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Jeff McKenna
Jeff McKenna
Dirección de correo verificada de novartis.com
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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ...
Nature chemical biology 15 (7), 747-755, 2019
3562019
Magnitude of therapeutic STING activation determines CD8+ T cell-mediated anti-tumor immunity
KE Sivick, AL Desbien, LH Glickman, GL Reiner, L Corrales, NH Surh, ...
Cell reports 25 (11), 3074-3085. e5, 2018
3542018
Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications
CC Ward, JI Kleinman, SM Brittain, PS Lee, CYS Chung, K Kim, Y Petri, ...
ACS chemical biology 14 (11), 2430-2440, 2019
2682019
The most common functional groups in bioactive molecules and how their popularity has evolved over time
P Ertl, E Altmann, JM McKenna
Journal of medicinal chemistry 63 (15), 8408-8418, 2020
2452020
Deubiquitinase-targeting chimeras for targeted protein stabilization
NJ Henning, L Boike, JN Spradlin, CC Ward, G Liu, E Zhang, BP Belcher, ...
Nature chemical biology 18 (4), 412-421, 2022
2012022
Asymmetric palladium-catalyzed directed intermolecular fluoroarylation of styrenes
EPA Talbot, TA Fernandes, JM McKenna, FD Toste
Journal of the American Chemical Society 136 (11), 4101-4104, 2014
1532014
Discovery of a covalent FEM1B recruiter for targeted protein degradation applications
NJ Henning, AG Manford, JN Spradlin, SM Brittain, E Zhang, JM McKenna, ...
Journal of the American Chemical Society 144 (2), 701-708, 2022
1342022
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
IM McLay, F Halley, JE Souness, J McKenna, V Benning, M Birrell, ...
Bioorganic & medicinal chemistry 9 (2), 537-554, 2001
1242001
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
M Luo, JN Spradlin, L Boike, B Tong, SM Brittain, JM McKenna, ...
Cell chemical biology 28 (4), 559-566. e15, 2021
1202021
Bardoxolone conjugation enables targeted protein degradation of BRD4
B Tong, M Luo, Y Xie, JN Spradlin, JA Tallarico, JM McKenna, M Schirle, ...
Scientific reports 10 (1), 15543, 2020
1102020
Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC
L Boike, AG Cioffi, FC Majewski, NJ Henning, MD Jones, G Liu, ...
Cell chemical biology 28 (1), 4-13. e17, 2021
1072021
Manumycin polyketides act as molecular glues between UBR7 and P53
Y Isobe, M Okumura, LM McGregor, SM Brittain, MD Jones, X Liang, ...
Nature chemical biology 16 (11), 1189-1198, 2020
1052020
An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors
JM McKenna, F Halley, JE Souness, IM McLay, SD Pickett, AJ Collis, ...
Journal of medicinal chemistry 45 (11), 2173-2184, 2002
1022002
A nimbolide-based kinase degrader preferentially degrades oncogenic BCR-ABL
B Tong, JN Spradlin, LFT Novaes, E Zhang, X Hu, M Moeller, SM Brittain, ...
ACS chemical biology 15 (7), 1788-1794, 2020
902020
The development and mechanistic investigation of a palladium-catalyzed 1, 3-arylfluorination of chromenes
RT Thornbury, V Saini, TA Fernandes, CB Santiago, EPA Talbot, ...
Chemical Science 8 (4), 2890-2897, 2017
842017
Gold‐Catalyzed Redox Synthesis of Imidazo[1,2‐a]pyridines using Pyridine N‐Oxide and Alkynes
EPA Talbot, M Richardson, JM McKenna, FD Toste
Advanced synthesis & catalysis 356 (4), 687-691, 2014
772014
Rational chemical design of molecular glue degraders
ES Toriki, JW Papatzimas, K Nishikawa, D Dovala, AO Frank, MJ Hesse, ...
ACS central science 9 (5), 915-926, 2023
762023
Studies on the stereoselective synthesis of the marine antitumor agent eleutherobin
R Carter, K Hodgetts, J McKenna, P Magnus, S Wren
Tetrahedron 56 (26), 4367-4382, 2000
752000
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
DS Mortensen, MMD Mederos, JJ Sapienza, RJ Albers, SS Clareen, ...
US Patent 7,968,556, 2011
622011
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
EA King, Y Cho, NS Hsu, D Dovala, JM McKenna, JA Tallarico, M Schirle, ...
Cell chemical biology 30 (4), 394-402. e9, 2023
522023
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Artículos 1–20