Attila Lehotzky
Attila Lehotzky
Institute of Enzymology, Research Centre of Natural Sciences
Dirección de correo verificada de ttk.hu
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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ...
Nature communications 6 (1), 1-13, 2015
1882015
Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)
M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ...
Journal of medicinal chemistry 61 (2), 482-491, 2018
1542018
Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies
GG Kovács, L László, J Kovács, PH Jensen, E Lindersson, G Botond, ...
Neurobiology of disease 17 (2), 155-162, 2004
1502004
Tubulin polymerization‐promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation
A Lehotzky, P Lau, N Tőkési, N Muja, LD Hudson, J Ovádi
Glia 58 (2), 157-168, 2010
1172010
Interaction of phosphofructokinase with tubulin and microtubules. Quantitative evaluation of the mutual effects
A Lehotzky, M Telegdi, K Liliom, J Ovadi
Journal of Biological Chemistry 268 (15), 10888-10894, 1993
991993
TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6
N Tőkési, A Lehotzky, I Horváth, B Szabó, J Oláh, P Lau, J Ovádi
Journal of Biological Chemistry 285 (23), 17896-17906, 2010
932010
Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions
O Vincze, N Tökési, J Oláh, E Hlavanda, Á Zotter, I Horváth, A Lehotzky, ...
Biochemistry 45 (46), 13818-13826, 2006
822006
The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases
GG Kovács, E Gelpi, A Lehotzky, R Höftberger, A Erdei, H Budka, J Ovádi
Acta neuropathologica 113 (2), 153-161, 2007
672007
TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments
F Orosz, GG Kovács, A Lehotzky, J Oláh, O Vincze, J Ovádi
Biology of the Cell 96 (9), 701-711, 2004
632004
Aminothiazoles as potent and selective Sirt2 inhibitors: a structure–activity relationship study
M Schiedel, T Rumpf, B Karaman, A Lehotzky, J Oláh, S Gerhardt, J Ovádi, ...
Journal of medicinal chemistry 59 (4), 1599-1612, 2016
572016
Structure‐Based Development of an Affinity Probe for Sirtuin 2
M Schiedel, T Rumpf, B Karaman, A Lehotzky, S Gerhardt, J Ovádi, ...
Angewandte Chemie International Edition 55 (6), 2252-2256, 2016
442016
Pyruvate Kinase as a Microtubule Destabilizing Factorin Vitro
BG Vértessy, D Bánkfalvi, J Kovács, P Löw, A Lehotzky, J Ovádi
Biochemical and biophysical research communications 254 (2), 430-435, 1999
411999
Interaction of TPPP/p25 protein with glyceraldehyde‐3‐phosphate dehydrogenase and their co‐localization in Lewy bodies
J Oláh, N Tőkési, O Vincze, I Horváth, A Lehotzky, A Erdei, E Szájli, ...
FEBS letters 580 (25), 5807-5814, 2006
382006
Characterization of microtubule− phosphofructokinase complex: specific effects of MgATP and vinblastine
BG Vértessy, J Kovács, P Löw, A Lehotzky, A Molnár, F Orosz, J Ovádi
Biochemistry 36 (8), 2051-2062, 1997
351997
TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells
M Preusser, A Lehotzky, H Budka, J Ovádi, GG Kovács
Acta neuropathologica 113 (2), 213-215, 2007
322007
Ligand-modulated cross-bridging of microtubules by phosphofructokinase
A Lehotzky, Z Palfia, J Kovacs, A Molnar, J Ovadi
Biochemical and biophysical research communications 204 (2), 585-591, 1994
301994
Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors
V Mangas‐Sanjuan, J Oláh, I Gonzalez‐Alvarez, A Lehotzky, N Tőkési, ...
British journal of pharmacology 172 (3), 829-840, 2015
222015
Characterization of tubulin-alkaloid interactions by enzyme-linked immunosorbent assay
K Liliom, A Lehotzky, A Molnar, J Ovadi
Analytical biochemistry 228 (1), 18-26, 1995
211995
Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25
N Tőkési, J Oláh, E Hlavanda, S Szunyogh, A Szabó, F Babos, A Magyar, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (4), 547-557, 2014
202014
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins
T Szénási, J Oláh, A Szabó, S Szunyogh, A Láng, A Perczel, A Lehotzky, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (1), 310-323, 2017
182017
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