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Mahesh Aitha
Mahesh Aitha
Scientist, NIH
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A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases
MN Lisa, AR Palacios, M Aitha, MM González, DM Moreno, MW Crowder, ...
Nature communications 8 (1), 538, 2017
1262017
Mechanistic and spectroscopic studies of metallo-β-lactamase NDM-1
H Yang, M Aitha, AM Hetrick, TK Richmond, DL Tierney, MW Crowder
Biochemistry 51 (18), 3839-3847, 2012
1222012
Spectroscopic and mechanistic studies of heterodimetallic forms of metallo-β-lactamase NDM-1
H Yang, M Aitha, AR Marts, A Hetrick, B Bennett, MW Crowder, ...
Journal of the American Chemical Society 136 (20), 7273-7285, 2014
812014
Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-​β-​lactamase VIM-​2
M Aitha, AR Marts, A Bergstrom, AJ Moeller, L Moritz, L Turner, JC Nix, ...
Biochemistry 53 (46), 7321-7331, 2014
702014
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7
A Bergstrom, A Katko, Z Adkins, J Hill, Z Cheng, M Burnett, H Yang, ...
ACS infectious diseases 4 (2), 135-145, 2018
572018
Investigating the position of the hairpin loop in New Delhi metallo-β-lactamase, NDM-1, during catalysis and inhibitor binding
M Aitha, AJ Moller, ID Sahu, M Horitani, DL Tierney, MW Crowder
Journal of inorganic biochemistry 156, 35-39, 2016
312016
Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen
M Hedglin, M Aitha, A Pedley, SJ Benkovic
Journal of biological chemistry 294 (13), 5157-5168, 2019
302019
New β-phospholactam as a carbapenem transition state analog: synthesis of a broad-spectrum inhibitor of metallo-β-lactamases
KW Yang, L Feng, SK Yang, M Aitha, AE LaCuran, P Oelschlaeger, ...
Bioorganic & medicinal chemistry letters 23 (21), 5855-5859, 2013
292013
Conformational dynamics of metallo-​β-​lactamase CcrA during catalysis investigated by using DEER spectroscopy
M Aitha, L Moritz, ID Sahu, O Sanyurah, Z Roche, R McCarrick, ...
Journal of Biological Inorganic Chemistry 20, 2015
212015
Metal ion dependence of the matrix metalloproteinase-1 mechanism
H Yang, K Makaroff, N Paz, M Aitha, MW Crowder, DL Tierney
Biochemistry 54 (23), 3631-3639, 2015
162015
Dilution of dipolar interactions in a spin-labeled, multimeric metalloenzyme for DEER studies
M Aitha, TK Richmond, Z Hu, A Hetrick, R Reese, A Gunther, R McCarrick, ...
Journal of inorganic biochemistry 136, 40-46, 2014
162014
Monitoring the retention of human proliferating cell nuclear antigen at primer/template junctions by proteins that bind single-stranded DNA
M Hedglin, M Aitha, SJ Benkovic
Biochemistry 56 (27), 3415-3421, 2017
142017
Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis
P Oelschlaeger, M Aitha, H Yang, JS Kang, AL Zhang, EM Liu, JD Buynak, ...
Antimicrobial Agents and Chemotherapy 59 (7), 4326-4330, 2015
132015
Serum-stable and selective backbone-N-methylated cyclic peptides that inhibit prokaryotic glycolytic mutases
RHP Van Neer, PK Dranchak, L Liu, M Aitha, B Queme, H Kimura, ...
ACS chemical biology 17 (8), 2284-2295, 2022
112022
Reactions of Zn 2, Cd 2 and Hg 2 with Free Adenine
YZ Hamadaa, T Burkeyb, E Waddellc, M Aithad, N Phambud
Journal of Applied Solution Chemistry and Modeling 2, 77-84, 2013
102013
A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-beta-lactamases. Nat Commun 8: 538
MN Lisa, AR Palacios, M Aitha, MM González, DM Moreno, MW Crowder, ...
92017
Probing substrate binding to the metal binding sites in metallo-β-lactamase L1 during catalysis
M Aitha, S Al-Adbul-Wahid, DL Tierney, MW Crowder
MedChemComm 7 (1), 194-201, 2016
82016
Mechanism-based cephalosporin inhibitors of metallo-and serine-carbapenemases
LD Sutton, S Yu, A Yu, M Yu, M Aitha, M Crowder, N Zhou, M Broderick, ...
Interscience Conference on Antimicrobial Agents and Chemotherapy, 2013
62013
HME
A Bergstrom, A Katko, Z Adkins, J Hill, Z Cheng, M Burnett, H Yang, ...
Martin, NI, Bonomo, RA, Page, RC, Tierney, DL, Fast, W., Wright, GD, and …, 2018
42018
Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases
M Wiedmann, PK Dranchak, M Aitha, B Queme, CD Collmus, ...
Journal of Biological Chemistry 296, 2021
22021
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Artículos 1–20