Mariano J. Alvarez
Mariano J. Alvarez
Chief Scientific Officer, DarwinHealth Inc
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The transcriptional network for mesenchymal transformation of brain tumours
MS Carro, WK Lim, MJ Alvarez, RJ Bollo, X Zhao, EY Snyder, EP Sulman, ...
Nature 463 (7279), 318-325, 2009
Functional characterization of somatic mutations in cancer using network-based inference of protein activity
MJ Alvarez, Y Shen, FM Giorgi, A Lachmann, BB Ding, BH Ye, A Califano
Nature Genetics, 2016
Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: a potential mechanism of tumor-immune privilege
N Rubinstein, M Alvarez, NW Zwirner, MA Toscano, JM Ilarregui, A Bravo, ...
Cancer cell 5 (3), 241-251, 2004
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
C Lefebvre, P Rajbhandari, MJ Alvarez, P Bandaru, WK Lim, M Sato, ...
Molecular systems biology 6 (1), 2010
A community computational challenge to predict the activity of pairs of compounds
M Bansal, J Yang, C Karan, MP Menden, JC Costello, H Tang, G Xiao, ...
Nature Biotechnology, 2014
Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy
A Aytes, A Mitrofanova, C Lefebvre, MJ Alvarez, M Castillo-Martin, ...
Cancer cell 25 (5), 638-651, 2014
Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells
K Basso, M Saito, P Sumazin, AA Margolin, K Wang, WK Lim, Y Kitagawa, ...
Blood 115 (5), 975-984, 2010
Genome-wide identification of post-translational modulators of transcription factor activity in human B cells
K Wang, M Saito, BC Bisikirska, MJ Alvarez, WK Lim, P Rajbhandari, ...
Nature biotechnology 27 (9), 829-837, 2009
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state
GV Echeverria, Z Ge, S Seth, X Zhang, S Jeter-Jones, X Zhou, S Cai, Y Tu, ...
Science translational medicine 11 (488), 2019
Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks
JC Chen, MJ Alvarez, F Talos, H Dhruv, GE Rieckhof, A Iyer, KL Diefes, ...
Cell 159 (2), 402-414, 2014
The recurrent architecture of tumour initiation, progression and drug sensitivity
A Califano, MJ Alvarez
Nature Reviews Cancer, 2016
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors
MJ Alvarez, PS Subramaniam, LH Tang, A Grunn, M Aburi, G Rieckhof, ...
Nature genetics, 1, 2018
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
T Risom, EM Langer, MP Chapman, J Rantala, AJ Fields, C Boniface, ...
Nature communications 9 (1), 1-17, 2018
Identification of neurodegenerative factors using translatome-regulatory network analysis
L Brichta, W Shin, V Jackson-Lewis, J Blesa, EL Yap, Z Walker, J Zhang, ...
Nature neuroscience 18 (9), 1325-1333, 2015
PFT1, the MED25 subunit of the plant Mediator complex, promotes flowering through CONSTANS dependent and independent mechanisms in Arabidopsis
S Iñigo, MJ Alvarez, B Strasser, A Califano, PD Cerdán
The Plant Journal 69 (4), 601-612, 2012
Cross-cohort analysis identifies a TEAD4↔ MYCN positive-feedback loop as the core regulatory element of high-risk neuroblastoma
P Rajbhandari, G Lopez, C Capdevila, B Salvatori, J Yu, ...
Cancer Discovery, CD-16-0861, 2018
Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR−/HER2+ breast cancers
R Rodriguez-Barrueco, J Yu, LP Saucedo-Cuevas, M Olivan, ...
Genes & development 29 (15), 1631-1648, 2015
Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
H Ding, EF Douglass, AM Sonabend, A Mela, S Bose, C Gonzalez, ...
Nature communications 9 (1), 1-10, 2018
PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens
EC Bush, F Ray, MJ Alvarez, R Realubit, H Li, C Karan, A Califano, ...
Nature Communications 8 (1), 105, 2017
An integrated systems biology approach identifies TRIM25 as a key determinant of breast cancer metastasis
LA Walsh, MJ Alvarez, EY Sabio, M Reyngold, V Makarov, S Mukherjee, ...
Cell Reports 20 (7), 1623-1640, 2017
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
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