RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism J Li, I Sarosi, XQ Yan, S Morony, C Capparelli, HL Tan, S McCabe, ... Proceedings of the national academy of sciences 97 (4), 1566-1571, 2000 | 1442 | 2000 |
Receptor activator of nuclear factor κB ligand and osteoprotegerin regulation of bone remodeling in health and disease AE Kearns, S Khosla, PJ Kostenuik Endocrine reviews 29 (2), 155-192, 2008 | 1150 | 2008 |
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength X Li, MS Ominsky, QT Niu, N Sun, B Daugherty, D D'Agostin, C Kurahara, ... Journal of Bone and Mineral Research 23 (6), 860-869, 2008 | 1128 | 2008 |
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis X Li, MS Ominsky, KS Warmington, S Morony, J Gong, J Cao, Y Gao, ... Journal of Bone and Mineral Research 24 (4), 578-588, 2009 | 966 | 2009 |
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis H Min, S Morony, I Sarosi, CR Dunstan, C Capparelli, S Scully, G Van, ... The Journal of experimental medicine 192 (4), 463-474, 2000 | 809 | 2000 |
Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab DL Lacey, WJ Boyle, WS Simonet, PJ Kostenuik, WC Dougall, JK Sullivan, ... Nature reviews Drug discovery 11 (5), 401-419, 2012 | 780 | 2012 |
Growth factor regulation of fracture repair GL Barnes, PJ Kostenuik, LC Gerstenfeld, TA Einhorn Journal of bone and mineral research 14 (11), 1805-1815, 1999 | 730 | 1999 |
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia J Li, I Sarosi, RC Cattley, J Pretorius, F Asuncion, M Grisanti, S Morony, ... Bone 39 (4), 754-766, 2006 | 563 | 2006 |
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock‐in mice that express chimeric (murine/human) RANKL PJ Kostenuik, HQ Nguyen, J McCabe, KS Warmington, C Kurahara, ... Journal of bone and mineral research 24 (2), 182-195, 2009 | 522 | 2009 |
Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength PJ Kostenuik Current opinion in pharmacology 5 (6), 618-625, 2005 | 450 | 2005 |
Osteoprotegerin A Physiological and Pharmacological Inhibitor of Bone Resorption. PJ Kostenuik Current pharmaceutical design 7 (8), 613-635, 2001 | 382 | 2001 |
Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis S Morony, C Capparelli, I Sarosi, DL Lacey, CR Dunstan, PJ Kostenuik Cancer research 61 (11), 4432-4436, 2001 | 361 | 2001 |
Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in ldlr(−/−) Mice S Morony, Y Tintut, Z Zhang, RC Cattley, G Van, D Dwyer, M Stolina, ... Circulation 117 (3), 411-420, 2008 | 355 | 2008 |
Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats X Li, KS Warmington, QT Niu, FJ Asuncion, M Barrero, M Grisanti, ... Journal of Bone and Mineral Research 25 (12), 2647-2656, 2010 | 291 | 2010 |
Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing LC Gerstenfeld, DJ Sacks, M Pelis, ZD Mason, DT Graves, M Barrero, ... Journal of bone and mineral research 24 (2), 196-208, 2009 | 284 | 2009 |
Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women MT Drake, B Srinivasan, UI Mödder, JM Peterson, LK McCready, ... The Journal of Clinical Endocrinology & Metabolism 95 (11), 5056-5062, 2010 | 272 | 2010 |
Effects of spaceflight on murine skeletal muscle gene expression DL Allen, ER Bandstra, BC Harrison, S Thorng, LS Stodieck, PJ Kostenuik, ... Journal of Applied Physiology 106 (2), 582-595, 2009 | 262 | 2009 |
RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis Q Jin, JA Cirelli, CH Park, JV Sugai, M Taba Jr, PJ Kostenuik, ... Journal of periodontology 78 (7), 1300-1308, 2007 | 253 | 2007 |
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis JR Canon, M Roudier, R Bryant, S Morony, M Stolina, PJ Kostenuik, ... Clinical & experimental metastasis 25, 119-129, 2008 | 246 | 2008 |
Estrogen regulates bone turnover by targeting RANKL expression in bone lining cells C Streicher, A Heyny, O Andrukhova, B Haigl, S Slavic, C Schüler, ... Scientific reports 7 (1), 1-14, 2017 | 239 | 2017 |