Debra Josephs MBChB, PhD, MRCP
Debra Josephs MBChB, PhD, MRCP
Consultant Medical Oncologist
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Targeting folate receptor alpha for cancer treatment
A Cheung, HJ Bax, DH Josephs, KM Ilieva, G Pellizzari, J Opzoomer, ...
Oncotarget 7 (32), 52553, 2016
IgG4 subclass antibodies impair antitumor immunity in melanoma
P Karagiannis, AE Gilbert, DH Josephs, N Ali, T Dodev, L Saul, I Correa, ...
The Journal of clinical investigation 123 (4), 1457-1474, 2013
Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers
SA Harding, J Sarma, DH Josephs, NL Cruden, JN Din, PJ Twomey, ...
Circulation 109 (16), 1926-1929, 2004
Combining immune checkpoint inhibitors: established and emerging targets and strategies to improve outcomes in melanoma
DO Khair, HJ Bax, S Mele, S Crescioli, G Pellizzari, A Khiabany, ...
Frontiers in immunology 10, 453, 2019
Regional activation of myosin II in cancer cells drives tumor progression via a secretory cross-talk with the immune microenvironment
M Georgouli, C Herraiz, E Crosas-Molist, B Fanshawe, O Maiques, ...
Cell 176 (4), 757-774. e23, 2019
Clinical pharmacokinetics of tyrosine kinase inhibitors: implications for therapeutic drug monitoring
DH Josephs, DS Fisher, J Spicer, RJ Flanagan
Therapeutic drug monitoring 35 (5), 562-587, 2013
A tool kit for rapid cloning and expression of recombinant antibodies
TS Dodev, P Karagiannis, AE Gilbert, DH Josephs, H Bowen, LK James, ...
Scientific reports 4 (1), 1-10, 2014
Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)
RM Hoffmann, BGT Coumbe, DH Josephs, S Mele, KM Ilieva, A Cheung, ...
Oncoimmunology 7 (3), e1395127, 2018
Epidemiological associations of allergy, IgE and cancer
DH Josephs, JF Spicer, CJ Corrigan, HJ Gould, SN Karagiannis
Clinical & Experimental Allergy 43 (10), 1110-1123, 2013
Effects of BRAF Mutations and BRAF Inhibition on Immune Responses to MelanomaBRAF Mutations and Immunity in Melanoma
KM Ilieva, I Correa, DH Josephs, P Karagiannis, IU Egbuniwe, ...
Molecular cancer therapeutics 13 (12), 2769-2783, 2014
An automated method for the measurement of a range of tyrosine kinase inhibitors in human plasma or serum using turbulent flow liquid chromatography–tandem mass spectrometry
L Couchman, M Birch, R Ireland, A Corrigan, S Wickramasinghe, ...
Analytical and Bioanalytical Chemistry 403 (6), 1685-1695, 2012
BRAF inhibitors: resistance and the promise of combination treatments for melanoma
M Griffin, D Scotto, DH Josephs, S Mele, S Crescioli, HJ Bax, G Pellizzari, ...
Oncotarget 8 (44), 78174, 2017
Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies
AE Gilbert, P Karagiannis, T Dodev, A Koers, K Lacy, DH Josephs, ...
PloS one 6 (4), e19330, 2011
AllergoOncology–the impact of allergy in oncology: EAACI position paper
E Jensen‐Jarolim, HJ Bax, R Bianchini, M Capron, C Corrigan, M Castells, ...
Allergy 72 (6), 866-887, 2017
Tumour-associated macrophage polarisation and re-education with immunotherapy
DH Josephs, HJ Bax, SN Karagiannis
Front Biosci (Elite Ed) 7, 293-308, 2015
Molecular imaging in clinical trials
D Josephs, J Spicer, M O’Doherty
Targeted oncology 4 (3), 151-168, 2009
Efficacy and toxicity of sunitinib in patients with metastatic renal cell carcinoma with severe renal impairment or on haemodialysis
D Josephs, TE Hutson, CL Cowey, LM Pickering, JM Larkin, ME Gore, ...
BJU international 108 (8), 1279-1283, 2011
Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application
SN Karagiannis, DH Josephs, P Karagiannis, AE Gilbert, L Saul, ...
Cancer Immunology, Immunotherapy 61 (9), 1547-1564, 2012
Factors affecting COVID-19 outcomes in cancer patients: a first report from guy's cancer center in London
B Russell, C Moss, S Papa, S Irshad, P Ross, J Spicer, S Kordasti, ...
Frontiers in oncology 10, 1279, 2020
Anti-folate receptor alpha–directed antibody therapies restrict the growth of triple-negative breast cancer
A Cheung, J Opzoomer, KM Ilieva, P Gazinska, RM Hoffmann, H Mirza, ...
Clinical Cancer Research 24 (20), 5098-5111, 2018
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