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Nobel O. Sierra-Vega, Ph.D.
Nobel O. Sierra-Vega, Ph.D.
PhD in Chemical Engineering
Dirección de correo verificada de upr.edu
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Assessment of blend uniformity in a continuous tablet manufacturing process
NO Sierra-Vega, A Román-Ospino, J Scicolone, FJ Muzzio, ...
International journal of pharmaceutics 560, 322-333, 2019
662019
In line monitoring of the powder flow behavior and drug content in a Fette 3090 feed frame at different operating conditions using Near Infrared spectroscopy
NO Sierra-Vega, A Sánchez-Paternina, N Maldonado, V Cárdenas, ...
Journal of Pharmaceutical and Biomedical Analysis 154, 384-396, 2018
362018
Feed frame: The last processing step before the tablet compaction in pharmaceutical manufacturing
NO Sierra-Vega, RJ Romañach, R Méndez
International journal of pharmaceutics 572, 118728, 2019
262019
Variographic analysis: a new methodology for quality assurance of pharmaceutical blending processes
A Sánchez-Paternina, NO Sierra-Vega, V Cárdenas, R Méndez, ...
Computers & Chemical Engineering 124, 109-123, 2019
232019
A sampling system for flowing powders based on the theory of sampling
BB Alvarado-Hernández, NO Sierra-Vega, P Martínez-Cartagena, ...
International Journal of Pharmaceutics 574, 118874, 2020
102020
Real-time quantification of low-dose cohesive formulations within a sampling interface for flowing powders
NO Sierra-Vega, RJ Romañach, R Méndez
International Journal of Pharmaceutics 588, 119726, 2020
92020
In-line monitoring of low drug concentration of flowing powders in a new sampler device
NO Sierra-Vega, PA Martínez-Cartagena, BB Alvarado-Hernández, ...
International Journal of Pharmaceutics 583, 119358, 2020
92020
Monitoring of high-load dose formulations based on co-processed and non co-processed excipients
NO Sierra-Vega, KM Karry, RJ Romanach, R Méndez
International journal of pharmaceutics 606, 120910, 2021
82021
An innovative sampling interface for monitoring flowing pharmaceutical powder mixtures
PA Martínez-Cartagena, NO Sierra-Vega, BB Alvarado-Hernández, ...
Journal of Pharmaceutical and Biomedical Analysis 194, 113785, 2021
32021
Assessment of blend uniformity in a stream sampler device using Raman spectroscopy
RS Rangel-Gil, NO Sierra-Vega, RJ Romañach, R Méndez
International Journal of Pharmaceutics 639, 122934, 2023
22023
Quantitative analysis of blend uniformity within a Three-Chamber feed frame using simultaneously Raman and Near-Infrared spectroscopy
NO Sierra-Vega, RA González-Rosario, RS Rangel-Gil, RJ Romañach, ...
International Journal of Pharmaceutics 613, 121417, 2022
22022
Design and pilot studies of TOS-compliant sampling interface for process analytical technology (PAT) analysis of pharmaceutical flowing powders mixtures
PA Martinez-Cartagena, BB Alvarado-Hernández, NO Sierra-Vega, ...
WCSB9-9th World Conference on Sampling and Blending. Beijing, China, 728-736, 2019
22019
Detection and quantification of corn starch and wheat flour as adulterants in milk powder by near-and mid-infrared spectroscopy coupled with chemometric routines
ER Caballero-Agosto, NO Sierra-Vega, Y Rolon-Ocasio, ...
Food Chemistry Advances 4, 100582, 2024
2024
Characterizing a design space for a twin-screw wet granulation process: A case study of extended-release tablets
NO Sierra-Vega, FM Alsharif, T O'Connor, M Ashraf, A Zidan
International Journal of Pharmaceutics 650, 123681, 2024
2024
The Use of a Closed Feed Frame for the Development of Near-Infrared Spectroscopic Calibration Model to Determine Drug Concentration
NA Movilla-Meza, NO Sierra-Vega, BB Alvarado-Hernández, R Méndez, ...
Pharmaceutical Research 40 (12), 2903-2916, 2023
2023
Differentiating Analytical Error from Sampling Errors in PAT Methods through Variographic Analysis
J Puchea, RJ Romañach, NS Vegab, R Méndezb
TOS forum, 2022
2022
Real-time monitoring of pharmaceutical formulations within continuous process units for tablet manufacturing
NO Sierra-Vega
2021
Development of an empirical model to predict the mean residence time in a tablet press feeder
NO Sierra-Vega
2017
Food Chemistry Advances
ER Caballero-Agosto, NO Sierra-Vega, Y Rolon-Ocasio, ...
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Artículos 1–19