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Cristian Nogales
Cristian Nogales
Postdoctoral Researcher. Department of Pharmacology & Personalised Medicine. Maastricht University.
Dirección de correo verificada de maastrichtuniversity.nl
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Network pharmacology: curing causal mechanisms instead of treating symptoms
C Nogales, ZM Mamdouh, M List, C Kiel, AI Casas, HHHW Schmidt
Trends in Pharmacological Sciences 43 (2), 136-150, 2022
3552022
On the clinical pharmacology of reactive oxygen species
AI Casas, C Nogales, HAM Mucke, A Petraina, A Cuadrado, AI Rojo, ...
Pharmacological reviews 72 (4), 801-828, 2020
862020
Network medicine for disease module identification and drug repurposing with the NeDRex platform
S Sadegh, J Skelton, E Anastasi, J Bernett, DB Blumenthal, G Galindez, ...
Nature Communications 12 (1), 6848, 2021
532021
NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype
MH Elbatreek, S Sadegh, E Anastasi, E Guney, C Nogales, T Kacprowski, ...
PLoS biology 18 (11), e3000885, 2020
332020
Cyclic GMP modulating drugs in cardiovascular diseases: Mechanism-based network pharmacology
A Petraina, C Nogales, T Krahn, H Mucke, TF Lüscher, R Fischmeister, ...
Cardiovascular research 118 (9), 2085-2102, 2022
252022
Cancer driver drug interaction explorer
M Hartung, E Anastasi, ZM Mamdouh, C Nogales, HHHW Schmidt, ...
Nucleic acids research 50 (W1), W138-W144, 2022
102022
Network medicine-based unbiased disease modules for drug and diagnostic target identification in ROSopathies
C Nogales, AGB Grønning, S Sadegh, J Baumbach, HHHW Schmidt
Reactive Oxygen Species: Network Pharmacology and Therapeutic Applications …, 2021
92021
Nitrative signaling into cardiac lactate dehydrogenase Trp324 modulates active site loop mobility and activity under metabolic stress
C Nogales, J Frijhoff, D Thoenges, RB Sessions, A Sickmann, ...
bioRxiv, 348789, 2019
3*2019
NeDRex-an integrative and interactive network medicine platform for drug repurposing
S Sadegh, J Skelton, E Anastasi, DB Blumenthal, A Maier, G Galindez, ...
RExPO22 Conference, 2022
12022
Network pharmacology drug repurposing strategy for neurovascular diseases
AI Casas, C Nogales, MH Elbatreek, S Sadegh, E Anastasi, J Skelton, ...
RExPO22 Conference, 2022
12022
Mechanistic endotyping of the ROS/cGMP disease cluster in the Estonian Biobank
C Nogales Calvo, J Kronberg, A Petraina, MP Pachado, M Nelis, L Milani, ...
RExPO22 Conference, 2023
2023
Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes
M Pacheco Pachado, AI Casas, MH Elbatreek, C Nogales, E Guney, ...
Journal of Alzheimer's Disease, 1-10, 2023
2023
Why the way we define diseases prevents innovation and precision medicine
ZM Mamdouh, E Anastasi, AA Hassan, J Boltze, MH Elbatreek, C Nogales, ...
DrugRxiv, 2023
2023
From phenotype to endotype: preclinical validation of ROS-cGMPopathies in the Estonian Biobank
C Nogales, J Kronberg, A Petraina, MP Pachado, J Weerts, AB Aizpurua, ...
JOURNAL OF TRANSLATIONAL MEDICINE 21 (SUPPL 1), 2023
2023
CADDIE-An online knowledge base for network-based mechanism exploration and drug repurposing in oncolog
M Hartung, E Anastasi, Z M Mamdouh, C Nogales, H HHW Schmidt, ...
4th Belgrade Bioinformatics Conference 4, 36-36, 2023
2023
Network pharmacology and drug repurposing pave the way for precision oncology
ZM Mamdouh, C Nogales, C Macchiusi, MH Elbatreek, ...
ScienceOpen, 2022
2022
Repurposing soluble guanylate cyclase stimulators from one to another isoform within the ROCG signalling module
A Petraina, MH Elbatreek, C Elgert, AI Casas, CT Neullens, T Saridaki, ...
ScienceOpen, 2022
2022
An organ-agnostic drug repurposing strategy for dementia: Pre-clinical validation of network pharmacology to treat cerebrovascular dysfunction and cognitive impairment
M Pacheco Pachado, A Petraina, C Nogales, T Saridaki, HHHW Schmidt, ...
ScienceOpen, 2022
2022
Network modules as molecular disease definitions for mechanism-based endotyping anddrug repurposing
C Nogales Calvo, AI Casas, A Petraina, M Pacheco Pachado, S Sadegh, ...
RExPO22, 2022
2022
Network modules as novel molecular disease definitions for precision theranostics
CN Calvo
2021
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