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Andrés D. Román
Andrés D. Román
Associate Principal Scientist at Merck
Dirección de correo verificada de merck.com
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Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process
R Singh, AD Román-Ospino, RJ Romañach, M Ierapetritou, ...
International journal of pharmaceutics 495 (1), 612-625, 2015
792015
Effect of tracer material properties on the residence time distribution (RTD) of continuous powder blending operations. Part I of II: Experimental evaluation
MS Escotet-Espinoza, S Moghtadernejad, S Oka, Y Wang, ...
Powder technology 342, 744-763, 2019
732019
Assessment of blend uniformity in a continuous tablet manufacturing process
NO Sierra-Vega, A Román-Ospino, J Scicolone, FJ Muzzio, ...
International journal of pharmaceutics 560, 322-333, 2019
662019
Near infrared spectroscopic calibration models for real time monitoring of powder density
AD Román-Ospino, R Singh, M Ierapetritou, R Ramachandran, R Méndez, ...
International journal of pharmaceutics 512 (1), 61-74, 2016
582016
Adequacy and verifiability of pharmaceutical mixtures and dose units by variographic analysis (Theory of Sampling)–A call for a regulatory paradigm shift
KH Esbensen, AD Román-Ospino, A Sanchez, RJ Romañach
International journal of pharmaceutics 499 (1-2), 156-174, 2016
572016
Effect of material properties on the residence time distribution (RTD) characterization of powder blending unit operations. Part II of II: Application of models
MS Escotet-Espinoza, S Moghtadernejad, S Oka, Z Wang, Y Wang, ...
Powder technology 344, 525-544, 2019
462019
Advanced process design and understanding of continuous twin-screw granulation via implementation of in-line process analytical technologies
W Meng, AD Román-Ospino, SS Panikar, C O'Callaghan, SJ Gilliam, ...
Advanced Powder Technology 30 (4), 879-894, 2019
432019
Evaluation of analytical and sampling errors in the prediction of the active pharmaceutical ingredient concentration in blends from a continuous manufacturing process
JM Vargas, AD Roman-Ospino, E Sanchez, RJ Romañach
Journal of Pharmaceutical Innovation 12, 155-167, 2017
392017
A training on: continuous manufacturing (direct compaction) of solid dose pharmaceutical products
S Moghtadernejad, MS Escotet-Espinoza, S Oka, R Singh, Z Liu, ...
Journal of pharmaceutical innovation 13, 155-187, 2018
352018
Development of near infrared spectroscopic calibration models for in-line determination of low drug concentration, bulk density, and relative specific void volume within a feed …
C Ortega-Zúñiga, C Pinzón-De la Rosa, AD Román-Ospino, ...
Journal of pharmaceutical and biomedical analysis 164, 211-222, 2019
322019
Applications of quantum cascade laser spectroscopy in the analysis of pharmaceutical formulations
NJ Galán-Freyle, LC Pacheco-Londoño, AD Román-Ospino, ...
Applied spectroscopy 70 (9), 1511-1519, 2016
262016
Prediction of dissolution profiles by non-destructive NIR spectroscopy in bilayer tablets
Y Baranwal, AD Román-Ospino, G Keyvan, JM Ha, EP Hong, FJ Muzzio, ...
International Journal of Pharmaceutics 565, 419-436, 2019
232019
Near infrared spectroscopic transmittance measurements for pharmaceutical powder mixtures
A Sánchez-Paternina, AD Román-Ospino, M Martínez, J Mercado, ...
Journal of pharmaceutical and biomedical analysis 123, 120-127, 2016
232016
Combined feedforward/feedback control of an integrated continuous granulation process
GC Pereira, SV Muddu, AD Román-Ospino, D Clancy, B Igne, C Airiau, ...
Journal of Pharmaceutical Innovation 14, 259-285, 2019
192019
Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones
S Tanimura, R Singh, AD Román-Ospino, M Ierapetritou
International Journal of Pharmaceutics 592, 120048, 2021
182021
Sampling optimization for blend monitoring of a low dose formulation in a tablet press feed frame using spatially resolved near-infrared spectroscopy
AD Román-Ospino, Y Baranwal, J Li, J Vargas, B Igne, S Bate, ...
International Journal of Pharmaceutics 602, 120594, 2021
172021
A procedure for developing quantitative near infrared (NIR) methods for pharmaceutical products
RJ Romañach, AD Román-Ospino, M Alcalà
Process Simulation and Data Modeling in Solid Oral Drug Development and …, 2016
152016
Characterization of NIR interfaces for the feeding and in-line monitoring of a continuous granulation process
AD Román-Ospino, A Tamrakar, B Igne, ET Dimaso, C Airiau, DJ Clancy, ...
International Journal of Pharmaceutics 574, 118848, 2020
142020
Classical least squares-assisted mid-infrared (MIR) laser spectroscopy detection of high explosives on fabrics
LC Pacheco-Londoño, JA Aparicio-Bolaño, NJ Galán-Freyle, ...
Applied Spectroscopy 73 (1), 17-29, 2019
142019
Theory of Sampling (TOS): a necessary and sufficient guarantee for reliable multivariate data analysis in pharmaceutical manufacturing
KH Esbensen, RJ Romañach, AD Román-Ospino
Multivariate Analysis in the Pharmaceutical Industry, 53-91, 2018
142018
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