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Laurie Schenkel
Laurie Schenkel
Medicinal Chemistry, Amgen
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New air-stable catalysts for general and efficient Suzuki− Miyaura cross-coupling reactions of heteroaryl chlorides
AS Guram, AO King, JG Allen, X Wang, LB Schenkel, J Chan, EE Bunel, ...
Organic letters 8 (9), 1787-1789, 2006
2032006
Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines
M Payton, TL Bush, G Chung, B Ziegler, P Eden, P McElroy, S Ross, ...
Cancer research 70 (23), 9846-9854, 2010
1392010
Novel sulfinyl imine ligands for asymmetric catalysis
LB Schenkel, JA Ellman
Organic Letters 5 (4), 545-548, 2003
1042003
Synthesis and Resolution of a Novel Chiral Diamine Ligand and Application to Asymmetric Lithiation− Substitution
X Li, LB Schenkel, MC Kozlowski
Organic Letters 2 (7), 875-878, 2000
892000
Self-Condensation of N-tert-Butanesulfinyl Aldimines:  Application to the Rapid Asymmetric Synthesis of Biologically Important Amine-Containing Compounds
LB Schenkel, JA Ellman
Organic Letters 6 (20), 3621-3624, 2004
872004
Application of P,N-Sulfinyl Imine Ligands to Iridium-Catalyzed Asymmetric Hydrogenation of Olefins
LB Schenkel, JA Ellman
The Journal of Organic Chemistry 69 (6), 1800-1802, 2004
842004
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that …
RF Graceffa, AA Boezio, J Able, S Altmann, LM Berry, C Boezio, JR Butler, ...
Journal of medicinal chemistry 60 (14), 5990-6017, 2017
632017
Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity
LB Schenkel, PR Olivieri, AA Boezio, HL Deak, R Emkey, RF Graceffa, ...
Journal of medicinal chemistry 59 (6), 2794-2809, 2016
592016
PI3 kinase modulators and methods of use
S Booker, N D'angelo, DC D'amico, TS Kim, L Liu, K Meagher, ...
US Patent App. 12/221,416, 2009
542009
Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors
LB Schenkel, X Huang, A Cheng, HL Deak, E Doherty, R Emkey, Y Gu, ...
Journal of medicinal chemistry 54 (24), 8440-8450, 2011
512011
Aurora kinase modulators and method of use
VJ Cee, HN Nguyen, K Romero
US Patent 7,560,551, 2009
492009
Discovery of N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally …
S Geuns-Meyer, VJ Cee, HL Deak, B Du, BL Hodous, HN Nguyen, ...
Journal of Medicinal Chemistry 58 (13), 5189-5207, 2015
432015
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine Aurora kinase inhibitor
VJ Cee, LB Schenkel, BL Hodous, HL Deak, HN Nguyen, PR Olivieri, ...
Journal of medicinal chemistry 53 (17), 6368-6377, 2010
432010
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants
LB Schenkel, JR Molina, KK Swinger, R Abo, DJ Blackwell, AZ Lu, ...
Cell chemical biology 28 (8), 1158-1168. e13, 2021
412021
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors
EF DiMauro, S Altmann, LM Berry, H Bregman, N Chakka, M Chu-Moyer, ...
Journal of medicinal chemistry 59 (17), 7818-7839, 2016
402016
Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory-and neuropathic-induced mechanical hypersensitivity in rats
SG Lehto, AD Weyer, BD Youngblood, M Zhang, R Yin, W Wang, ...
Molecular pain 12, 1744806916677761, 2016
382016
Synthesis of 4-substituted chlorophthalazines, dihydrobenzoazepinediones, 2-pyrazolylbenzoic acid, and 2-pyrazolylbenzohydrazide via 3-substituted 3-hydroxyisoindolin-1-ones
HN Nguyen, VJ Cee, HL Deak, B Du, KP Faber, H Gunaydin, BL Hodous, ...
The Journal of organic chemistry 77 (8), 3887-3906, 2012
312012
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR
EA Peterson, PS Andrews, X Be, AA Boezio, TL Bush, AC Cheng, ...
Bioorganic & medicinal chemistry letters 21 (7), 2064-2070, 2011
312011
Development of novel azabenzofuran TRPA1 antagonists as in vivo tools
KW Copeland, AA Boezio, E Cheung, J Lee, P Olivieri, LB Schenkel, ...
Bioorganic & Medicinal Chemistry Letters 24 (15), 3464-3468, 2014
262014
Benzothiazole PI3 kinase modulators for cancer treatment
S Booker, N D'angelo, DC D'amico, TS Kim, L Liu, K Meagher, ...
US Patent 7,928,140, 2011
232011
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