James Inglese
James Inglese
ADST Laboratory, NCATS, Adjunct Investigator NHGRI, NIH
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Role of βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors
JA Pitcher, J Inglese, JB Higgins, JL Arriza, PJ Casey, C Kim, JL Benovic, ...
Science 257 (5074), 1264-1267, 1992
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine
RA Seder, LJ Chang, ME Enama, KL Zephir, UN Sarwar, IJ Gordon, ...
Science 341 (6152), 1359-1365, 2013
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries
J Inglese, DS Auld, A Jadhav, RL Johnson, A Simeonov, A Yasgar, ...
Proceedings of the National Academy of Sciences 103 (31), 11473-11478, 2006
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
High-throughput screening assays for the identification of chemical probes
J Inglese, RL Johnson, A Simeonov, M Xia, W Zheng, CP Austin, DS Auld
Nature chemical biology 3 (8), 466-479, 2007
Protein kinases that phosphorylate activated G protein‐coupled receptors
RT Premont, J Inglese, RJ Lefkowitz
The FASEB Journal 9 (2), 175-182, 1995
Binding of G protein beta gamma-subunits to pleckstrin homology domains.
K Touhara, J Inglese, JA Pitcher, G Shaw, RJ Lefkowitz
Journal of Biological Chemistry 269 (14), 10217-10220, 1994
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
E Reuveny, PA Slesinger, J Inglese, JM Morales, JA Iñiguez-Lluhi, ...
Nature 370 (6485), 143-146, 1994
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
WJ Koch, J Inglese, WC Stone, RJ Lefkowitz
Journal of Biological Chemistry 268 (11), 8256-8260, 1993
Structure and mechanism of the G protein-coupled receptor kinases.
J Inglese, NJ Freedman, WJ Koch, RJ Lefkowitz
The Journal of biological chemistry 268 (32), 23735-23738, 1993
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
WJ Koch, BE Hawes, J Inglese, LM Luttrell, RJ Lefkowitz
Journal of Biological Chemistry 269 (8), 6193-6197, 1994
Apparent activity in high-throughput screening: origins of compound-dependent assay interference
N Thorne, DS Auld, J Inglese
Current opinion in chemical biology 14 (3), 315-324, 2010
A high-throughput screen for aggregation-based inhibition in a large compound library
BY Feng, A Simeonov, A Jadhav, K Babaoglu, J Inglese, BK Shoichet, ...
Journal of medicinal chemistry 50 (10), 2385-2390, 2007
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
J Inglese, WJ Koch, MG Caron, RJ Lefkowitz
Nature 359 (6391), 147-150, 1992
Ca2+-dependent interaction of recoverin with rhodopsin kinase
CK Chen, J Inglese, RJ Lefkowitz, JB Hurley
Journal of Biological Chemistry 270 (30), 18060-18066, 1995
Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology
N Thorne, J Inglese, DS Auld
Chemistry & biology 17 (6), 646-657, 2010
A region of adenylyl cyclase 2 critical for regulation by G protein βγ subunits
J Chen, M DeVivo, J Dingus, A Harry, J Li, J Sui, DJ Carty, JL Blank, ...
Science 268 (5214), 1166-1169, 1995
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
AA Sayed, A Simeonov, CJ Thomas, J Inglese, CP Austin, DL Williams
Nature medicine 14 (4), 407-412, 2008
Compound cytotoxicity profiling using quantitative high-throughput screening
M Xia, R Huang, KL Witt, N Southall, J Fostel, MH Cho, A Jadhav, ...
Environmental health perspectives 116 (3), 284-291, 2008
Fluorescence spectroscopic profiling of compound libraries
A Simeonov, A Jadhav, CJ Thomas, Y Wang, R Huang, NT Southall, ...
Journal of medicinal chemistry 51 (8), 2363-2371, 2008
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