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Ulrich M Zanger
Ulrich M Zanger
Professor of Biochemical Pharmacology, Dr. Margarete Fischer-Bosch-Institute of Clinical
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Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
UM Zanger, M Schwab
Pharmacology & therapeutics 138 (1), 103-141, 2013
39372013
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry
UM Zanger, S Raimundo, M Eichelbaum
Naunyn-Schmiedeberg's archives of pharmacology 369, 23-37, 2004
11062004
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
FJ Gonzalez, RC Skodat, S Kimura, M Umeno, UM Zanger, DW Nebert, ...
Nature 331 (6155), 442-446, 1988
9061988
The genetic determinants of the CYP3A5 polymorphism
E Hustert, M Haberl, O Burk, R Wolbold, YQ He, K Klein, AC Nuessler, ...
Pharmacogenetics and Genomics 11 (9), 773-779, 2001
8272001
Molecular mechanisms of genetic polymorphisms of drug metabolism
UA Meyer, UM Zanger
Annual review of pharmacology and toxicology 37 (1), 269-296, 1997
7531997
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
UM Zanger, M Turpeinen, K Klein, M Schwab
Analytical and bioanalytical chemistry 392, 1093-1108, 2008
7302008
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
T Lang, K Klein, J Fischer, AK Nüssler, P Neuhaus, U Hofmann, ...
Pharmacogenetics and Genomics 11 (5), 399-415, 2001
7042001
Sex is a major determinant of CYP3A4 expression in human liver
R Wolbold, K Klein, O Burk, AK Nüssler, P Neuhaus, M Eichelbaum, ...
Hepatology 38 (4), 978-988, 2003
6082003
Nomenclature for human CYP2D6 alleles
AK Daly, J Brockmoller, F Broly, M Eichelbaum, WE Evans, FJ Gonzalez, ...
Pharmacogenetics and Genomics 6 (3), 193-201, 1996
6011996
Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
W Schroth, L Antoniadou, P Fritz, M Schwab, T Muerdter, UM Zanger, ...
Journal of Clinical Oncology 25 (33), 5187-5193, 2007
5902007
Comprehensive analysis of thiopurine S-methyltransferase phenotype–genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
E Schaeffeler, C Fischer, D Brockmeier, D Wernet, K Moerike, ...
Pharmacogenetics and Genomics 14 (7), 407-417, 2004
5222004
Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group
M Schwab, UM Zanger, C Marx, E Schaeffeler, K Klein, J Dippon, R Kerb, ...
Journal of clinical oncology 26 (13), 2131-2138, 2008
4662008
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
AT Nies, H Koepsell, S Winter, O Burk, K Klein, R Kerb, UM Zanger, ...
Hepatology 50 (4), 1227-1240, 2009
4372009
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
M Schwab, E Schaeffeler, C Marx, MF Fromm, B Kaskas, J Metzler, ...
Gastroenterology 124 (1), 26-33, 2003
4312003
Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA
I Koch, R Weil, R Wolbold, J Brockmöller, E Hustert, O Burk, A Nuessler, ...
Drug Metabolism and Disposition 30 (10), 1108-1114, 2002
4142002
Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
EU Griese, UM Zanger, U Brudermanns, A Gaedigk, G Mikus, K Mörike, ...
Pharmacogenetics and Genomics 8 (1), 15-26, 1998
4141998
Frequency of C3435T polymorphism of MDR1 gene in African people
E Schaeffeler, M Eichelbaum, U Brinkmann, A Penger, S Asante-Poku, ...
The Lancet 358 (9279), 383-384, 2001
3672001
Clinical relevance of DPYD variants c. 1679T> G, c. 1236G> A/HapB3, and c. 1601G> A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta …
D Meulendijks, LM Henricks, GS Sonke, MJ Deenen, TK Froehlich, ...
The Lancet Oncology 16 (16), 1639-1650, 2015
3662015
Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
UM Zanger, J Fischer, S Raimundo, T Stüven, BO Evert, M Schwab, ...
Pharmacogenetics and Genomics 11 (7), 573-585, 2001
3442001
Identification and functional characterization of eight CYP3A4 protein variants
R Eiselt, TL Domanski, A Zibat, R Mueller, E Presecan-Siedel, E Hustert, ...
Pharmacogenetics and Genomics 11 (5), 447-458, 2001
3372001
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