Philip D. Kiser
Philip D. Kiser
University of California Irvine and VA Long Beach Healthcare System
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Chemistry of the retinoid (visual) cycle
PD Kiser, M Golczak, K Palczewski
Chemical reviews 114 (1), 194-232, 2014
Key enzymes of the retinoid (visual) cycle in vertebrate retina
PD Kiser, M Golczak, A Maeda, K Palczewski
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2012
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle
PD Kiser, M Golczak, DT Lodowski, MR Chance, K Palczewski
Proceedings of the National Academy of Sciences 106 (41), 17325-17330, 2009
The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
J von Lintig, PD Kiser, M Golczak, K Palczewski
Trends in biochemical sciences 35 (7), 400-410, 2010
Structural basis of carotenoid cleavage: from bacteria to mammals
X Sui, PD Kiser, J von Lintig, K Palczewski
Archives of biochemistry and biophysics 539 (2), 203-213, 2013
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina
M Golczak, A Maeda, G Bereta, T Maeda, PD Kiser, S Hunzelmann, ...
Journal of Biological Chemistry 283 (15), 9543-9554, 2008
Retinoids and retinal diseases
PD Kiser, K Palczewski
Annual review of vision science 2, 197-234, 2016
Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
S Gulati, H Jin, I Masuho, T Orban, Y Cai, E Pardon, KA Martemyanov, ...
Nature communications 9 (1), 1996, 2018
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing
S Suh, EH Choi, H Leinonen, AT Foik, GA Newby, WH Yeh, Z Dong, ...
Nature biomedical engineering 5 (2), 169-178, 2021
Structural basis for the acyltransferase activity of lecithin: retinol acyltransferase-like proteins
M Golczak, PD Kiser, AE Sears, DT Lodowski, WS Blaner, K Palczewski
Journal of Biological Chemistry 287 (28), 23790-23807, 2012
Catalytic mechanism of a retinoid isomerase essential for vertebrate vision
PD Kiser, J Zhang, M Badiee, Q Li, W Shi, X Sui, M Golczak, GP Tochtrop, ...
Nature chemical biology 11 (6), 409-415, 2015
Membrane-binding and enzymatic properties of RPE65
PD Kiser, K Palczewski
Progress in retinal and eye research 29 (5), 428-442, 2010
Molecular pharmacodynamics of emixustat in protection against retinal degeneration
J Zhang, PD Kiser, M Badiee, G Palczewska, Z Dong, M Golczak, ...
The Journal of clinical investigation 125 (7), 2781-2794, 2015
Characterization of the role of β-carotene 9, 10-dioxygenase in macular pigment metabolism
D Babino, G Palczewski, MAK Widjaja-Adhi, PD Kiser, M Golczak, ...
Journal of Biological Chemistry 290 (41), 24844-24857, 2015
Importance of membrane structural integrity for RPE65 retinoid isomerization activity
M Golczak, PD Kiser, DT Lodowski, A Maeda, K Palczewski
Journal of biological chemistry 285 (13), 9667-9682, 2010
Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis
PD Kiser, ER Farquhar, W Shi, X Sui, MR Chance, K Palczewski
Proceedings of the National Academy of Sciences 109 (41), E2747-E2756, 2012
Shedding new light on the generation of the visual chromophore
K Palczewski, PD Kiser
Proceedings of the National Academy of Sciences 117 (33), 19629-19638, 2020
Utilization of Dioxygen by Carotenoid Cleavage Oxygenases*♦
X Sui, M Golczak, J Zhang, KA Kleinberg, J von Lintig, K Palczewski, ...
Journal of Biological Chemistry 290 (51), 30212-30223, 2015
LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3
M Golczak, AE Sears, PD Kiser, K Palczewski
Nature chemical biology 11 (1), 26-32, 2015
The biochemical basis of vitamin A production from the asymmetric carotenoid β-cryptoxanthin
ME Kelly, S Ramkumar, W Sun, C Colon Ortiz, PD Kiser, M Golczak, ...
ACS chemical biology 13 (8), 2121-2129, 2018
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