DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity C Lu, J Guan, S Lu, Q Jin, B Rousseau, T Lu, D Stephens, H Zhang, J Zhu, ... Cancer cell 39 (1), 96-108. e6, 2021 | 177 | 2021 |
MLH1 deficiency-triggered DNA hyperexcision by exonuclease 1 activates the cGAS-STING pathway J Guan, C Lu, Q Jin, H Lu, X Chen, L Tian, Y Zhang, J Ortega, J Zhang, ... Cancer cell 39 (1), 109-121. e5, 2021 | 129 | 2021 |
RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair T Li, J Guan, Z Huang, X Hu, X Zheng Journal of cell science 127 (10), 2238-2248, 2014 | 75 | 2014 |
hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14 J Zhang, D Bai, X Ma, J Guan, X Zheng Oncogene 33 (2), 246-254, 2014 | 58 | 2014 |
HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination T Li, J Guan, S Li, X Zhang, X Zheng Cell death & disease 5 (5), e1229-e1229, 2014 | 35 | 2014 |
NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage J Guan, S Yu, X Zheng Protein & cell 9 (4), 365-379, 2018 | 28 | 2018 |
MyD88 NEDDylation negatively regulates MyD88-dependent NF-κB signaling through antagonizing its ubiquitination F Yan, J Guan, Y Peng, X Zheng Biochemical and biophysical research communications 482 (4), 632-637, 2017 | 17 | 2017 |
Targeting UBE2T potentiates gemcitabine efficacy in pancreatic cancer by regulating pyrimidine metabolism and replication stress X Jiang, Y Ma, T Wang, H Zhou, K Wang, W Shi, L Qin, J Guan, L Li, ... Gastroenterology 164 (7), 1232-1247, 2023 | 13 | 2023 |
The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen X Dong, J Guan, C Zheng, X Zheng Journal of Biological Chemistry 292 (20), 8472-8483, 2017 | 13 | 2017 |
A CRM 1‐Dependent Nuclear Export Signal Controls Nucleocytoplasmic Translocation of HSCARG, Which Regulates NF‐κB Activity M Zhang, B Hu, T Li, Y Peng, J Guan, S Lai, X Zheng Traffic 13 (6), 790-799, 2012 | 13 | 2012 |
NEDDylation regulates RAD18 ubiquitination and localization in response to oxidative DNA damage J Guan, X Zheng Biochemical and biophysical research communications 508 (4), 1240-1244, 2019 | 9 | 2019 |
DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks H Lu, J Guan, SY Wang, GM Li, VA Bohr, AJ Davis Nucleic acids research 50 (10), 5635-5651, 2022 | 7 | 2022 |
DNA mismatch repair in cancer immunotherapy J Guan, GM Li NAR cancer 5 (3), zcad031, 2023 | 6 | 2023 |
PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer H Ye, W Shi, J Yang, L Wang, X Jiang, H Zhao, L Qin, J Qin, L Li, W Cai, ... Cancer Research 83 (22), 3767-3782, 2023 | 3 | 2023 |
Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS–STING-dependent apoptosis X Sun, L Liu, C Wu, X Li, J Guo, J Zhang, J Guan, N Wang, L Gu, ... Proceedings of the National Academy of Sciences 121 (13), e2313652121, 2024 | | 2024 |
RNF168-mediated H2A neddylation antagonizes its ubiquitinationand regulates DNA damage repair J Guan, T Li, X Zheng 中国生物化学与分子生物学会第十一次会员代表大会暨 2014 年全国学术会议论文集 …, 2014 | | 2014 |
Critical Reviews and Perspectives DNA mismatch repair in cancer immunotherapy J Guan, GM Li | | |