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Dennis Selkoe
Dennis Selkoe
Co-Director, Ann Romney Center for Neurologic Disases, Brigham and Women's Hospital
Verified email at bwh.harvard.edu
Title
Cited by
Cited by
Year
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
J Hardy, DJ Selkoe
science 297 (5580), 353-356, 2002
167912002
Alzheimer's disease: genes, proteins, and therapy
DJ Selkoe
Physiological reviews, 2001
80792001
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
C Haass, DJ Selkoe
Nature reviews Molecular cell biology 8 (2), 101-112, 2007
58932007
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
DM Walsh, I Klyubin, JV Fadeeva, WK Cullen, R Anwyl, MS Wolfe, ...
Nature 416 (6880), 535-539, 2002
55122002
The amyloid hypothesis of Alzheimer's disease at 25 years
DJ Selkoe, J Hardy
EMBO molecular medicine 8 (6), 595-608, 2016
53942016
Alzheimer's disease is a synaptic failure
DJ Selkoe
Science 298 (5594), 789-791, 2002
51692002
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
GM Shankar, S Li, TH Mehta, A Garcia-Munoz, NE Shepardson, I Smith, ...
Nature medicine 14 (8), 837-842, 2008
44112008
The molecular pathology of Alzheimer's disease
DJ Selkoe
Neuron 6 (4), 487-498, 1991
36731991
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to …
D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ...
Nature medicine 2 (8), 864-870, 1996
35601996
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
B Dubois, HH Feldman, C Jacova, H Hampel, JL Molinuevo, K Blennow, ...
The Lancet Neurology 13 (6), 614-629, 2014
35342014
Amyloid β-peptide is produced by cultured cells during normal metabolism
C Haass, MG Schlossmacher, AY Hung, C Vigo-Pelfrey, A Mellon, ...
Nature 359 (6393), 322-325, 1992
26991992
Complement and microglia mediate early synapse loss in Alzheimer mouse models
S Hong, VF Beja-Glasser, BM Nfonoyim, A Frouin, S Li, S Ramakrishnan, ...
Science 352 (6286), 712-716, 2016
26102016
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
M Citron, T Oltersdorf, C Haass, L McConlogue, AY Hung, P Seubert, ...
Nature 360 (6405), 672-674, 1992
26011992
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
MS Wolfe, W Xia, BL Ostaszewski, TS Diehl, WT Kimberly, DJ Selkoe
Nature 398 (6727), 513-517, 1999
25821999
Aβ oligomers–a decade of discovery
DM Walsh, DJ Selkoe
Journal of neurochemistry 101 (5), 1172-1184, 2007
25322007
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
P Seubert, C Vigo-Pelfrey, F Esch, M Lee, H Dovey, D Davis, S Sinha, ...
Nature 359 (6393), 325-327, 1992
23641992
Translating cell biology into therapeutic advances in Alzheimer's disease
DJ Selkoe
Nature 399 (6738), A23-A31, 1999
23061999
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
JP Cleary, DM Walsh, JJ Hofmeister, GM Shankar, MA Kuskowski, ...
Nature neuroscience 8 (1), 79-84, 2005
22182005
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
GM Shankar, BL Bloodgood, M Townsend, DM Walsh, DJ Selkoe, ...
Journal of Neuroscience 27 (11), 2866-2875, 2007
20242007
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.
KS KoSIK, CL Joachim, DJ Selkoe
Proceedings of the National Academy of Sciences 83 (11), 4044-4048, 1986
18811986
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