Michael J. Gandal, MD/PhD
Michael J. Gandal, MD/PhD
William & Noreen Hetznecker Associate Professor of Psychiatry, University of Pennsylvania
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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
D Demontis, RK Walters, J Martin, M Mattheisen, TD Als, E Agerbo, ...
Nature genetics 51 (1), 63-75, 2019
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
V Trubetskoy, AF Pardiñas, T Qi, G Panagiotaropoulou, S Awasthi, ...
Nature 604 (7906), 502-508, 2022
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
MJ Gandal, P Zhang, E Hadjimichael, RL Walker, C Chen, S Liu, H Won, ...
Science 362 (6420), eaat8127, 2018
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa, G Ramaswami, C Hartl, ...
Science 359 (6376), 693-697, 2018
Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice
G Sharon, NJ Cruz, DW Kang, MJ Gandal, B Wang, YM Kim, EM Zink, ...
Cell 177 (6), 1600-1618. e17, 2019
Comprehensive functional genomic resource and integrative model for the human brain
D Wang, S Liu, J Warrell, H Won, X Shi, FCP Navarro, D Clarke, M Gu, ...
Science 362 (6420), eaat8464, 2018
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
N Mullins, AJ Forstner, KS O’Connell, B Coombes, JRI Coleman, Z Qiao, ...
Nature genetics 53 (6), 817-829, 2021
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
NN Parikshak, V Swarup, TG Belgard, M Irimia, G Ramaswami, ...
Nature 540 (7633), 423-427, 2016
Chromosome conformation elucidates regulatory relationships in developing human brain
H Won, L de La Torre-Ubieta, JL Stein, NN Parikshak, J Huang, ...
Nature 538 (7626), 523-527, 2016
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
NN Parikshak, MJ Gandal, DH Geschwind
Nature Reviews Genetics 16 (8), 441-458, 2015
Deletion of vanilloid receptor 1_expressing primary afferent neurons for pain control
L Karai, DC Brown, AJ Mannes, ST Connelly, J Brown, M Gandal, ...
The Journal of clinical investigation 113 (9), 1344-1352, 2004
Inherited and de novo genetic risk for autism impacts shared networks
EK Ruzzo, L Pérez-Cano, JY Jung, L Wang, D Kashef-Haghighi, C Hartl, ...
Cell 178 (4), 850-866. e26, 2019
Validating γ oscillations and delayed auditory responses as translational biomarkers of autism
MJ Gandal, JC Edgar, RS Ehrlichman, M Mehta, TPL Roberts, SJ Siegel
Biological psychiatry 68 (12), 1100-1106, 2010
MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism
TPL Roberts, SY Khan, M Rey, JF Monroe, K Cannon, L Blaskey, ...
Autism research 3 (1), 8-18, 2010
Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia
MJ Gandal, JC Edgar, K Klook, SJ Siegel
Neuropharmacology 62 (3), 1504-1518, 2012
The road to precision psychiatry: translating genetics into disease mechanisms
MJ Gandal, V Leppa, H Won, NN Parikshak, DH Geschwind
Nature neuroscience 19 (11), 1397-1407, 2016
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
T Singh, JTR Walters, M Johnstone, D Curtis, J Suvisaari, M Torniainen, ...
Nature genetics 49 (8), 1167-1173, 2017
Ketamine modulates theta and gamma oscillations
MT Lazarewicz, RS Ehrlichman, CR Maxwell, MJ Gandal, LH Finkel, ...
Journal of cognitive neuroscience 22 (7), 1452-1464, 2010
mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism
MV Mehta, MJ Gandal, SJ Siegel
PloS one 6 (10), e26077, 2011
Genetic control of expression and splicing in developing human brain informs disease mechanisms
RL Walker, G Ramaswami, C Hartl, N Mancuso, MJ Gandal, ...
Cell 179 (3), 750-771. e22, 2019
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