David B. Sykes
David B. Sykes
Massachusetts General Hospital
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Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia
DB Sykes, YS Kfoury, FE Mercier, MJ Wawer, JM Law, MK Haynes, ...
Cell 167 (1), 171-186. e15, 2016
Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
GG Wang, KR Calvo, MP Pasillas, DB Sykes, H Häcker, MP Kamps
Nature methods 3 (4), 287-293, 2006
TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism
JS Welch, L Escoubet-Lozach, DB Sykes, K Liddiard, DR Greaves, ...
Journal of Biological Chemistry 277 (45), 42821-42829, 2002
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
P Simic, K Zainabadi, E Bell, DB Sykes, B Saez, S Lotinun, R Baron, ...
EMBO molecular medicine 5 (3), 430-440, 2013
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin
R Palchaudhuri, B Saez, J Hoggatt, A Schajnovitz, DB Sykes, TA Tate, ...
Nature biotechnology 34 (7), 738-745, 2016
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
KW Yoon, S Byun, E Kwon, SY Hwang, K Chu, M Hiraki, SH Jo, A Weins, ...
Science 349 (6247), 1261669, 2015
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
S Christian, C Merz, L Evans, S Gradl, H Seidel, A Friberg, A Eheim, ...
Leukemia 33 (10), 2403-2415, 2019
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease
E Hahm, C Wei, I Fernandez, J Li, NJ Tardi, M Tracy, S Wadhwani, Y Cao, ...
Nature medicine 23 (1), 100-106, 2017
Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent …
KR Calvo, DB Sykes, M Pasillas, MP Kamps
Molecular and cellular biology 20 (9), 3274-3285, 2000
Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by …
KR Calvo, DB Sykes, MP Pasillas, MP Kamps
Oncogene 21 (27), 4247-4256, 2002
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation
GW Klappacher, VV Lunyak, DB Sykes, D Sawka-Verhelle, J Sage, ...
Cell 109 (2), 169-180, 2002
Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia
KR Calvo, PS Knoepfler, DB Sykes, MP Pasillas, MP Kamps
Proceedings of the National Academy of Sciences 98 (23), 13120-13125, 2001
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment
Y Kfoury, N Baryawno, N Severe, S Mei, K Gustafsson, T Hirz, T Brouse, ...
Cancer cell 39 (11), 1464-1478. e8, 2021
Induction of a timed metabolic collapse to overcome cancer chemoresistance
N Van Gastel, JB Spinelli, A Sharda, A Schajnovitz, N Baryawno, C Rhee, ...
Cell Metabolism 32 (3), 391-403. e6, 2020
The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia
DB Sykes
Expert opinion on therapeutic targets 22 (11), 893-898, 2018
The hematopoietic stem cell niche
D Park, DB Sykes, DT Scadden
Frontiers in bioscience (Landmark edition) 17, 30, 2012
The TEMPI syndrome—a novel multisystem disease
DB Sykes, W Schroyens, C O'Connell
New England Journal of Medicine 365 (5), 475-477, 2011
Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney
P Simic, W Kim, W Zhou, KA Pierce, W Chang, DB Sykes, NB Aziz, ...
The Journal of clinical investigation 130 (3), 1513-1526, 2020
Dectin-1 activation controls maturation of β-1, 3-glucan-containing phagosomes
MK Mansour, JM Tam, NS Khan, M Seward, PJ Davids, S Puranam, ...
Journal of Biological Chemistry 288 (22), 16043-16054, 2013
HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation
PS Knoepfler, DB Sykes, M Pasillas, MP Kamps
Oncogene 20 (39), 5440-5448, 2001
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Artículos 1–20