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Seung P Kwak
Seung P Kwak
CHDI Foundation Inc.
Dirección de correo verificada de chdifoundation.org
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Identification of genetic factors that modify clinical onset of Huntington’s disease
JM Lee, VC Wheeler, MJ Chao, JPG Vonsattel, RM Pinto, D Lucente, ...
Cell 162 (3), 516-526, 2015
4062015
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
Y Kim, JY Sung, I Ceglia, KW Lee, JH Ahn, JM Halford, AM Kim, SP Kwak, ...
Nature 442 (7104), 814-817, 2006
3802006
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
P Langfelder, JP Cantle, D Chatzopoulou, N Wang, F Gao, I Al-Ramahi, ...
Nature neuroscience 19 (4), 623-633, 2016
3632016
Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression
DT Chalmers, SP Kwak, A Mansour, H Akil, SJ Watson
Journal of Neuroscience 13 (3), 914-923, 1993
3181993
CAG repeat not polyglutamine length determines timing of Huntington’s disease onset
JM Lee, K Correia, J Loupe, KH Kim, D Barker, EP Hong, MJ Chao, ...
Cell 178 (4), 887-900. e14, 2019
2652019
Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
S Horvath, P Langfelder, S Kwak, J Aaronson, J Rosinski, TF Vogt, ...
Aging (Albany NY) 8 (7), 1485, 2016
2192016
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease
JP Miller, J Holcomb, I Al-Ramahi, M De Haro, J Gafni, N Zhang, E Kim, ...
Neuron 67 (2), 199-212, 2010
2072010
Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene.
SP Kwak, DJ Hakes, KJ Martell, JE Dixon
Journal of Biological Chemistry 269 (5), 3596-3604, 1994
1971994
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease
B Zeitler, S Froelich, K Marlen, DA Shivak, Q Yu, D Li, JR Pearl, JC Miller, ...
Nature medicine 25 (7), 1131-1142, 2019
1622019
Multiple Dual Specificity Protein Tyrosine Phosphatases Are Expressed and Regulated Differentially in Liver Cell Lines (∗)
SP Kwak, JE Dixon
Journal of Biological Chemistry 270 (3), 1156-1160, 1995
1521995
The HTT CAG-expansion mutation determines age at death but not disease duration in Huntington disease
JW Keum, A Shin, T Gillis, JS Mysore, KA Elneel, D Lucente, T Hadzi, ...
The American Journal of Human Genetics 98 (2), 287-298, 2016
1462016
hVH‐5: A protein tyrosine phosphatase abundant in brain that inactivates mitogen‐activated protein kinase
KJ Martell, AF Seasholtz, SP Kwak, KK Clemens, JE Dixon
Journal of neurochemistry 65 (4), 1823-1833, 1995
1371995
A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes
M Ciosi, A Maxwell, SA Cumming, DJH Moss, AM Alshammari, MD Flower, ...
EBioMedicine 48, 568-580, 2019
1302019
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease
XH Lu, VB Mattis, N Wang, I Al-Ramahi, N van den Berg, SA Fratantoni, ...
Science translational medicine 6 (268), 268ra178-268ra178, 2014
1282014
Characterization of the WAVE1 knock-out mouse: implications for CNS development
JP Dahl, J Wang-Dunlop, C Gonzales, MEP Goad, RJ Mark, SP Kwak
Journal of Neuroscience 23 (8), 3343-3352, 2003
1282003
Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis
ELF Holzbaur, DS Howland, N Weber, K Wallace, Y She, S Kwak, ...
Neurobiology of disease 23 (3), 697-707, 2006
1272006
5'-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus
SP Kwak, PD Patel, RC Thompson, H Akil, SJ Watson
Endocrinology 133 (5), 2344-2350, 1993
1241993
WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination
HJ Kim, AB DiBernardo, JA Sloane, MN Rasband, D Solomon, B Kosaras, ...
Journal of Neuroscience 26 (21), 5849-5859, 2006
1152006
A novel receptor-type protein tyrosine phosphatase is expressed during neurogenesis in the olfactory neuroepithelium
KM Walton, KJ Martell, SP Kwak, JE Dixon, BL Largent
Neuron 11 (2), 387-400, 1993
981993
A modifier of Huntington's disease onset at the MLH1 locus
JM Lee, MJ Chao, D Harold, K Abu Elneel, T Gillis, P Holmans, L Jones, ...
Human molecular genetics 26 (19), 3859-3867, 2017
962017
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