Ulrich Brinkmann
Ulrich Brinkmann
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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
S Hoffmeyer, O Burk, O Von Richter, HP Arnold, J Brockmöller, A Johne, ...
Proceedings of the National Academy of Sciences 97 (7), 3473-3478, 2000
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects*
I Cascorbi, T Gerloff, A Johne, C Meisel, S Hoffmeyer, M Schwab, ...
Clinical Pharmacology & Therapeutics 69 (3), 169-174, 2001
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
A Siddiqui, R Kerb, ME Weale, U Brinkmann, A Smith, DB Goldstein, ...
New England Journal of Medicine 348 (15), 1442-1448, 2003
High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product
U Brinkmann, RE Mattes, P Buckel
Gene 85 (1), 109-114, 1989
A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies
J Buchner, I Pastan, U Brinkmann
Analytical biochemistry 205 (2), 263-270, 1992
Bispecific antibodies
RE Kontermann, U Brinkmann
Drug discovery today 20 (7), 838-847, 2015
The making of bispecific antibodies
U Brinkmann, RE Kontermann
MAbs 9 (2), 182-212, 2017
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
M Schwab, E Schaeffeler, C Marx, MF Fromm, B Kaskas, J Metzler, ...
Gastroenterology 124 (1), 26-33, 2003
Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene*
A Johne, K Köpke, T Gerloff, I Mai, S Rietbrock, C Meisel, S Hoffmeyer, ...
Clinical Pharmacology & Therapeutics 72 (5), 584-594, 2002
Frequency of C3435T polymorphism of MDR1 gene in African people
E Schaeffeler, M Eichelbaum, U Brinkmann, A Penger, S Asante-Poku, ...
The Lancet 358 (9279), 383-384, 2001
Association of the P-glycoprotein transporter MDR1C3435T polymorphism with the susceptibility to renal epithelial tumors
M Siegsmund, U Brinkmann, E Scháffeler, G Weirich, M Schwab, ...
Journal of the American Society of Nephrology 13 (7), 1847-1854, 2002
MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine
S Drescher, E Schaeffeler, M Hitzl, U Hofmann, M Schwab, U Brinkmann, ...
British journal of clinical pharmacology 53 (5), 526-534, 2002
A recombinant immunotoxin containing a disulfide-stabilized Fv fragment
U Brinkmann, Y Reiter, SH Jung, B Lee, I Pastan
Proceedings of the National Academy of Sciences 90 (16), 7538-7542, 1993
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene
K Gellner, R Eiselt, E Hustert, H Arnold, I Koch, M Haberl, CJ Deglmann, ...
Pharmacogenetics and Genomics 11 (2), 111-121, 2001
B3 (Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice
U Brinkmann, LEEH PAi, DJ FitzGerald, M Willingham, I Pastan
Proceedings of the National Academy of Sciences 88 (19), 8616-8620, 1991
Engineering antibody Fv fragments for cancer detection and therapy: bisulfide-stabilized Fv fragments
Y Reiter, U Brinkmann, B Lee, I Pastan
Nature biotechnology 14 (10), 1239-1245, 1996
Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4
E Hustert, A Zibat, E Presecan-Siedel, R Eiselt, R Mueller, C Fuß, I Brehm, ...
Drug metabolism and disposition 29 (11), 1454-1459, 2001
ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2
R Kerb, S Hoffmeyer, U Brinkmann
Pharmacogenomics 2 (1), 51-64, 2001
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences
R Kerb, U Brinkmann, N Chatskaia, D Gorbunov, V Gorboulev, ...
Pharmacogenetics and Genomics 12 (8), 591-595, 2002
Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3
R Hoess, U Brinkmann, T Handel, I Pastan
Gene 128 (1), 43-49, 1993
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Artículos 1–20