Seguir
David B. Sykes
David B. Sykes
Massachusetts General Hospital
Dirección de correo verificada de mgh.harvard.edu - Página principal
Título
Citado por
Citado por
Año
Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia
DB Sykes, YS Kfoury, FE Mercier, MJ Wawer, JM Law, MK Haynes, ...
Cell 167 (1), 171-186. e15, 2016
4412016
Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
GG Wang, KR Calvo, MP Pasillas, DB Sykes, H Häcker, MP Kamps
Nature methods 3 (4), 287-293, 2006
4072006
TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism
JS Welch, L Escoubet-Lozach, DB Sykes, K Liddiard, DR Greaves, ...
Journal of Biological Chemistry 277 (45), 42821-42829, 2002
3172002
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
P Simic, K Zainabadi, E Bell, DB Sykes, B Saez, S Lotinun, R Baron, ...
EMBO molecular medicine 5 (3), 430-440, 2013
2542013
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin
R Palchaudhuri, B Saez, J Hoggatt, A Schajnovitz, DB Sykes, TA Tate, ...
Nature biotechnology 34 (7), 738-745, 2016
2252016
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
KW Yoon, S Byun, E Kwon, SY Hwang, K Chu, M Hiraki, SH Jo, A Weins, ...
Science 349 (6247), 1261669, 2015
2212015
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
S Christian, C Merz, L Evans, S Gradl, H Seidel, A Friberg, A Eheim, ...
Leukemia 33 (10), 2403-2415, 2019
1692019
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease
E Hahm, C Wei, I Fernandez, J Li, NJ Tardi, M Tracy, S Wadhwani, Y Cao, ...
Nature medicine 23 (1), 100-106, 2017
1542017
Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent …
KR Calvo, DB Sykes, M Pasillas, MP Kamps
Molecular and cellular biology 20 (9), 3274-3285, 2000
1512000
Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by …
KR Calvo, DB Sykes, MP Pasillas, MP Kamps
Oncogene 21 (27), 4247-4256, 2002
1462002
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation
GW Klappacher, VV Lunyak, DB Sykes, D Sawka-Verhelle, J Sage, ...
Cell 109 (2), 169-180, 2002
1272002
Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia
KR Calvo, PS Knoepfler, DB Sykes, MP Pasillas, MP Kamps
Proceedings of the National Academy of Sciences 98 (23), 13120-13125, 2001
1212001
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment
Y Kfoury, N Baryawno, N Severe, S Mei, K Gustafsson, T Hirz, T Brouse, ...
Cancer cell 39 (11), 1464-1478. e8, 2021
1132021
Induction of a timed metabolic collapse to overcome cancer chemoresistance
N Van Gastel, JB Spinelli, A Sharda, A Schajnovitz, N Baryawno, C Rhee, ...
Cell Metabolism 32 (3), 391-403. e6, 2020
1012020
The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia
DB Sykes
Expert opinion on therapeutic targets 22 (11), 893-898, 2018
982018
The hematopoietic stem cell niche
D Park, DB Sykes, DT Scadden
Frontiers in bioscience (Landmark edition) 17, 30, 2012
942012
The TEMPI syndrome—a novel multisystem disease
DB Sykes, W Schroyens, C O'Connell
New England Journal of Medicine 365 (5), 475-477, 2011
922011
Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney
P Simic, W Kim, W Zhou, KA Pierce, W Chang, DB Sykes, NB Aziz, ...
The Journal of clinical investigation 130 (3), 1513-1526, 2020
892020
Dectin-1 activation controls maturation of β-1, 3-glucan-containing phagosomes
MK Mansour, JM Tam, NS Khan, M Seward, PJ Davids, S Puranam, ...
Journal of Biological Chemistry 288 (22), 16043-16054, 2013
852013
HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation
PS Knoepfler, DB Sykes, M Pasillas, MP Kamps
Oncogene 20 (39), 5440-5448, 2001
802001
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
Artículos 1–20