Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer E Ballestar, MF Paz, L Valle, S Wei, MF Fraga, J Espada, JC Cigudosa, ... The EMBO journal 22 (23), 6335-6345, 2003 | 422 | 2003 |
POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance F Bellido, M Pineda, G Aiza, R Valdés-Mas, M Navarro, DA Puente, ... Genetics in Medicine 18 (4), 325-332, 2016 | 268 | 2016 |
New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis L Valle, E Hernández-Illán, F Bellido, G Aiza, A Castillejo, MI Castillejo, ... Human molecular genetics 23 (13), 3506-3512, 2014 | 189 | 2014 |
Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine L Valle, E Vilar, SV Tavtigian, EM Stoffel The Journal of pathology 247 (5), 574-588, 2019 | 187 | 2019 |
Germline Allele-Specific Expression of TGFBR1 Confers an Increased Risk of Colorectal Cancer L Valle, T Serena-Acedo, S Liyanarachchi, H Hampel, I Comeras, Z Li, ... Science 321 (5894), 1361-1365, 2008 | 163 | 2008 |
Mutational signature analysis reveals NTHL1 deficiency to cause a multi-tumor phenotype JE Grolleman, RM De Voer, FA Elsayed, M Nielsen, RDA Weren, C Palles, ... Cancer cell 35 (2), 256-266. e5, 2019 | 161 | 2019 |
Update on genetic predisposition to colorectal cancer and polyposis L Valle, RM de Voer, Y Goldberg, W Sjursen, A Försti, C Ruiz-Ponte, ... Molecular aspects of medicine 69, 10-26, 2019 | 150 | 2019 |
Germline mutations in FAN1 cause hereditary colorectal cancer by impairing DNA repair N Seguí, LB Mina, C Lázaro, R Sanz-Pamplona, T Pons, M Navarro, ... Gastroenterology 149 (3), 563-566, 2015 | 126 | 2015 |
Genetic predisposition to colorectal cancer: where we stand and future perspectives L Valle World journal of gastroenterology: WJG 20 (29), 9828, 2014 | 119 | 2014 |
Role of POLE and POLD1 in familial cancer P Mur, S García-Mulero, J Del Valle, L Magraner-Pardo, A Vidal, ... Genetics in medicine 22 (12), 2089-2100, 2020 | 102 | 2020 |
Recent discoveries in the genetics of familial colorectal cancer and polyposis L Valle Clinical Gastroenterology and Hepatology 15 (6), 809-819, 2017 | 99 | 2017 |
A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation S Alvarez, R Diaz-Uriarte, A Osorio, A Barroso, L Melchor, MF Paz, ... Clinical Cancer Research 11 (3), 1146-1153, 2005 | 93 | 2005 |
Clinicopathologic and pedigree differences in Amsterdam I–positive hereditary nonpolyposis colorectal cancer families according to tumor microsatellite instability status L Valle, J Perea, P Carbonell, V Fernandez, AM Dotor, J Benitez, ... Journal of clinical oncology 25 (7), 781-786, 2007 | 86 | 2007 |
MLH1 germline epimutations in selected patients with early‐onset non‐polyposis colorectal cancer L Valle, P Carbonell, V Fernandez, AM Dotor, M Sanz, J Benitez, ... Clinical genetics 71 (3), 232-237, 2007 | 73 | 2007 |
A novel germline POLE mutation causes an early onset cancer prone syndrome mimicking constitutional mismatch repair deficiency K Wimmer, A Beilken, R Nustede, T Ripperger, B Lamottke, B Ure, ... Familial cancer 16, 67-71, 2017 | 69 | 2017 |
Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development Q Zeng, S Phukan, Y Xu, M Sadim, DS Rosman, M Pennison, J Liao, ... Cancer research 69 (2), 678-686, 2009 | 69 | 2009 |
Evidence suggests that germline RNF43 mutations are a rare cause of serrated polyposis I Quintana, R Mejías-Luque, M Terradas, M Navarro, V Piñol, P Mur, ... Gut 67 (12), 2230-2232, 2018 | 64 | 2018 |
Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer R Sanz-Pamplona, A Lopez-Doriga, L Paré-Brunet, K Lázaro, F Bellido, ... Clinical cancer research 21 (20), 4709-4718, 2015 | 62 | 2015 |
The inherited and familial component of early-onset colorectal cancer M Daca Alvarez, I Quintana, M Terradas, P Mur, F Balaguer, L Valle Cells 10 (3), 710, 2021 | 60 | 2021 |
Lynch syndrome G Idos, L Valle | 60 | 2021 |