G Evan, T Okamoto, BM Peterlin Oncogene 22 (36), 5707-5711, 2003 | 225 | 2003 |
Endogenous Myc maintains the tumor microenvironment NM Sodir, LB Swigart, AN Karnezis, D Hanahan, GI Evan, L Soucek Genes & development 25 (9), 907-916, 2011 | 221 | 2011 |
The ups and downs of Myc biology L Soucek, GI Evan Current opinion in genetics & development 20 (1), 91-95, 2010 | 216 | 2010 |
Temporal dissection of p53 function in vitro and in vivo MA Christophorou, D Martin-Zanca, L Soucek, ER Lawlor, ... Nature genetics 37 (7), 718-726, 2005 | 211 | 2005 |
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis D Annibali, JR Whitfield, E Favuzzi, T Jauset, E Serrano, I Cuartas, ... Nature communications 5 (1), 4632, 2014 | 207 | 2014 |
Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis L Soucek, R Jucker, L Panacchia, R Ricordy, F Tato, S Nasi Cancer research 62 (12), 3507-3510, 2002 | 203 | 2002 |
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy ME Beaulieu, T Jauset, D Massó-Vallés, S Martínez-Martín, P Rahl, ... Science translational medicine 11 (484), eaar5012, 2019 | 189 | 2019 |
Making decisions through Myc S Nasi, R Ciarapica, R Jucker, J Rosati, L Soucek FEBS letters 490 (3), 153-162, 2001 | 161 | 2001 |
MYC instructs and maintains pancreatic adenocarcinoma phenotype NM Sodir, RM Kortlever, VJA Barthet, T Campos, L Pellegrinet, S Kupczak, ... Cancer discovery 10 (4), 588-607, 2020 | 144 | 2020 |
The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy M Savino, D Annibali, N Carucci, E Favuzzi, MD Cole, GI Evan, L Soucek, ... PloS one 6 (7), e22284, 2011 | 144 | 2011 |
The effect of environmental chemicals on the tumor microenvironment SC Casey, M Vaccari, F Al-Mulla, R Al-Temaimi, A Amedei, ... Carcinogenesis 36 (Suppl_1), S160-S183, 2015 | 130 | 2015 |