James M McFarland
James M McFarland
Broad Institute
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Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ...
Nature genetics 49 (12), 1779-1784, 2017
Patient-derived xenografts undergo mouse-specific tumor evolution
U Ben-David, G Ha, YY Tseng, NF Greenwald, C Oh, J Shih, ...
Nature genetics 49 (11), 1567-1575, 2017
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
SM Corsello, RT Nagari, RD Spangler, J Rossen, M Kocak, JG Bryan, ...
Nature cancer 1 (2), 235-248, 2020
Mutational processes shape the landscape of TP53 mutations in human cancer
AO Giacomelli, X Yang, RE Lintner, JM McFarland, M Duby, J Kim, ...
Nature genetics 50 (10), 1381-1387, 2018
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ...
Nature communications 9 (1), 4610, 2018
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ...
Nature 568 (7753), 551-556, 2019
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
GS Kinker, AC Greenwald, R Tal, Z Orlova, MS Cuoco, JM McFarland, ...
Nature genetics 52 (11), 1208-1218, 2020
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
S Raghavan, PS Winter, AW Navia, HL Williams, A DenAdel, KE Lowder, ...
Cell 184 (25), 6119-6137. e26, 2021
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
GS Wong, J Zhou, JB Liu, Z Wu, X Xu, T Li, D Xu, SE Schumacher, ...
Nature medicine 24 (7), 968-977, 2018
Integrated cross-study datasets of genetic dependencies in cancer
C Pacini, JM Dempster, I Boyle, E Gonçalves, H Najgebauer, E Karakoc, ...
Nature communications 12 (1), 1661, 2021
Inferring nonlinear neuronal computation based on physiologically plausible inputs
JM McFarland, Y Cui, DA Butts
PLoS computational biology 9 (7), e1003143, 2013
Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects
JM Dempster, I Boyle, F Vazquez, DE Root, JS Boehm, WC Hahn, ...
Genome biology 22, 1-23, 2021
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
Y Cohen-Sharir, JM McFarland, M Abdusamad, C Marquis, SV Bernhard, ...
Nature 590 (7846), 486-491, 2021
Spontaneous persistent activity in entorhinal cortex modulates cortico-hippocampal interaction in vivo
TTG Hahn, JM McFarland, S Berberich, B Sakmann, MR Mehta
Nature neuroscience 15 (11), 1531-1538, 2012
Speed controls the amplitude and timing of the hippocampal gamma rhythm
Z Chen, E Resnik, JM McFarland, B Sakmann, MR Mehta
PloS one 6 (6), e21408, 2011
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
JM McFarland, BR Paolella, A Warren, K Geiger-Schuller, T Shibue, ...
Nature communications 11 (1), 4296, 2020
A first-generation pediatric cancer dependency map
NV Dharia, G Kugener, LM Guenther, CF Malone, AD Durbin, AL Hong, ...
Nature genetics 53 (4), 529-538, 2021
Global computational alignment of tumor and cell line transcriptional profiles
A Warren, Y Chen, A Jones, T Shibue, WC Hahn, JS Boehm, F Vazquez, ...
Nature communications 12 (1), 22, 2021
Saccadic modulation of stimulus processing in primary visual cortex
JM McFarland, AG Bondy, RC Saunders, BG Cumming, DA Butts
Nature communications 6 (1), 8110, 2015
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Artículos 1–20