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Thomas Hart
Thomas Hart
Postdoctoral Research Fellow, Yale University School of Medicine
Dirección de correo verificada de yale.edu
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Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission
T Hart, NTT Nguyen, NA Nowak, F Zhang, RJ Linhardt, M Diuk-Wasser, ...
PLoS pathogens 14 (5), e1007106, 2018
552018
Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae
DM Tufts, TM Hart, GF Chen, SO Kolokotronis, MA Diuk‐Wasser, YP Lin
Molecular microbiology 111 (4), 868-882, 2019
332019
Immunogenicity of the Lyme disease antigen OspA, particleized by cobalt porphyrin-phospholipid liposomes
J Federizon, A Frye, WC Huang, TM Hart, X He, C Beltran, ...
Vaccine 38 (4), 942-950, 2020
272020
Identification of Lyme borreliae proteins promoting vertebrate host blood-specific spirochete survival in Ixodes scapularis nymphs using artificial feeding chambers
T Hart, X Yang, U Pal, YP Lin
Ticks and tick-borne diseases 9 (5), 1057-1063, 2018
202018
Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system
TM Hart, AP Dupuis, DM Tufts, AM Blom, SR Starkey, ROM Rego, S Ram, ...
PLoS pathogens 17 (7), e1009801, 2021
192021
The factor H-binding site of CspZ as a protective target against multistrain, tick-transmitted Lyme disease
AL Marcinkiewicz, I Lieknina, X Yang, PL Lederman, TM Hart, J Yates, ...
Infection and immunity 88 (5), 10.1128/iai. 00956-19, 2020
162020
Non-anticoagulant heparin as a pre-exposure prophylaxis prevents lyme disease infection
YP Lin, Y Yu, AL Marcinkiewicz, P Lederman, TM Hart, F Zhang, ...
ACS infectious diseases 6 (3), 503-514, 2020
142020
Development of an mRNA-lipid nanoparticle vaccine against Lyme disease
M Pine, G Arora, TM Hart, E Bettini, BT Gaudette, H Muramatsu, ...
Molecular Therapy 31 (9), 2702-2714, 2023
132023
A novel laminin-binding protein mediates microbial-endothelial cell interactions and facilitates dissemination of Lyme disease pathogens
S Bista, P Singh, Q Bernard, X Yang, T Hart, YP Lin, C Kitsou, ...
The Journal of infectious diseases 221 (9), 1438-1447, 2020
102020
A soft tick Ornithodoros moubata salivary protein OmCI is a potent inhibitor to prevent avian complement activation
AM Frye, TM Hart, DM Tufts, S Ram, MA Diuk-Wasser, P Kraiczy, AM Blom, ...
Ticks and tick-borne diseases 11 (2), 101354, 2020
102020
Resistance to Arrenurus spp. Parasitism in Odonates: Patterns Across Species and Comparisons Between a Resistant and Susceptible Host
WB Worthen, TM Hart
Journal of Insect Science 16 (1), 37, 2016
72016
Use of host lipids by the Lyme disease spirochete may lead to biomarkers
G Arora, T Hart, E Fikrig
The Journal of Clinical Investigation 132 (6), 2022
62022
A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ
X Tang, G Arora, J Matias, T Hart, Y Cui, E Fikrig
Cell reports 41 (8), 2022
52022
Structural evolution of an immune evasion determinant shapes pathogen host tropism
AL Marcinkiewicz, K Brangulis, AP Dupuis, TM Hart, M Zamba‐Campero, ...
Proceedings of the National Academy of Sciences 120 (27), e2301549120, 2023
22023
9 Structural evolution of a complement evasion determinant shapes Lyme borreliae host tropism
A Marcinkiewicz, K Brangulis, A DupuisII, T Hart, M Zamba-Campero, ...
Immunobiology 228 (5), 152468, 2023
2023
Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism
AL Marcinkiewicz, K Brangulis, AP Dupuis, TM Hart, M Zamba-Campero, ...
bioRxiv, 2022.09. 13.507797, 2022
2022
Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system [preprint]
TM Hart, II Dupuis, P Alan, DM Tufts, AM Blom, S Starkey, ROM Rego, ...
2021
Molecular Mechanisms Shaping Host Range of a Vector-Borne Pathogen
TM Hart
State University of New York at Albany, 2021
2021
Polymorphic factor H-binding activity of CspA protects Lyme disease borreliae from the host complement
T Hart, NTT Nguyen, N Nowak, F Zhang, RJ Linhardt, M Diuk-Wasser, ...
Rensselaer Polytechnic Institute, Troy, NY, 2018
2018
The effect of water mite parasitism on fluctuating asymmetry and immune response of two dragonfly host species, Argia fumipennis and Pachydiplax longipennis.
T Hart
2015
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Artículos 1–20